2-vinylquinazoline | 1305318-29-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-vinylquinazoline
• 英文别名: Chinazolyl-ethylen；2-ethenylquinazoline
• CAS: 1305318-29-9
• 化学式: C₁₀H₈N₂
• 分子量: 156.187
• InChiKey: JXUYHTCQKHJDBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-vinylquinazoline 在 盐酸 、 potassium permanganate 、 potassium tert-butylate 作用下， 以 二氯甲烷 、 水 为溶剂， 以27%的产率得到2-(1-chlorovinyl)quinazoline
  参考文献：
  名称：

  通过催化生成的烯胺的对映选择性质子化不对称合成杂环氯胺和氮丙啶**

  摘要：

  布朗斯台德酸催化能够通过催化产生的前手性氯烯胺的不对称质子化来合成手性邻位氯胺。该过程具有高度对映选择性，通过 DFT 计算阐明了不对称性的起源和催化剂取代基效应。该方法允许获得稀有的杂环取代的邻位氯胺、氮丙啶和邻位二胺。

  DOI：

  10.1002/chem.202200060
• 作为产物：
  描述：

  2-氯喹唑啉 、 三丁基乙烯基锡 在 tris-(dibenzylideneacetone)dipalladium(0) 、 三叔丁基膦 作用下， 以 甲苯 为溶剂， 反应 3.0h， 生成 2-vinylquinazoline
  参考文献：
  名称：

  涉及乙烯基取代的嘧啶、喹喔啉和喹唑啉的超强酸促进添加：与电荷分布相关的机制

  摘要：

  已经研究了乙烯基取代的 N-杂环的超酸促进反应。双质子化嘧啶、喹喔啉和喹唑啉表现出不寻常的区域电子效应，可控制所观察到的加成反应类型。根据乙烯基取代基的环位置，发生共轭加成或马尔可夫尼科夫加成。添加方式已被证明与 NBO 计算的费用相关。

  DOI：

  10.1021/ja202557z

文献信息

• Michael Additions Involving Amino Acid Esters with Alkenyl N-Heterocycles
  作者：Sean H. Kennedy、Douglas A. Klumpp

  DOI：10.1021/acs.joc.7b01724

  日期：2017.10.6

  variety of amino acid esters and 2- or 4-vinylpyridine. Similar reactions were accomplished with an alkenyl-substituted pyrimidine, pyrazine, thiazole, quinoxaline, benzoxazole, and quinolone. In reactions at a prochiral center, modest diastereoselectivities were observed with the formation of the new stereogenic carbon. NMR experiments indicate that the addition reaction is reversible under acidic conditions

  用多种氨基酸酯和2-或4-乙烯基吡啶可实现迈克尔加成。用烯基取代的嘧啶，吡嗪，噻唑，喹喔啉，苯并恶唑和喹诺酮可以完成类似的反应。在前手性中心的反应中，观察到适度的非对映选择性，并形成了新的立体异构碳。NMR实验表明加成反应在酸性条件下是可逆的。
• Layer configuration comprising an electron-blocking element
  申请人：AGFA-GEVAERT

  公开号：US20040044214A1

  公开（公告）日：2004-03-04

  A layer configuration on a support, the layer configuration comprising a non-photoactive element exclusive of poly(3,4-alkylenedioxythiophene)s and poly(3,4-dialkoxythiophene)s, the element containing a first polymer containing structural units according to formula (I): 1 in which X and Y are independently O, S, N—R 1 , Z is —(CH 2 ) m CR 2 R 3 —(CH 2 ) n —; R 1 is aryl, C 1-18 -alkyl or hydrogen; R 2 is hydrogen or —(CH 2 ) s —O—(CH 2 ) p —SO 3 − M + ; R 3 is —(CH 2 ) s —O—(CH 2 ) p —SO 3 − M + ; M + is a cation; m and n are independently a whole number from 0 to 3; s is a whole number from 0 to 10; and p is a whole number from 1 to 18, and a second polymer different from the first polymer and selected from the group consisting of optionally quaternized polyamine-polymers, polysulpho-polymers, polyphosphoric acids and polyphosphoric acid salts, the surface of one side of the element being contiguous with a positive electrode and the surface on the opposite side of the element being contiguous with a material capable of transporting holes.

