Methyl-(5-hydroxy-2.4-dimethyl-phenyl)-aether | 81633-94-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Methyl-(5-hydroxy-2.4-dimethyl-phenyl)-aether
• 英文别名: 6-Hydroxy-4-methoxy-m-xylol；5-Methoxy-2,4-dimethyl-phenol；4-Oxy-6-methoxy-1.3-dimethyl-benzol；5-Methoxy-2,4-dimethylphenol
• CAS: 81633-94-5
• 化学式: C₉H₁₂O₂
• 分子量: 152.193
• InChiKey: HFWQZZPQUOMMEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Methyl-(5-hydroxy-2.4-dimethyl-phenyl)-aether 、 三溴化硼 生成 2,4-dimethyl-5-hydroxyphenol
  参考文献：
  名称：

  GESSON, J. -P.;JACQUESY, J. -C.;JOUANNETAUD, M. -P., NOUV. J. CHIM., 1982, 6, N 10, 477-481

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4-dimethyl-5-methoxyaniline 在 硫酸 作用下， 生成 Methyl-(5-hydroxy-2.4-dimethyl-phenyl)-aether
  参考文献：
  名称：

  Tea as a Potential Chemopreventive Agent in PhIP Carcinogenesis: Effects of Green Tea and Black Tea on PhIP-DNA Adduct Formation in Female F-344 Rats

  摘要：

  The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed during the cooking of proteinaceous animal foods (meat, chicken, and fish). PhIP is a carcinogen in the Fischer 344 (F-344) rat; it induces mammary tumors in female rats and lymphomas and colon and prostate rumors in male rats. In F-344 rats, PhIP forms DNA adducts in various organs, including the target organs. Inhibition of PhIP-DNA adduct formation is likely to lead to inhibition of PhIP tumorigenicity. We have examined the chemopreventive properties of green tea and black tea in PhIP carcinogenesis by evaluating their effects on PhIP-DNA adduct formation in the female F-344 rat. Young adult animals were maintained on powdered AIN-76A diet while receiving regular drinking water or 2% (wt/vol) infusions of green tea or black tea for a total of six weeks. During Weeks 3, 4, and 5, all animals received PhIP by gavage (1 mg/kg/day). Three rats per group were euthanized on Days 1 and 8 after termination of PhIP exposure. DNA was isolated from a number of organs and analyzed for PhIP-DNA adducts by P-32-postlabeling assays. Compared with animals on regular drinking wafer, PhIP-DMA adduct formation was inhibited in small intestine, colon, liver, and mammary epithelial cells (MECS) of animals receiving green tea or black tea as the sole source of drinking fluid. Green tea inhibited adduct formation in colon, liver, and MECs (33.3-80.0%) on both days, but only on Day 8 (54.4%) in small intestine. Black tea inhibited adduct formation on both days in liver (71.4-80.0%), on Day 1 in colon (40.0%), and on Day 8 in small intestine (81.8%); it had no effect on MEC adducts. Neither green tea nor black tea had an effect on adduct levels in pancreas: lungs, white blood cells, heart, kidneys, spleen, cecum, or stomach. Similarly, these teas did not affect the rate of adduct removal (percent change from Day 1 to Day 8) in any organ. It is concluded that green tea and black tea are potential chemopreventive agents in PhIP-induced tumorigenesis in the F-344 rat.

  DOI：

  10.1207/s15327914nc3601_8

文献信息

• Derivatives of m-Guaiacol, Their Preparation and Their Uses
  申请人：Universite de Caen Normandie

  公开号：US20210337789A1

  公开（公告）日：2021-11-04

  The invention concerns derivatives of m-guaiacol, their preparation and their uses as biocides, in particular as antibacterials or disinfectants.

  这项发明涉及对m-石碱酚衍生物的制备及其用途，特别是作为抗菌剂或消毒剂。
• INHIBITORS OF SERINE PROTEASES
  申请人：Cottrell Kevin M.

  公开号：US20110182856A1

  公开（公告）日：2011-07-28

  The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof. These compounds inhibit serine protease, particularly the hepatitis C virus NS3-NS4A protease.

  本发明涉及式(I)化合物或其药学上可接受的盐。这些化合物抑制丝氨酸蛋白酶，特别是丙型肝炎病毒NS3-NS4A蛋白酶。
• Bamberger; Frei, Chemische Berichte, 1907, vol. 40, p. 1941
  作者：Bamberger、Frei

  DOI：——

  日期：——
• US7985762B2
  申请人：——

  公开号：US7985762B2

  公开（公告）日：2011-07-26
• US7964624B1
  申请人：——

  公开号：US7964624B1

  公开（公告）日：2011-06-21