spiro[cycloprop-2-ene-1,9'-fluorene] | 1263324-40-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: spiro[cycloprop-2-ene-1,9'-fluorene]
• 英文别名: Spiro[cyclopropene-3,9'-fluorene]
• CAS: 1263324-40-8
• 化学式: C₁₅H₁₀
• 分子量: 190.244
• InChiKey: OZCDHOPHYBDULM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  spiro[cycloprop-2-ene-1,9'-fluorene] 在 双(乙腈)氯化钯(II) 、 zinc trifluoromethanesulfonate 、 臭氧 、 (±)-2,2 '-二(二-对甲苯基膦)-1,1 '-联萘 作用下， 以 二氯甲烷 为溶剂， 反应 5.5h， 生成 ethylspiro[cyclopropane-1,9'-fluoren-3-yl]2-phenylethanol
  参考文献：
  名称：

  Enantioselective Palladium-Catalyzed Carbozincation of Cyclopropenes

  摘要：

  A highly enantioselective palladium-catalyzed carbozincation of cyclopropenes has been developed. The intermediate cyclopropylzinc species, after transmetalation with copper, were trapped with various electrophiles. This one-pot procedure furnished functionalizied cyclopropenes with excellent diastereo- and enantioselectivity.

  DOI：

  10.1021/ol1029904
• 作为产物：
  描述：

  9-重氮基-9H-芴 在 辛酸铑 、 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 生成 spiro[cycloprop-2-ene-1,9'-fluorene]
  参考文献：
  名称：

  Enantioselective Palladium-Catalyzed Carbozincation of Cyclopropenes

  摘要：

  A highly enantioselective palladium-catalyzed carbozincation of cyclopropenes has been developed. The intermediate cyclopropylzinc species, after transmetalation with copper, were trapped with various electrophiles. This one-pot procedure furnished functionalizied cyclopropenes with excellent diastereo- and enantioselectivity.

  DOI：

  10.1021/ol1029904

文献信息

• Assembly of polysubstituted chiral cyclopropylamines <i>via</i> highly enantioselective Cu-catalyzed three-component cyclopropene alkenylamination
  作者：Yu Zhang、Yuan Li、Wei Zhou、Mengru Zhang、Qian Zhang、Ran Jia、Jinbo Zhao

  DOI：10.1039/d0cc01060j

  日期：——

  A Cu-based chiral catalyst enables convergent, highly enantioselective three-component assembly of alkenyl cyclopropylamines containing up to all three stereogenic centers.

  一种基于铜的手性催化剂使得具有最多三个立体中心的烯基环丙胺的三组分汇合反应实现了收敛的高对映选择性。
• Enantioselective Palladium-Catalyzed Carbozincation of Cyclopropenes
  作者：Katja Krämer、Paul Leong、Mark Lautens

  DOI：10.1021/ol1029904

  日期：2011.2.18

  A highly enantioselective palladium-catalyzed carbozincation of cyclopropenes has been developed. The intermediate cyclopropylzinc species, after transmetalation with copper, were trapped with various electrophiles. This one-pot procedure furnished functionalizied cyclopropenes with excellent diastereo- and enantioselectivity.