Propyl 2-amino-4-fluorobenzoate | 1038342-88-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Propyl 2-amino-4-fluorobenzoate
• CAS: 1038342-88-9
• 化学式: C₁₀H₁₂FNO₂
• 分子量: 197.209
• InChiKey: MDBNXOHRZHQXLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Propyl 2-amino-4-fluorobenzoate 、 邻氟苯甲酰氯 以 二氯甲烷 为溶剂， 反应 16.0h， 以69%的产率得到Propyl 4-fluoro-2-[(2-fluorobenzoyl)amino]benzoate
  参考文献：
  名称：

  Synthesis and anti-platelet evaluation of 2-benzoylaminobenzoate analogs

  摘要：

  Fifty-two 2-benzoylaminobenzoate analogs were synthesized and subjected to anti-platelet aggregation assay using arachidonic acid (AA), collagen (Col), thrombin (Thr), and U46619 as inducers. The results revealed that most of 2-benzoylaminobenzoic acid derivatives showed a selectively inhibitory effect on AA-induced platelet aggregation. As a result of the 2-benzoylaminobenzoic acid derivatives (18, 44, and 46), there were no inhibitory effects on platelet aggregation induced by U46619, but these elicited an inhibitory effect on thromboxane B-2 formation at 1.0 mu M. These 2-benzoylaminobenzoate analogs were therefore proposed as cyclooxygenase inhibitors. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.03.071
• 作为产物：
  描述：

  丙醇 、 2-氨基-4-氟苯甲酸 在 磺酰氯 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 生成 Propyl 2-amino-4-fluorobenzoate
  参考文献：
  名称：

  Synthesis and anti-platelet evaluation of 2-benzoylaminobenzoate analogs

  摘要：

  Fifty-two 2-benzoylaminobenzoate analogs were synthesized and subjected to anti-platelet aggregation assay using arachidonic acid (AA), collagen (Col), thrombin (Thr), and U46619 as inducers. The results revealed that most of 2-benzoylaminobenzoic acid derivatives showed a selectively inhibitory effect on AA-induced platelet aggregation. As a result of the 2-benzoylaminobenzoic acid derivatives (18, 44, and 46), there were no inhibitory effects on platelet aggregation induced by U46619, but these elicited an inhibitory effect on thromboxane B-2 formation at 1.0 mu M. These 2-benzoylaminobenzoate analogs were therefore proposed as cyclooxygenase inhibitors. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.03.071

文献信息

• Synthesis and anti-platelet evaluation of 2-benzoylaminobenzoate analogs
  作者：Pei-Wen Hsieh、Shin-Zan Chiang、Chin-Chung Wu、Yi-Ching Lo、Yu-Tzu Shih、Yang-Chang Wu

  DOI：10.1016/j.bmc.2008.03.071

  日期：2008.5

  Fifty-two 2-benzoylaminobenzoate analogs were synthesized and subjected to anti-platelet aggregation assay using arachidonic acid (AA), collagen (Col), thrombin (Thr), and U46619 as inducers. The results revealed that most of 2-benzoylaminobenzoic acid derivatives showed a selectively inhibitory effect on AA-induced platelet aggregation. As a result of the 2-benzoylaminobenzoic acid derivatives (18, 44, and 46), there were no inhibitory effects on platelet aggregation induced by U46619, but these elicited an inhibitory effect on thromboxane B-2 formation at 1.0 mu M. These 2-benzoylaminobenzoate analogs were therefore proposed as cyclooxygenase inhibitors. (C) 2008 Elsevier Ltd. All rights reserved.