  一种在支撑物上的层配置，该层配置包括一种独立于聚（3,4-烷基二氧硫杂噻吩）和聚（3,4-二烷氧基噻吩）的非光致元素，该元素包含第一种聚合物，该聚合物含有根据公式（I）的结构单元：1其中X和Y独立地为O，S，N-R1，Z为-(CH2)mCR2R3-(CH2)n-; R1为芳香族，C1-18-烷基或氢; R2为氢或-(CH2)s-O-(CH2)p-SO3-M+; R3为-(CH2)s-O-(CH2)p-SO3-M+; M+为阳离子; m和n分别为0到3的整数; s为0到10的整数; p为1到18的整数，并且第二种聚合物与第一种聚合物不同，选自可选的季铵化聚胺聚合物，聚磺酸聚合物，聚磷酸和聚磷酸盐的组中选择，元素的一侧表面与正极相邻，元素的另一侧表面与能够传输空穴的材料相邻。
• Aggregating compositions, modified particulate metal-oxides, modified formation surfaces, and methods for making and using same
  申请人：Clearwater International LLC

  公开号：EP2251394A2

  公开（公告）日：2010-11-17

  A method for treating solid materials is disclosed, where the treating compositions coats surfaces or portions of surfaces of the solid materials changing an aggregation or agglomeration propensity of the materials. Treating composition and treated solid materials are also disclosed. The methods and treated materials are ideally suited for oil field applications.

  本发明公开了一种处理固体材料的方法，其中处理组合物涂覆在固体材料的表面或部分表面上，改变了材料的聚集或团聚倾向。还公开了处理组合物和处理过的固体材料。这些方法和处理过的材料非常适合油田应用。
• Composite solids system to prepare polymer solutions for hydraulic fracturing treatments
  申请人：Trican Well Service Ltd.

  公开号：EP2660298A1

  公开（公告）日：2013-11-06

  A method of reducing the cost and environmental impact of chemicals used in hydraulic fracturing is to use multiple chemicals that are pre-mixed and then formed into a single solid blended mixture. By forming at least two chemicals into a single solid mixture, the complexity involved in transporting multiple solid or liquid chemicals is avoided. If the solid chemicals were merely premixed they would tend to segregate during shipping, handling, and storage altering the concentration of the chemical mix as it is pumped downhole. Simply having less equipment on the wellsite increases the accuracy of the well treating process and decreases the likelihood of a time consuming and thus costly delay due to equipment failure.

  降低水力压裂所用化学品的成本和环境影响的一种方法是使用预先混合的多种化学品，然后将其形成单一的固体混合混合物。通过将至少两种化学品混合成单一固体混合物，可以避免运输多种固体或液体化学品的复杂性。如果只是预先混合固体化学品，它们在运输、处理和储存过程中会发生分离，从而在井下泵送时改变混合化学品的浓度。只需在井场减少设备，就能提高油井处理过程的准确性，并降低因设备故障而造成耗时、代价高昂的延误的可能性。
• AGGREGATING COMPOSITIONS, MODIFIED PARTICULATE METAL OXIDES, MODIFIED FORMATION SURFACES, AND METHODS FOR MAKING AND USING SAME
  申请人：Lubrizol Oilfield Solutions, Inc.

  公开号：EP3138890A1

  公开（公告）日：2017-03-08

  A method for treating solid materials is disclosed, where the treating compositions coats surfaces or portions of surfaces of the solid materials changing an aggregation or agglomeration propensity of the materials. Treating composition and treated solid materials are also disclosed. The methods and treated materials are ideally suited for oil field applications.

  本发明公开了一种处理固体材料的方法，其中处理组合物涂覆在固体材料的表面或部分表面上，改变了材料的聚集或团聚倾向。还公开了处理组合物和处理过的固体材料。这些方法和处理过的材料非常适合油田应用。