tert-butyl ((1R,2R)-2-((4-hydroxybenzyl)(methyl)amino)cyclohexyl)carbamate | 1552279-35-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl ((1R,2R)-2-((4-hydroxybenzyl)(methyl)amino)cyclohexyl)carbamate
• CAS: 1552279-35-2
• 化学式: C₁₉H₃₀N₂O₃
• 分子量: 334.459
• InChiKey: GODDGYWNBJKRCZ-IAGOWNOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.66
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  61.8
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  tert-butyl ((1R,2R)-2-((4-hydroxybenzyl)(methyl)amino)cyclohexyl)carbamate 在 盐酸 、 水 作用下， 反应 12.0h， 生成
  参考文献：
  名称：

  Highly stereoselective direct aldol reactions catalyzed by a bifunctional chiral diamine

  摘要：

  The enantioselective organocatalytic direct aldol reactions of ketones with various aldehydes were developed by using chiral 1,2-cyclohexanediamine COACH) based multifunctional ligands via a noncovalent catalysis mechanism. By using a catalyst, we also obtained functionalized 3-alkyl-3-hydroxyindolin-2-ones in high yields and with good to excellent enantioselectivities. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2013.11.017
• 作为产物：
  描述：

  (1R,2R)-反式-N-Boc-1,2-二氨基环己烷 在 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 反应 7.5h， 生成 tert-butyl ((1R,2R)-2-((4-hydroxybenzyl)(methyl)amino)cyclohexyl)carbamate
  参考文献：
  名称：

  Highly stereoselective direct aldol reactions catalyzed by a bifunctional chiral diamine

  摘要：

  The enantioselective organocatalytic direct aldol reactions of ketones with various aldehydes were developed by using chiral 1,2-cyclohexanediamine COACH) based multifunctional ligands via a noncovalent catalysis mechanism. By using a catalyst, we also obtained functionalized 3-alkyl-3-hydroxyindolin-2-ones in high yields and with good to excellent enantioselectivities. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2013.11.017