beta-高甜菜碱甲酯高氯酸盐 | 16271-53-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: beta-高甜菜碱甲酯高氯酸盐
• 英文名称: acetylcholine
• 英文别名: trimethyl-(2-methoxycarbonyl-ethyl)-ammonium；3-Dimethylamino-propionsaeure-methylester-methohydroxyd；(2-Methoxycarbonyl-aethyl)-trimethyl-ammonium；3-Trimethylammonio-propionsaeure-methylester；Trimethyl-(2-carbomethoxy-aethyl)-ammonium；β-Dimethylamino-propionsaeure-methylester-jodmethylat；1-Propanaminium, 3-methoxy-N,N,N-trimethyl-3-oxo-；(3-methoxy-3-oxopropyl)-trimethylazanium
• CAS: 16271-53-7
• 化学式: C₇H₁₆NO₂
• 分子量: 146.21
• InChiKey: FHHONAJFFKMUQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2923900090

反应信息

• 作为反应物：
  描述：

  beta-高甜菜碱甲酯高氯酸盐 在 silver(l) oxide 作用下， 生成 三甲氨基丙酸内盐
  参考文献：
  名称：

  Willstaetter, Chemische Berichte, 1902, vol. 35, p. 602

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(二甲氨基)丙酸甲酯 、 碘甲烷 生成 beta-高甜菜碱甲酯高氯酸盐
  参考文献：
  名称：

  Willstaetter, Chemische Berichte, 1902, vol. 35, p. 602

  摘要：

  DOI：

文献信息

• Novel benzothiazepine and bensothiepine compounds
  申请人：Sasahara Takehiko

  公开号：US20070190041A1

  公开（公告）日：2007-08-16

  A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary sclerosing cholangitis, and a pharmaceutical useful as a therapeutic agent and a preventive agent for obesity, fatty liver and steatohepatitis are provided. A benzothiazepine or benzothiepine compound represented by the following formula (1A) having a thioamide bond and a quaternary ammonium substitutent:

  提供了一种药物，可用作治疗和预防高脂血症的治疗剂和预防剂，以及一种药物，可用作治疗和预防与胆汁淤积有关的肝脏疾病，特别是原发性胆汁性肝硬化和原发性硬化性胆管炎的治疗剂和预防剂，以及一种药物，可用作治疗和预防肥胖症、脂肪肝和脂肪性肝炎的治疗剂和预防剂。化合物的苯并噻吩或苯并噻环代表如下式（1A），具有硫酰胺键和季铵取代基：
• Novel quaternary ammonium compounds
  申请人：Sasahara Takehiko

  公开号：US20070203115A1

  公开（公告）日：2007-08-30

  A method for inhibiting ileal bile acid transporter activity in a subject, comprising administering to said subject an effective amount of a compound represented by formula (1):

  一种抑制回肠胆汁酸转运蛋白活性的方法，包括向该受试者施用一种由式（1）所代表的化合物的有效量：
• NOVEL BENZOTHIAZEPINE AND BENZOTHIEPINE COMPOUNDS
  申请人：SASAHARA Takehiko

  公开号：US20120015925A1

  公开（公告）日：2012-01-19

  A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary sclerosing cholangitis, and a pharmaceutical useful as a therapeutic agent and a preventive agent for obesity, fatty liver and steatohepatitis are provided. A benzothiazepine or benzothiepine compound represented by the following formula (1A) having a thioamide bond and a quaternary ammonium substituent:

  提供了一种作为治疗剂和预防剂用于高脂血症的药物，以及一种作为治疗剂和预防剂用于与胆汁淤积相关的肝疾病，特别是原发性胆汁性肝硬化和原发性硬化性胆管炎的药物，以及一种作为治疗剂和预防剂用于肥胖症、脂肪肝和脂肪性肝炎的药物。该药物是一种具有硫酰胺键和季铵基取代基的苯并噻吩或苯并噻吩化合物，其化学式为（1A）。
• LIQUID MEDIUM FOR PREVENTING CHARGE-UP IN ELECTRON MICROSCOPE AND METHOD OF OBSERVING SAMPLE USING THE SAME
  申请人：Hitachi High-Technologies Corporation

  公开号：EP3078962A1

  公开（公告）日：2016-10-12

  An object of the present invention is to provide a medium; a specimen; a method for preparing the specimen; a method for observing the specimen; a sample cell; and an electron microscope capable of easily solving the problem of charge-up and further capable of observing a real shape or the like of a sample with a SEM, a TEM or the like. For the purpose of achieving the above-described object, the present invention uses an electrical conductivity-imparting liquid medium, for use in a microscope, which includes an ionic liquid as an essential component thereof and is impregnated into the entirety of a SEM or TEM sample or applied to the observation surface of a SEM or TEM sample to impart electrical conductivity at least to the observation surface of the sample. According to the present invention, the charge built up on the sample surface can be released simply by impregnating or coating the sample with the ionic liquid, and hence the problem of charge-up can be easily solved. Further, even when a sample impregnated or coated with the ionic liquid is placed under vacuum, the ionic liquid is not evaporated from the sample, and hence a biological sample can be observed as it is in an original shape.

  本发明的目的是提供一种介质；一种试样；一种制备试样的方法；一种观察试样的方法；一种样品池；以及一种电子显微镜，该电子显微镜能够轻松解决充电问题，并能进一步利用扫描电镜、电子显微镜或类似装置观察试样的真实形状或类似形状。为了实现上述目的，本发明使用了一种用于显微镜的导电液体介质，其中包括作为其重要成分的离子液体，并将其浸渍到整个 SEM 或 TEM 样品中，或涂抹到 SEM 或 TEM 样品的观察表面上，以至少在样品的观察表面上赋予导电性。根据本发明，只需在样品上浸渍或涂覆离子液体，就能释放样品表面积累的电荷，从而轻松解决电荷积累问题。此外，即使将浸渍或涂覆离子液体的样品置于真空中，离子液体也不会从样品中蒸发，因此可以观察到生物样品的原始形状。
• DHAENENS, M.;LACOMBE, L.;LEHN, J. -M.;VIGNERON, J. -P., J. CHEM. SOC. CHEM. COMMUN., 1984, N 16, 1097-1099
  作者：DHAENENS, M.、LACOMBE, L.、LEHN, J. -M.、VIGNERON, J. -P.

  DOI：——

  日期：——