2-((5-bromo-1H-indol-3-yl)methyl)-1-(naphthalen-2-yl)-1H-benzo[f]chromen-3-amine | 1400570-71-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 2-((5-bromo-1H-indol-3-yl)methyl)-1-(naphthalen-2-yl)-1H-benzo[f]chromen-3-amine
• 英文别名: (3-amino-1-naphthalen-2-yl-1H-benzo[f]chromen-2-yl)-(5-bromo-1H-indol-3-yl)methanone
• CAS: 1400570-71-9
• 化学式: C₃₂H₂₁BrN₂O₂
• 分子量: 545.435
• InChiKey: RKXMZNIWLKQBAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  37
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  68.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(5-bromo-1H-indol-3-yl)-3-oxopropanenitrile 、 2-萘甲醛 、 2-萘酚 在 三乙胺 作用下， 以 甲醇 为溶剂， 反应 0.07h， 以70%的产率得到2-((5-bromo-1H-indol-3-yl)methyl)-1-(naphthalen-2-yl)-1H-benzo[f]chromen-3-amine
  参考文献：
  名称：

  An expeditious regioselective synthesis of novel bioactive indole-substituted chromene derivatives via one-pot three-component reaction

  摘要：

  Novel fused 1H-benzo[f]chromen-indole derivatives were synthesized regioselectivly in good to high yields by triethyl amine catalyzed condensation of 3-cyanoacetylindoles, beta-naphthol and aryl aldehydes in methanol under ultrasounic irradiations and conventional conditions. The easy work-up of the products, rapidity, and mild reaction conditions are notable features of this protocol. The antibacterial activity of the selected products was examined. Some products showed promising activities. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.07.059

文献信息

• An expeditious regioselective synthesis of novel bioactive indole-substituted chromene derivatives via one-pot three-component reaction
  作者：Roghayeh Hossein nia、Manouchehr Mamaghani、Khalil Tabatabaeian、Farhad Shirini、Mehdi Rassa

  DOI：10.1016/j.bmcl.2012.07.059

  日期：2012.9

  Novel fused 1H-benzo[f]chromen-indole derivatives were synthesized regioselectivly in good to high yields by triethyl amine catalyzed condensation of 3-cyanoacetylindoles, beta-naphthol and aryl aldehydes in methanol under ultrasounic irradiations and conventional conditions. The easy work-up of the products, rapidity, and mild reaction conditions are notable features of this protocol. The antibacterial activity of the selected products was examined. Some products showed promising activities. (C) 2012 Elsevier Ltd. All rights reserved.