methyl 3-amino-4-hydroxyphenyl-α-methylacetate | 78587-73-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 3-amino-4-hydroxyphenyl-α-methylacetate
• 英文别名: Methyl 2-(3-amino-4-hydroxyphenyl)propanoate
• CAS: 78587-73-2
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: WPFIQHZPCUAEJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-溴苯基乙醛酸乙酯 、 methyl 3-amino-4-hydroxyphenyl-α-methylacetate 以58%的产率得到3-(4-Bromophenyl)-alpha-methyl-2-oxo-2H-1,4-benzoxazine-6-acetic acid methyl ester
  参考文献：
  名称：

  Shridhar, D. R.; Sastry, C. V. Reddy; Lal, B., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 4, p. 311 - 313

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 2-(3-nitro-4-hydroxyphenyl)propionate 以90%的产率得到methyl 3-amino-4-hydroxyphenyl-α-methylacetate
  参考文献：
  名称：

  Shridhar, D. R.; Sastry, C. V. Reddy; Lal, B., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 4, p. 311 - 313

  摘要：

  DOI：

文献信息

• 2-Aminophenol derivatives
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP0081321A1

  公开（公告）日：1983-06-15

  2-AMINOPHENOL derivatives of the general formula: [wherein Z represents a straight alkylene or alkenylene group containing from 1 to 6 carbon atom(s), R1 represents a hydrogen atom, a halogen atom, a straight or branched chain alkyl group containing from 1 to 6 carbon atom(s), a straight or branched chain alkoxy group containing from 1 to 4 carbon atom(s) or a group represented by general formula: (wherein R4 represents a hydrogen atom or a straight or branched chain alkyl group containing from 1 to 6 carbon atom(s).), R2 represents a hydrogen atom, a straight or branched chain alkyl group containing from 1 to 4 carbon atom(s) or a group represented by a formula: R' is attached to the 6th or 4th position of the benzene ring: when R' is attached to the 6th position of the benzene ring, Z-COOR2 is attached to the 4th position of the benzene ring, and when R' is attached to the 4th position of the benzene ring, Z-COOR2 is attached to the 6th position of the benzene ring.] and pharmaceutically acceptable acid addition salts thereof, possess a strong inhibitory effect on 5-lipoxygenase specifically, or 5-lipoxygenase and cyclooxygenase at the same time, and therefore, are useful as treating and preventing agents for diseases which induced by leukotrienes, e.g. allergic tracheal and bronchial diseases or allergic lung diseases, allergic shocks or various allergic inflammations, and various inflammations induced by prostaglandins.

  通式如下的 2-氨基苯酚衍生物： [其中 Z 代表含 1 至 6 个碳原子的直链亚烷基或烯基，R1 代表氢原子、卤素原子、含 1 至 6 个碳原子的直链或支链烷基、含 1 至 4 个碳原子的直链或支链烷氧基或通式如下的基团： (其中 R4 代表氢原子或含有 1 至 6 个碳原子的直链或支链烷基），R2 代表氢原子、含有 1 至 4 个碳原子的直链或支链烷基或由通式表示的基团： R'连接到苯环的第6位或第4位：当R'连接到苯环的第6位时，Z-COOR2连接到苯环的第4位；当R'连接到苯环的第4位时，Z-COOR2连接到苯环的第6位]。 本品及其药学上可接受的酸加成盐对特异性 5-脂氧合酶或同时对 5-脂氧合酶和环氧合酶有很强的抑制作用，因此可作为治疗和预防由白三烯诱发的疾病的药物，如过敏性气管和支气管疾病或过敏性肺部疾病、过敏性休克或各种过敏性炎症以及由前列腺素诱发的各种炎症。
• Shridhar, D. R.; Reddy Sastry, C. V.; Lal, B., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 1102 - 1103
  作者：Shridhar, D. R.、Reddy Sastry, C. V.、Lal, B.

  DOI：——

  日期：——
• SHRIDHAR, D. R.;SASTRY, C. V. R.;LAL, B.;SINGH, P. P.;RAO, C. S.;JUNNARKA+, INDIAN J. CHEM., 1981, 20, N 4, 311-313
  作者：SHRIDHAR, D. R.、SASTRY, C. V. R.、LAL, B.、SINGH, P. P.、RAO, C. S.、JUNNARKA+

  DOI：——

  日期：——
• US3985763A
  申请人：——

  公开号：US3985763A

  公开（公告）日：1976-10-12
• Shridhar, D. R.; Sastry, C. V. Reddy; Lal, B., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. <B> 20, # 4, p. 311 - 313
  作者：Shridhar, D. R.、Sastry, C. V. Reddy、Lal, B.、Singh, P. P.、Rao, C. Seshagiri、Junnarkar, A. Y.

  DOI：——

  日期：——