1-(2-methoxyethoxymethoxy)-2-phenylpropan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-methoxyethoxymethoxy)-2-phenylpropan-2-ol
• 化学式: C₁₃H₂₀O₄
• 分子量: 240.299
• InChiKey: PVGPZSDJAZHRKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.53
• 重原子数：
  17.0
• 可旋转键数：
  8.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  47.92
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  2-甲氧基乙氧基甲基氯 、 2-苯基-1,2-丙二醇 在 N,N-二异丙基乙胺 作用下， 生成 1-(2-methoxyethoxymethoxy)-2-phenylpropan-2-ol
  参考文献：
  名称：

  Cleavage of MEM ethers by tetrahalozincate reagents

  摘要：

  A modification of the zinc halide-mediated removal of the MEM group is described. By the expedient of adding two molar equivalents of ethereal hydrogen chloride or of lithium halide, the method is extended to substrates which otherwise chelate the zinc reagent without undergoing deprotection. The compatibility of the resulting reagent systems with other functional groups is demonstrated, and examples are presented where deprotection of mono-MEM-protected 1,2- and 1,3-diols can be carried out, avoiding the cyclisation which occurs normally. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0040-4020(96)00930-1

文献信息

• Cleavage of MEM ethers by tetrahalozincate reagents
  作者：John M. Herbert、Julian G. Knight、Brian Sexton

  DOI：10.1016/s0040-4020(96)00930-1

  日期：1996.11

  A modification of the zinc halide-mediated removal of the MEM group is described. By the expedient of adding two molar equivalents of ethereal hydrogen chloride or of lithium halide, the method is extended to substrates which otherwise chelate the zinc reagent without undergoing deprotection. The compatibility of the resulting reagent systems with other functional groups is demonstrated, and examples are presented where deprotection of mono-MEM-protected 1,2- and 1,3-diols can be carried out, avoiding the cyclisation which occurs normally. Copyright (C) 1996 Elsevier Science Ltd