N,N-dimethylperimidine-1-propylamine | 59283-17-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类 - 二氮杂萘
• 英文名称: N,N-dimethylperimidine-1-propylamine
• 英文别名: dimethyl-(3-perimidin-1-yl-propyl)-amine；1-<3-Dimethylamino-propyl>-perimidin；1H-Perimidine-1-propanamine, N,N-dimethyl-；N,N-dimethyl-3-perimidin-1-ylpropan-1-amine
• CAS: 59283-17-9
• 化学式: C₁₆H₁₉N₃
• 分子量: 253.347
• InChiKey: IOEKAWHPHVSZMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  18.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-dimethylperimidine-1-propylamine 以79%的产率得到
  参考文献：
  名称：

  SHEJNKMAN A. K.; POZHARSKIJ A. F.; SOKOLOV V. I.; STUPNIKOVA T. V., DOKL. AN CCCP , 1976, 226, HO 5, 1094-1096

  摘要：

  DOI：
• 作为产物：
  描述：

  呸啶 、 N,N-二甲氨基氯丙烷盐酸盐 以 氯苯 、 甲苯 为溶剂， 反应 4.0h， 以49%的产率得到N,N-dimethylperimidine-1-propylamine
  参考文献：
  名称：

  Potential antitumor agents. 53. Synthesis, DNA binding properties, and biological activity of perimidines designed as minimal DNA-intercalating agents

  摘要：

  A series of compounds based on perimidine have been synthesized and evaluated for their DNA-binding properties and antitumor activity. The fused tricyclic permidine chromophore appears to be the minimal structural requirement for intercalative binding to DNA since the mode of binding could be dictated by the position of attachment of the side chain. The intercalating compounds have DNA association constants (log K = 5.8-6.5) and cytotoxic potencies (IC50 = 500-1500 nM) comparable to those shown by other classes of linear, tricyclic DNA-intercalating antitumor agents (acridinecarboxamides, phenazinecarboxamides), but none of the compounds showed in vivo activity.

  DOI：

  10.1021/jm00394a025

文献信息

• POZHARSKIJ A. F.; KOMISSAROV I. V.; FILIPPOV I. T.; KONSTANTINCHENKO A. A+, XIM.-FARMATSEVT. ZH., 1977, 11, HO 5, 87-93
  作者：POZHARSKIJ A. F.、 KOMISSAROV I. V.、 FILIPPOV I. T.、 KONSTANTINCHENKO A. A+

  DOI：——

  日期：——
• KOMISSAROV I. V.; KONSTANTINCHENKO A. A.; POZHARSKIJ A. F.; FILIPPOV I. T+, XIM.-FARMATSEVT. ZH. <KNFZ-AN>, 1976, 10, HO 7, 28-33
  作者：KOMISSAROV I. V.、 KONSTANTINCHENKO A. A.、 POZHARSKIJ A. F.、 FILIPPOV I. T+

  DOI：——

  日期：——
• [EN] OXIDATIVE DYEING COMPOSITION COMPRISING A SPECIFIC PERIMIDINE COUPLER IN A MEDIUM WITH HIGH FATTY SUBSTANCE CONTENT, METHODS AND SUITABLE DEVICE<br/>[FR] COMPOSITION DE COLORATION D'OXYDATION COMPRENANT UN COUPLEUR PERIMIDINE SPÉCIFIQUE DANS UN MILIEU À TENEUR ÉLEVÉE EN CORPS GRAS, PROCÉDÉS ET DISPOSITIF ADAPTÉ
  申请人：OREAL

  公开号：WO2013087634A2

  公开（公告）日：2013-06-20

  Oxidative dyeing composition comprising a specific perimidine coupler in a medium with high fatty substance content, methods and suitable device The present invention relates to an oxidative dyeing composition for keratin fibres, in particular human keratin fibres such as the hair, comprising: - at least 25% by weight, relative to the total weight of the composition, of one or more fatty substances, - one or more surfactants, - one or more alkaline agents, - one or more oxidation bases, and - one or more perimidine couplers chosen from compounds having the following formula (I), their addition salts, their isomers, their tautomers, their solvates and their dimers: The invention also relates to methods using the composition according to the invention and to a multi-compartment device.
• Potential antitumor agents. 53. Synthesis, DNA binding properties, and biological activity of perimidines designed as minimal DNA-intercalating agents
  作者：John M. Herbert、Paul D. Woodgate、William A. Denny

  DOI：10.1021/jm00394a025

  日期：1987.11

  A series of compounds based on perimidine have been synthesized and evaluated for their DNA-binding properties and antitumor activity. The fused tricyclic permidine chromophore appears to be the minimal structural requirement for intercalative binding to DNA since the mode of binding could be dictated by the position of attachment of the side chain. The intercalating compounds have DNA association constants (log K = 5.8-6.5) and cytotoxic potencies (IC50 = 500-1500 nM) comparable to those shown by other classes of linear, tricyclic DNA-intercalating antitumor agents (acridinecarboxamides, phenazinecarboxamides), but none of the compounds showed in vivo activity.
• SHEJNKMAN A. K.; POZHARSKIJ A. F.; SOKOLOV V. I.; STUPNIKOVA T. V., DOKL. AN CCCP <DANK-AS>, 1976, 226, HO 5, 1094-1096
  作者：SHEJNKMAN A. K.、 POZHARSKIJ A. F.、 SOKOLOV V. I.、 STUPNIKOVA T. V.

  DOI：——

  日期：——