3,3'-dimethoxy-1,1'-biphenyl-2,2'-diol | 4542-41-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3'-dimethoxy-1,1'-biphenyl-2,2'-diol
• 英文别名: 3,3'-dimethoxy-2,2'-dihydroxy-1,1'-biphenyl；diguaiacol；3,3'-dimethoxy-2,2'-dihydroxybiphenyl；3,3'-Dimethoxy-biphenyl-2,2'-diol；2-(2-Hydroxy-3-methoxyphenyl)-6-methoxyphenol
• CAS: 4542-41-0
• 化学式: C₁₄H₁₄O₄
• 分子量: 246.263
• InChiKey: AFIPBMISVQFZME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,3'-dimethoxy-1,1'-biphenyl-2,2'-diol 在 吡啶 、 benzyltriethylammonium perbromide 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 4,4'-dimethoxy-2-bromo-6-methoxydibenzo-(d,f)(1,3,2)dioxaphosphepin-6-oxide
  参考文献：
  名称：

  6,6′-Dibromo-3,3′-dimethoxy-2,2′-dihydroxy-1,1′-biphenyl: preparation and resolution

  摘要：

  A pratical route to prepare the title biphenyl 1 starting from 3,3',2,2'-tetramethoxy- 1,1'-biphenyl 2 is described. Resolution of 1 was achieved by its conversion into the corresponding diastereomeric menthyl-dicarbonate. The absolute configuration of (P)-(+)-1 was confirmed by X-ray analysis of the related diastereomer, (C) 2000 Elsevier Science Ltd, All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00121-x
• 作为产物：
  描述：

  3-(5-羧基-2-羟基-3-甲氧基苯基)-4-羟基-5-甲氧基苯甲酸 生成 3,3'-dimethoxy-1,1'-biphenyl-2,2'-diol
  参考文献：
  名称：

  198.过氧化物酶作用的研究。第十部分苯酚的氧化

  摘要：

  DOI：

  10.1039/jr9560000940

文献信息

• Ir-Catalyzed Ligand-Free Directed C–H Borylation of Arenes and Pharmaceuticals: Detailed Mechanistic Understanding
  作者：Mirja Md Mahamudul Hassan、Biplab Mondal、Sukriti Singh、Chabush Haldar、Jagriti Chaturvedi、Ranjana Bisht、Raghavan B. Sunoj、Buddhadeb Chattopadhyay

  DOI：10.1021/acs.joc.2c00046

  日期：2022.3.18

  intermediacy of an Ir-boryl complex where the substrate C–H activation is the turnover determining step, intriguingly without any appreciable primary KIE. The method displays a broad range of substrate scope and functional group tolerance. Numerous late-stage borylation of various important molecules and drugs were achieved using this developed strategy. The borylated compounds were further converted into

  一种 Ir 催化的芳烃（例如 2-苯氧基吡啶、2-苯胺基吡啶、苄胺、苄基哌嗪、苄基吗啉、苄基吡咯烷、苄基哌啶、苄基氮杂环己烷、α-氨基酸衍生物、氨基苯基乙烷衍生物和其他重要支架）的无配体邻位硼化的有效方法) 并开发了药物。正如通过使用动力学同位素研究和 DFT 计算进行的详细机理研究所揭示的那样，该反应通过一个有趣的机理途径进行。发现催化循环涉及 Ir-硼基络合物的中间体，其中底物 C-H 活化是转换决定步骤，有趣的是没有任何明显的初级 KIE。该方法显示了广泛的底物范围和官能团耐受性。使用这种开发的策略实现了各种重要分子和药物的许多后期硼化。硼化化合物进一步转化为更有价值的官能团。此外，利用单硼化化合物的 B-N 分子内相互作用的优势，开发了一种操作简单的方法，用于选择性二硼化 2-苯氧基吡啶和许多官能化芳烃。此外，还展示了从硼化产物中去除吡啶基导向基团以实现邻硼化苯酚以及用于制备 1,2-二硼化苯的
• Miscibility and Hydrogen Bonding in Blends of Poly(ethylene oxide) and Kraft Lignin
  作者：John F. Kadla、Satoshi Kubo

  DOI：10.1021/ma0348371

  日期：2003.10.1

  Polymer blending is a convenient method to develop products with desirable properties. Through specific intermolecular interactions favorable polymer blending can occur, and composite materials with desirable properties can be produced. In this study we have prepared poly(ethylene oxide)−lignin blends using thermal mixing. Miscible blends were observed over the entire blend ratio. A melting point depression

  聚合物共混是开发具有所需性能的产品的便捷方法。通过特定的分子间相互作用，可以发生良好的聚合物共混，并且可以生产具有所需性能的复合材料。在这项研究中，我们使用热混合制备了聚环氧乙烷-木质素共混物。在整个混合比中观察到可混溶的混合。观察到熔点降低，与苯氧基/ PEO共混物获得的结果相当，并且T g与重均值呈负偏差。分析了二元相互作用参数χ对T g的影响。T g的令人满意的预测获得组成曲线，其中存在特定的分子间相互作用。FT-IR分析表明，PEO中的芳族羟基质子与醚氧之间具有很强的氢键。
• Conversion of lignin into bioplastics and lipid fuels
  申请人：The Texas A&M University System

  公开号：US11519011B2

  公开（公告）日：2022-12-06

  The present invention provides methods and compositions for increasing lignin degradation to produce a biological product. Also provided are methods for increasing expression of laccase in a bacterial species to produce increased lignin degradation. Also provided are bacterial cells and commodities or commodity produces produced from such methods.

  本发明提供了增加木质素降解以生产生物产品的方法和组合物。本发明还提供了在细菌物种中增加漆酶表达以提高木质素降解的方法。本发明还提供了细菌细胞和用这种方法生产的商品或商品产品。
• Chiral nonracemic C2-symmetry biphenyls by desymmetrization of 6,6′,2,2′-tetramethoxy-1,1′-biphenyl
  作者：Giovanna Delogu、Davide Fabbri、Maria Antonietta Dettori、Alessandra Forni、Gianluigi Casalone

  DOI：10.1016/s0957-4166(00)00410-9

  日期：2000.11

  Regioselective bromination of the title biphenyl 1 at the 3 and 3' positions and simultaneous desymmetrization of the biphenyl has been achieved. Metal-halide exchange at the 3,3' positions facilitated the introduction of functional groups in good yield. Regioselective reduction was obtained by using (CH3)(3)SiI, L-Selectride and HI according to the functional groups on the biphenyls. Resolution of 6,6',2,2'-tetramethoxy-3,3'-dimethyl-1,1'-biphenyl 3 was achieved by its conversion to the corresponding phosphorothioamidate diastereomers of the (S)-(-)-alpha -methylbenzylamine. The absolute configuration of (M)-(+)-3 was confirmed by X-ray analysis of the corresponding diastereomer. (C) 2000 Elsevier Science Ltd. All rights reserved.
• US6025503A
  申请人：——

  公开号：US6025503A

  公开（公告）日：2000-02-15