5α.14β-androstane-carboxylic acid-(17α)-methyl ester | 15173-52-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5α.14β-androstane-carboxylic acid-(17α)-methyl ester
• 英文别名: 5α.14β-Androstan-carbonsaeure-(17α)-methylester；methyl (5R,8R,9S,10S,13S,14R,17R)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylate
• CAS: 15173-52-1；15173-92-9；88929-08-2；89194-95-6；102571-82-4
• 化学式: C₂₁H₃₄O₂
• 分子量: 318.5
• InChiKey: UYRKOPHGLDACOQ-YNGMDASDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  methyl 3β-acetoxy-5α-androst-16-ene-17-carboxylate 在 盐酸 、 四氯化碳 、 N-溴代丁二酰亚胺(NBS) 、 乙醇 、 二氧化碳 、 溶剂黄146 、 铂 作用下， 生成 5α.14β-androstane-carboxylic acid-(17α)-methyl ester
  参考文献：
  名称：

  Tissue and Blood Levels of Zinc, Copper, and Magnesium in Nitric Oxide Synthase Blockade-Induced Hypertension

  摘要：

  The aim of this study was to determine the levels of tissue and blood zinc (Zn), copper (Cu), magnesium (Mg) in nitric oxide (NO) synthase blockade-induced hypertension. A group of albino rats received a NO synthase inhibitor, N-G-nitro-L-arginine-methyl ester (L-NAME, 60 mg/kg/d) in their drinking water for 21 d. L-NAME intake caused a progressive rise in this group's resting mean arterial blood pressure compared to a control group (p < 0.01). There were no differences between the groups with regard to tissue and blood levels of Zn or Cu; however, Mg concentrations were significantly lower in the hypertensive rats' erythrocytes (20.2% reduction from control levels), cerebral cortex (17.0%), heart (9.1%), renal cortex (12%), renal medulla (16.7%), and in the tissues of the caval vein (23.7%), mesenteric artery (29.8%), renal artery (18.4%), and renal vein (22.1%). There were no significant Mg concentration changes in the hypertensive group's plasma, cerebellum, liver, duodenum, or aortal tissue. These findings suggest that Mg depletion may play a role in the blood pressure rise that occurs in the model of chronic NO synthase inhibition-induced hypertension.

  DOI：

  10.1385/bter:77:2:97

文献信息

• Konfiguration des Periplogenins und desallo-Periplogenins
  作者：P. Speiser、T. Reichstein

  DOI：10.1002/hlca.19470300732

  日期：1947.12.1