2-(2,6-dimethoxy-phenyl)-oxazolidin-4-one | 1255787-55-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,6-dimethoxy-phenyl)-oxazolidin-4-one
• 英文别名: 2-(2,6-dimethoxyphenyl)-1,3-oxazolidin-4-one
• CAS: 1255787-55-3
• 化学式: C₁₁H₁₃NO₄
• 分子量: 223.229
• InChiKey: YKYBCRXCQOMROO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  羟基乙酰胺 、 2,6-二甲氧基苯甲醛 生成 2-(2,6-dimethoxy-phenyl)-oxazolidin-4-one
  参考文献：
  名称：

  Oxazolidinone derivatives

  摘要：

  本发明涉及式（I）的噁唑烷衍生物，其中Y，R3和R4如描述中所述，以及其制备方法，其药学上可接受的盐，以及它们作为药物的用途，含有一个或多个式（I）的化合物的制药组合物，特别是它们作为觉醒素受体拮抗剂的用途。

  公开号：

  US08329706B2

文献信息

• NOVEL OXAZOLIDINONE DERIVIATIVES
  申请人：Aissaoui Hamed

  公开号：US20120101111A1

  公开（公告）日：2012-04-26

  The present invention relates to oxazolidinone derivatives of formula (I) wherein Y, R 3 and R 4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.

  本发明涉及式(I)的噁唑烷酮衍生物，其中Y、R3和R4如描述中所述，以及它们的制备方法，它们的药用盐，以及它们作为药物的用途，包括含有一个或多个式(I)化合物的药物组合物，特别是它们作为促进睡眠的药物受体拮抗剂的用途。
• Oxazolidinone derivatives
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：US08329706B2

  公开（公告）日：2012-12-11

  The present invention relates to oxazolidinone derivatives of formula (I) wherein Y, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.

  本发明涉及式（I）的噁唑烷衍生物，其中Y，R3和R4如描述中所述，以及其制备方法，其药学上可接受的盐，以及它们作为药物的用途，含有一个或多个式（I）的化合物的制药组合物，特别是它们作为觉醒素受体拮抗剂的用途。
• US8329706B2
  申请人：——

  公开号：US8329706B2

  公开（公告）日：2012-12-11
• [EN] NOVEL OXAZOLIDINONE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS OXAZOLIDINONE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2010131192A2

  公开（公告）日：2010-11-18

  The present invention relates to oxazolidinone derivatives of formula (I) wherein Y, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.
• NOVEL OXAZOLIDINONE DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP2430004B1

  公开（公告）日：2013-07-17