2-amino-3-(2'-quinoxalyl)propionic acid | 92289-91-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-amino-3-(2'-quinoxalyl)propionic acid
• 英文别名: 2-amino-3-quinoxalin-2-yl-propionic acid；2-Amino-3-chinoxalin-2-yl-propionsaeure；(+/-)-β-(2-quinoxalinyl)-α-alanine；2-Amino-3-(quinoxalin-2-yl)propanoic acid；2-amino-3-quinoxalin-2-ylpropanoic acid
• CAS: 92289-91-3
• 化学式: C₁₁H₁₁N₃O₂
• 分子量: 217.227
• InChiKey: AVZRALYARGQMPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  89.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  甲醇 、 2-amino-3-(2'-quinoxalyl)propionic acid 在 氯化亚砜 作用下， 生成 Methyl 2-amino-3-quinoxalin-2-ylpropanoate
  参考文献：
  名称：

  Intercalator amino acids : Synthesis of heteroaryl alanines

  摘要：

  Stereoselective alkylation of (S)-(-)-2-t-butyl-1-t-butyloxycarbonyl-3-methyl-4-imidazolinone with 2-chloromethylquinoline, 2-chloromethylquinoxaline and 5-chloromethyl-1,10-phenanthroline, followed by hydrolysis, afforded the corresponding (S)-(+)-alpha-amino acids with high enantiomeric excess.

  DOI：

  10.1016/0957-4166(94)80088-x
• 作为产物：
  描述：

  3,6-bis-quinoxalin-2-ylmethyl-piperazine-2,5-dione 在 盐酸 作用下， 生成 2-amino-3-(2'-quinoxalyl)propionic acid
  参考文献：
  名称：

  Ried; Schiller, Chemische Berichte, 1953, vol. 86, p. 730,734

  摘要：

  DOI：

文献信息

• Method for producing ss-heteroaryl-alpha-alanine compounds using 2-amino-2-(heteroarylmethyl) carboxylic acid compounds
  申请人：Oehlinger Stefan

  公开号：US20050080263A1

  公开（公告）日：2005-04-14

  This invention relates to N and O-protected, optionally substituted β-heteroaryl-α-alanine compounds and N and O-protected or N or O-protected, optionally substituted 2-amino-2-(heteroarylmethyl)-carboxylic acid compounds, methods for their production, and the use of N and O-protected or N or O-protected, optionally substituted 2-amino-2-(heteroarylmethyl)-carboxylic acid compounds for producing N-protected, optionally substituted β-heteroaryl-α-alanine compounds.

  这项发明涉及N和O保护的、可选择取代的β-杂环烷基-α-丙氨酸化合物以及N和O保护或N或O保护的、可选择取代的2-氨基-2-(杂环烷基甲基)-羧酸化合物，其生产方法，以及利用N和O保护或N或O保护的、可选择取代的2-氨基-2-(杂环烷基甲基)-羧酸化合物来生产N保护的、可选择取代的β-杂环烷基-α-丙氨酸化合物。
• [EN] PEPTIDES TARGETING SHP2 AND USES THEREOF<br/>[FR] PEPTIDES CIBLANT SHP2 ET LEURS UTILISATIONS
  申请人：UNIV DEGLI STUDI DI ROMA TOR VERGATA

  公开号：WO2021176072A1

  公开（公告）日：2021-09-10

  The present invention relates to a peptide comprising or consisting of the sequence from N- terminus to C-terminus X-2X-1ZX1X2X3X4X5 wherein - Z is tyrosine, phosphotyrosine or a non-natural analogue of phosphotyrosine, such as phosphonodifluoromethyl phenylalanine (F2Pmp) - X-2 is a hydrophobic amino acid, preferably selected from the group consisting of: Leu, Ile, Val, Phe, Tyr, Trp and Met - X-1 is any amino acid - X1 is a hydrophobic amino acid, preferably selected from the group consisting of: Ile, Leu, Val, Phe, Tyr, Trp and Met - X3 is a hydrophobic amino acid, preferably selected from the group consisting of: Leu, Ile, Val, Phe, Tyr, Trp and Met - X5 is a hydrophobic amino acid, preferably selected from the group consisting of: Trp, Ile, Val, Phe, Tyr, and Met - X2 and X4 are anionic amino acids, preferably each independently is Asp or Glu. The peptide inhibits protein-protein interactions of the Src homology 2 domain-containing phosphatase 2 (SHP2), for the treatment of cancer and RASopathies and as a biomedical research tool.
• Intercalator amino acids : Synthesis of heteroaryl alanines
  作者：Guy Y. Krippner、Margaret M. Harding

  DOI：10.1016/0957-4166(94)80088-x

  日期：1994.9

  Stereoselective alkylation of (S)-(-)-2-t-butyl-1-t-butyloxycarbonyl-3-methyl-4-imidazolinone with 2-chloromethylquinoline, 2-chloromethylquinoxaline and 5-chloromethyl-1,10-phenanthroline, followed by hydrolysis, afforded the corresponding (S)-(+)-alpha-amino acids with high enantiomeric excess.
• Ried; Schiller, Chemische Berichte, 1953, vol. 86, p. 730,734
  作者：Ried、Schiller

  DOI：——

  日期：——