1-(2-(2-chloro-10,11-dihydrodibenzothiepin-10-ylthio)ethyl)-4-methylpiperazine | 134873-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫平类
• 英文名称: 1-(2-(2-chloro-10,11-dihydrodibenzothiepin-10-ylthio)ethyl)-4-methylpiperazine
• 英文别名: 1-(2-((2-Chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)thio)ethyl)-4-methylpiperazine；1-[2-[(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-6-yl)sulfanyl]ethyl]-4-methylpiperazine
• CAS: 134873-28-2
• 化学式: C₂₁H₂₅ClN₂S₂
• 分子量: 405.028
• InChiKey: JZTQXLGXJLBLFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-(2-氯-10,11-二氢二苯并[b,f]硫杂卓-10-基)-1-哌嗪乙醇 在 sodium hydroxide 、 lithium aluminium tetrahydride 、 sodium ethanolate 、 氯甲酸乙酯 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 、 水 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 20.0h， 生成 1-(2-(2-chloro-10,11-dihydrodibenzothiepin-10-ylthio)ethyl)-4-methylpiperazine
  参考文献：
  名称：

  Valenta, Vladimir; Vlkova, Marie; Protiva, Miroslav, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 5, p. 1403 - 1421

  摘要：

  DOI：

文献信息

• VALENTA, VLADIMIR;VLKOVA, MARIE;PROTIVA, MIROSLAV, COLLECT. CZECHOSL. CHEM. COMMUN., 54,(1989) N, C. 1403-1421
  作者：VALENTA, VLADIMIR、VLKOVA, MARIE、PROTIVA, MIROSLAV

  DOI：——

  日期：——
• PROTIVA, MIROSLAV;VALENTA, VLADIMIR;HOLA, VLADISLAVA
  作者：PROTIVA, MIROSLAV、VALENTA, VLADIMIR、HOLA, VLADISLAVA

  DOI：——

  日期：——
• METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCERS AND PATHOGENIC INFECTIONS
  申请人：Dunn William A.

  公开号：US20120141491A1

  公开（公告）日：2012-06-07

  The subject application provides small compounds that are able to increase/enhance autophagy in various cells. These compounds are useful in augmenting existing treatments of various cancers, microbial/viral infections, and neurodegenerative diseases. Thus, the subject application also provides methods of treating various types of cancers, microbial/viral infections, and neurodegenerative diseases.
• [EN] METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCERS AND PATHOGENIC INFECTIONS<br/>[FR] MÉTHODES ET COMPOSITIONS POUVANT ÊTRE UTILISÉES DANS LE CADRE DU TRAITEMENT DES CANCERS ET DES INFECTIONS PATHOGÈNES
  申请人：UNIV FLORIDA

  公开号：WO2011019636A2

  公开（公告）日：2011-02-17

  The subject application provides small compounds that are able to increase/enhance autophagy in various cells. These compounds are useful in augmenting existing treatments of various cancers, microbial/viral infections, and neurodegenerative diseases. Thus, the subject application also provides methods of treating various types of cancers, microbial/viral infections, and neurodegenerative diseases.
• Valenta, Vladimir; Vlkova, Marie; Protiva, Miroslav, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 5, p. 1403 - 1421
  作者：Valenta, Vladimir、Vlkova, Marie、Protiva, Miroslav

  DOI：——

  日期：——