1-溴-4,8-二甲氧基萘 | 125366-89-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1-溴-4,8-二甲氧基萘
• 英文名称: 1-bromo-4,8-dimethoxynaphthalene
• 英文别名: 4-Bromo-1,5-dimethoxynaphthalene；4-bromo-1,5-dimethoxy-naphthalene；4-Brom-1,5-dimethoxy-naphthalin
• CAS: 125366-89-4
• 化学式: C₁₂H₁₁BrO₂
• 分子量: 267.122
• InChiKey: WETIXPBBCSDHOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-溴-4,8-二甲氧基萘 在 N-溴代丁二酰亚胺(NBS) 、 hydrazine hydrate 、 锌 、 三氯氧磷 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 生成 (1,4,5,8-tetramethoxy-2-naphthyl)methanol
  参考文献：
  名称：

  An efficient reduction of nitro and bromine naphthalene derivatives

  摘要：

  Reduction of 1,5-dimethoxy-4-nitronaphthalene by hydrazine hydrate was optimized in the course of current study. Influence of metals, temperature and solvents upon the process was tested. Yield of the reaction was the highest in the presence of Zn powder in DMF. Moderate heating made the process slightly more efficient than that at room temperature, whereas high temperature led to a decreased yield. The current approach made it possible to exclude high pressure and diminish experimental costs.

  DOI：

  10.1134/s1070363217040272
• 作为产物：
  描述：

  1,5-二羟基萘 在 N-溴代丁二酰亚胺(NBS) 、 sodium hydroxide 作用下， 以 四氢呋喃 、 水 、 乙腈 为溶剂， 反应 2.0h， 生成 1-溴-4,8-二甲氧基萘
  参考文献：
  名称：

  An efficient reduction of nitro and bromine naphthalene derivatives

  摘要：

  Reduction of 1,5-dimethoxy-4-nitronaphthalene by hydrazine hydrate was optimized in the course of current study. Influence of metals, temperature and solvents upon the process was tested. Yield of the reaction was the highest in the presence of Zn powder in DMF. Moderate heating made the process slightly more efficient than that at room temperature, whereas high temperature led to a decreased yield. The current approach made it possible to exclude high pressure and diminish experimental costs.

  DOI：

  10.1134/s1070363217040272

文献信息

• A Synthetic Route of 1,4,8-Trimethoxy-2-naphthalenecarbaldehyde via Duff Formylation of 4,8-Dimethoxy-1-naphthol
  作者：Yasuhiro Tanoue、Akira Terada、Yasuyuki Matsumoto

  DOI：10.1246/bcsj.62.2736

  日期：1989.8

  A convenient route for preparing 1,4,8-trimethoxy-2-naphthalenecarbaldehyde was accomplished by the following: The starting material, 4,8-dimethoxy-1-naphthol, was prepared from 1,5-dimethoxynaphthalene through 1-bromo-4,8-dimethoxynaphthalene. Formylation of this naphthol and subsequent methylation gave 1,4,8-trimethoxy-2-naphthalenecarbaldehyde.

  一种方便制备1,4,8-三甲氧基-2-萘甲醛的途径如下：起始原料4,8-二甲氧基-1-萘醇是通过1,5-二甲氧基萘经过1-溴-4,8-二甲氧基萘制备的。对该萘醇进行甲酰化反应后，再进行甲基化反应，最终得到1,4,8-三甲氧基-2-萘甲醛。
• 화합물 및 이를 포함한 유기 발광 소자
  申请人：Samsung Display Co., Ltd. 삼성디스플레이 주식회사(120120164552) Corp. No ▼ 134511-0187812

  公开号：KR20150104678A

  公开（公告）日：2015-09-16

  하기 화학식 1로 표현되는 화합물 및 이를 포함하는 유기 발광 소자가 개시된다: <화학식 1> 상기 화학식 1에 대한 설명은 발명의 상세한 설명을 참고한다.

  本发明公开了下式 1 所代表的化合物以及包含这些化合物的有机发光器件：<方案 1>关于式 1 的说明，请参阅本发明的详细说明。
• Fischer,O.; Bauer, Journal fur praktische Chemie (Leipzig 1954), 1916, vol. <2> 94, p. 22
  作者：Fischer,O.、Bauer

  DOI：——

  日期：——
• N-Bromosuccinimide in Acetonitrile: A Mild and Regiospecific Nuclear Brominating Reagent for Methoxybenzenes and Naphthalenes
  作者：M. Carmen Carreno、Jose L. Garcia Ruano、Gema Sanz、Miguel A. Toledo、Antonio Urbano

  DOI：10.1021/jo00121a064

  日期：1995.8
• 70. The nitration of 1 : 5-dihydroxy- and 1 : 5-diacetoxy-naphthalene, 1-acetoxy-5-methoxynaphthalene, 5-methoxy-1-naphthol, and 1 : 5-di-methoxynaphthalene
  作者：R. H. Thomson、E. Race、F. M. Rowe

  DOI：10.1039/jr9470000350

  日期：——