4-Octyl-benzoic acid hydrazide | 64327-92-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Octyl-benzoic acid hydrazide
• 英文别名: 4-Octylbenzohydrazide
• CAS: 64327-92-0
• 化学式: C₁₅H₂₄N₂O
• 分子量: 248.368
• InChiKey: PNHAAHOEQSGFFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Octyl-benzoic acid hydrazide 在 吡啶 、 phosphorous (V) sulfide 作用下， 生成
  参考文献：
  名称：

  Sugita, Shin-Ichi; Toda, Susumu; Teraji, Tsutomu, Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1993, vol. 237, p. 33 - 38

  摘要：

  DOI：
• 作为产物：
  描述：

  4-正辛基苯甲酸 在 硫酸 、 hydrazine hydrate 作用下， 以 甲醇 为溶剂， 反应 4.5h， 生成 4-Octyl-benzoic acid hydrazide
  参考文献：
  名称：

  Investigating the structure-activity relationships of N’ -[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds

  摘要：

  Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected chronic tropical infection endemic in Latin America. New and effective treatments are urgently needed because the two available drugs - benznidazole (BZD) and nifurtimox (NFX) - have limited curative power in the chronic phase of the disease. We have previously reported the design and synthesis of N'-[(5-nitrofuran-2-yl) methylene] substituted hydrazides that showed high trypanocidal activity against axenic epimastigote forms of three T cruzi strains. Here we show that these compounds are also active against a BZD- and NFX-resistant strain. Herein, multivariate approaches (hierarchical cluster analysis and principal component analysis) were applied to a set of thirty-six formerly characterized compounds. Based on the findings from exploratory data analysis, novel compounds were designed and synthesized. These compounds showed two-to three-fold higher trypanocidal activity against epimastigote forms than the previous set and were 25-30-fold more active than BZD. Their activity was also evaluated against intracellular amastigotes by high content screening (HCS). The most active compounds (BSF-38 to BSF-40) showed a selective index (SI') greater than 200, in contrast to the SI' values of reference drugs (NFX, 16.45; BZD, > 3), and a 70-fold greater activity than BZD. These findings indicate that nitrofuran compounds designed based on the activity against epimastigote forms show promising trypanocidal activity against intracellular amastigotes, which correspond to the predominant parasite stage in the chronic phase of Chagas disease. (C) 2017 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2017.12.011

文献信息

• Electron transport agents for organic electronic devices
  申请人：3M Innovative Properties Company

  公开号：US20040214036A1

  公开（公告）日：2004-10-28

  Compounds and compositions are provided that can be used as electron transport agents in organic electronic devices such as organic electroluminescent devices. The compounds are non-polymeric and have an aromatic core conjugated to end capping groups. The aromatic core contains a phenylene group arylene or naphthalene group arylene having a pendant heteroaryl group that includes a —C═N— unit.

  提供了可用作有机电子器件（如有机电致发光器件）中电子传输剂的化合物和组合物。这些化合物不是聚合物，具有芳香性核心，与端基团共轭。芳香性核心包含一个苯基团芳基或萘基团芳基，具有包括一个—C═N—单元的侧链杂环基团。
• ELECTROACTIVE POLYMERS
  申请人：Roberts R. Ralph

  公开号：US20060155106A1

  公开（公告）日：2006-07-13

  Electroactive polymeric arylenes and intermediates useful for making such polymers are disclosed. The present invention also provides electroactive compositions comprising the electroactive polymeric arylenes, organic electronic devices which comprise these polymers and compositions, and methods of fabricating these devices.

  本发明公开了用于制备电活性聚合物芳基化合物和中间体。本发明还提供了包括所述电活性聚合物芳基化合物的电活性组合物，包括这些聚合物和组合物的有机电子器件，以及制造这些器件的方法。
• Organic electroluminescent compositions
  申请人：——

  公开号：US20040062947A1

  公开（公告）日：2004-04-01

  Organic electroluminescent compositions comprise (a) a charge transport matrix comprising at least one electron transport material; (b) at least one non-polymeric emissive dopant; and (c) at least one tertiary aromatic amine selected from the group consisting of (1) tertiary aromatic amines wherein at least one of the organic groups comprises a substituted phenyl group having an electron-donating substituent in the para-position or two independently selected electron-donating substituents in the meta-positions, (2) tertiary aromatic amines wherein at least two of the organic groups each comprise an independently selected substituted biphenyl or substituted fluorenyl group having an electron-donating substituent in the para-position of its terminal phenyl ring, and (3) tertiary aromatic amines wherein at least one of the organic groups comprises a fused polyaromatic group and at least one other organic group comprises a substituted biphenyl or substituted fluorenyl group having an electron-donating substituent in the para-position of its terminal phenyl ring.

  有机电致发光组分包括（a）至少包括一种电子传输材料的电荷传输基质；（b）至少一种非聚合发射掺杂剂；以及（c）至少一种从以下组中选择的三级芳香胺：（1）三级芳香胺，其中至少一个有机基团包括一个带有电子供体取代基的取代苯基在对位，或者两个独立选择的电子供体取代基在间位；（2）三级芳香胺，其中至少两个有机基团各自包括一个独立选择的带有电子供体取代基的取代联苯或取代芴基在其末端苯环的对位；以及（3）三级芳香胺，其中至少一个有机基团包括一个融合的多芳香基团，至少另一个有机基团包括一个独立选择的带有电子供体取代基的取代联苯或取代芴基在其末端苯环的对位。
• Electroactive polymers
  申请人：3M Innovative Properties Company

  公开号：US20040062930A1

  公开（公告）日：2004-04-01

  Electroactive polymeric arylenes and intermediates useful for making such polymers are disclosed. The present invention also provides electroactive compositions comprising the electroactive polymeric arylenes, organic electronic devices which comprise these polymers and compositions, and methods of fabricating these devices.

  本发明揭示了用于制备电活性聚芳烃及中间体的方法。本发明还提供了包含电活性聚芳烃的电活性组合物，包括这些聚合物和组合物的有机电子器件，以及制造这些器件的方法。
• ELECTRON TRANSPORT AGENTS FOR ORGANIC ELECTRONIC DEVICES
  申请人：Bentsen G. James

  公开号：US20080026135A1

  公开（公告）日：2008-01-31

  Compounds and compositions are provided that can be used as electron transport agents in organic electronic devices such as organic electroluminescent devices. The compounds are non-polymeric and have an aromatic core conjugated to end capping groups. The aromatic core contains an arylene group having a pendant heteroaryl group that includes a —C═N— unit.

  本发明提供了可用作有机电子器件(如有机电致发光器件)中电子传输剂的化合物和组合物。这些化合物是非聚合物，具有与末端端盖基团共轭的芳香核心。该芳香核心包含一个含有一个侧链杂环基团的芳基烃基，其中该侧链杂环基团包括一个—C═N—基团。