3H-萘并[1,2-d]咪唑-2-硫醇 | 34108-95-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 3H-萘并[1,2-d]咪唑-2-硫醇
• 英文名称: 1,3-dihydro-naphtho[1,2-d]imidazole-2-thione
• 英文别名: 3H-Naphtho[1,2-d]imidazole-2-thiol；1,3-dihydrobenzo[e]benzimidazole-2-thione
• CAS: 34108-95-7
• 化学式: C₁₁H₈N₂S
• 分子量: 200.264
• InChiKey: BXYPGICASMVMLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.2
• 氢给体数：
  2
• 氢受体数：
  1

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  3H-萘并[1,2-d]咪唑-2-硫醇 在 盐酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 8-ethoxy-8,9-dihydro-naphtho[1',2':4,5]imidazo[2,1-b]thiazole
  参考文献：
  名称：

  Investigations in the imidazole series

  摘要：

  DOI：

  10.1007/bf00477398
• 作为产物：
  描述：

  4-氯-2-硝基-1-萘胺 在 palladium 10% on activated carbon 、 氢气 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 3H-萘并[1,2-d]咪唑-2-硫醇
  参考文献：
  名称：

  Synthesis and biological activity of splitomicin analogs targeted at human NAD+-dependent histone deacetylases (sirtuins)

  摘要：

  Small molecules interfering with posttranslational modification of histones are of interest as tools to study epigenetic regulation of gene transcription. Specifically, drugs that interfere with histone deacetylation could be useful to induce differentiation, growth arrest as well as apoptotic cell death in tumor cells. One class of histone deacetylases is known as sirtuins some of which (Saccharomyces cerevisiae Sir2) are for example inhibited by the lactone splitomicin leading to telomeric silencing in yeast. However, splitomicin is only a micromolar inhibitor of yeast Sir2 and does not inhibit human subtypes and the lactone is prone to hydrolytic ring opening. In preliminary SAR-studies, splitomicin analogs lacking this hydrolytically labile ring were described as inactive while the naphthalene moiety could successfully be replaced by smaller aromatic rings in a fragment-like dihydrocoumarin. Here we report the synthesis and biological activity of a series of hydrolytically stable analogs with activity against human SIRT1 and 2. These comparatively small compounds characterized by high ligand efficiency are used as a starting point toward the development of specific inhibitors of histone deacetylases from the class of sirtuins. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.01.026

文献信息

• SUBSTITUTED ACRIDINE DERIVATIVES AND THEIR USE
  申请人：Hitachi Chemical Co., Ltd.

  公开号：EP0305545A1

  公开（公告）日：1989-03-08

  Substituted acridine derivatives represented by general formula (I) (wherein R,, R2, R3, R4, R5, R6, R7, and Ra each independently represents a hydrogen atom, an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group, a halogen atom or an alkoxy group, and Z1 represents a six-membered heterocyclic aromatic group containing one or two nitrogen atoms in the ring and optionally having a 1 ~ 8C alkyl substituent or a quinolyl group) and a photopolymerizable composition containing 0.01 to 10 parts by weight of said derivative, 100 parts by weight of a photopolymerizable compound having a boiling point of 100°C or above under ordinary pressure and having at least one ethylenically unsaturated group, and 0 to 400 parts by weight of a thermoplastic organic polymer are disclosed.

  通式(I)代表的取代吖啶衍生物 (其中 R、、R2、R3、R4、R5、R6、R7 和 Ra 各自独立地代表氢原子、烷基、取代的烷基、芳基、取代的芳基、卤素原子或烷氧基，Z1 代表在环中含有一个或两个氮原子的六元杂环芳基，并可选择地具有 1 ~ 8C 烷基取代基或醌基)和一种可光聚合的组合物，该组合物含有 0.本发明公开了一种可光聚合的组合物，该组合物含有0.01至10份重量的所述衍生物、100份重量的在常压下沸点为100°C或以上并具有至少一个乙烯不饱和基团的可光聚合化合物，以及0至400份重量的热塑性有机聚合物。
• Acridine compound and photopolymerizable composition using the same
  申请人：Hitachi Chemical Co., Ltd.

  公开号：EP0360443A1

  公开（公告）日：1990-03-28

  Acridine compounds of formula (I) wherein R₁ is a divalent hydrocarbon group having 2 to 20 carbon atoms or a groupR₂O)nR₂- in which each R₂ is alkylene of 2 to 4 carbon atoms and n is an integer of 1 to 10 and have high light sensitivity and are suitable as a photopolymerisable initiator.

  式(I)的吖啶化合物 其中 R₁ 是具有 2 至 20 个碳原子的二价烃基或基团R₂O)nR₂-，其中每个 R₂ 是具有 2 至 4 个碳原子的亚烷基，n 是 1 至 10 的整数，具有高光敏感性，适合用作光聚合引发剂。
• Photopolymerizable composition for a color filter
  申请人：Mitsubishi Chemical Corporation

  公开号：EP0723167A2

  公开（公告）日：1996-07-24

  A photopolymerizable composition for a color filter, which comprises a compound having at least one ethylenically unsaturated double bond, a photopolymerization initiator, and a red, green or blue colorant and which, when formed into a coating film having a dried film thickness of at most 1 µm, has an optical density of at least 1.1.

  一种用于彩色滤光片的可光聚合组合物，它包含一种至少具有一个乙烯不饱和双键的化合物、一种光聚合引发剂和一种红色、绿色或蓝色着色剂，当形成干膜厚度不超过 1 微米的涂膜时，其光密度至少为 1.1。
• Flame retarded polymers
  申请人：CLARIANT FINANCE (BVI) LIMITED

  公开号：US20010036982A1

  公开（公告）日：2001-11-01

  The present invention relates to the use of phosphorus compounds of the formula (I) or (II) 1 as flame retardants for fibers or films of polyacrylonitrile, its copolymers or polymer blends thereof. X and R are preferably chloro, R1 and R2 are preferably methyl, and n is preferably 0-5.

  本发明涉及式 (I) 或 (II) 磷化合物的用途 1 作为聚丙烯腈、其共聚物或其聚合物混合物的纤维或薄膜的阻燃剂。X和R最好是氯，R1和R2最好是甲基，n最好是0-5。
• Ghosh, Journal of the Indian Chemical Society, 1933, vol. 10, p. 583,588
  作者：Ghosh

  DOI：——

  日期：——