4-(2-hydroxyethyl)sulfonylaniline hydrochloride | 4229-23-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-hydroxyethyl)sulfonylaniline hydrochloride
• 英文别名: 2-sulfanilyl-ethanol; hydrochloride；2-Sulfanilyl-aethanol; Hydrochlorid；2-(4-Aminobenzenesulfonyl)ethan-1-ol hydrochloride；2-(4-aminophenyl)sulfonylethanol;hydrochloride
• CAS: 4229-23-6
• 化学式: C₈H₁₁NO₃S*ClH
• mdl: MFCD00220174
• 分子量: 237.707
• InChiKey: XPLFFSLHKSFPHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.55
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  88.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(2-hydroxyethyl)sulfonylaniline hydrochloride 在 sodium hydroxide 、 硫酸 作用下， 反应 0.75h， 生成 2-(4-Ethenesulfonyl-phenylazo)-benzene-1,3,5-triol
  参考文献：
  名称：

  Optical sensor arrays: one-pot, multiparallel synthesis and cellulose immobilization of pH and metal ion sensitive azo-dyes

  摘要：

  A sixteen component array of acid-base and metal ion sensors was synthesized and covalently immobilized onto a transparent cell ulose-based membrane. Dye synthesis and cellulose dyeing were carried Out in one-pot, parallel, microscale reactions not requiring any isolation or purification steps. In addition, pH and metal ion optical sensing properties of the sixteen component array have been tested using a high-throughput screening based on digital imaging analysis. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.11.016
• 作为产物：
  描述：

  N-(4-((2-羟乙基)磺酰)苯基)乙酰胺 在 盐酸 、 水 作用下， 生成 4-(2-hydroxyethyl)sulfonylaniline hydrochloride
  参考文献：
  名称：

  SULFONES. III. 4-AMINOPHENYL ALKYL SULFONES

  摘要：

  DOI：

  10.1021/jo01148a029

文献信息

• [EN] PYRROLE-2,5-DIONE DERIVATIVES FOR THE TREATMENT OF DIABETES<br/>[FR] DERIVES DE PYRROLE-2, 5-DIONE DESTINES AU TRAITEMENT DU DIABETE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2001074771A1

  公开（公告）日：2001-10-11

  A method for the treatment of conditions associated with a need for inhibition of GSK-3, which method comprises the administration of a pharmaceutically effective, non-toxic amount of a compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein R1 is a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring, which ring may be fused to a substituted or unsubstituted carbocyclic or heterocyclic aromatic or non-aromatic ring; R2 is a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring, which ring may be fused to a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring, with the proviso that R2 is not 3-indolyl or a fused-ring derivative of 3-indolyl; R3 is hydrogen, or R?1 and R3¿ together with the nitrogen atom to which they are attached form a fused substituted or unsubstituted heterocylic ring; to a human or non-human mammal in need thereof.

  一种用于治疗需要抑制GSK-3的病症的方法，该方法包括向需要治疗的人类或非人哺乳动物中投与一种公认为药用的衍生物或化合物(I)的有效、非毒性剂量，其中R1是取代或未取代的碳环或杂环芳香环，该环可能与取代或未取代的碳环或杂环芳香环或非芳香环融合；R2是取代或未取代的碳环或杂环芳香环，该环可能与取代或未取代的碳环或杂环芳香环融合，但R2不是3-吲哚基或3-吲哚基的融合环衍生物；R3是氢，或R1和R3与它们连接的氮原子一起形成融合的取代或未取代的杂环环。
• Chromophore Structure, Second Harmonic Generation, and Orientational Order in Zirconium Phosphonate/Phosphate Self-Assembled Multilayers
  作者：H. E. Katz、W. L. Wilson、G. Scheller

  DOI：10.1021/ja00094a019

  日期：1994.7

  Two new phosphonate-terminated polar azo dyes, one that is substantially rigid (1) and the other with a large molecular hyperpolarizability (2), were designed and incorporated into zirconium-based surface multilayers. Second harmonic generation (SHG) was observed from the multilayers as a function of incident and polarization angles and compared with that from the previously reported aminophenylazophenylphosphonic acid chromophore 3. The new dyes are analogous to moieties commonly used in electric field-poled polymers, allowing comparisons between the polymers and the multilayers. Apparent order parameters (cos(3) theta) are >0.2 for 1 and approximate to 0.16 for 2. Because of local field effects, the value for 1 is probably a lower limit. Use of other dyes that are both rigid and highly polar led to H-aggregation. Insertion of a nonpolar chromophore layer among the polar layers had no effect on SHG. The syntheses involved several novel reactions, involving the preparation of an unsymmetrically substituted diphenylpiperazine, an anilinoalkyl phosphonate, and the deprotected phosphonic acids themselves.