Desmethyl-chlordimeform | 67346-15-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Desmethyl-chlordimeform
• 英文别名: N-(2,4-Dichlorophenyl)-N'-methylmethanimidamide
• CAS: 67346-15-0
• 化学式: C₈H₈Cl₂N₂
• 分子量: 203.071
• InChiKey: NLLSDZFMWQHOJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-methyl-N-formylaminosulfenyl chloride 、 Desmethyl-chlordimeform 在 吡啶 作用下， 生成 N-((N'-(2,4-dichlorophenyl)-N-methylformimidamido)thio)-N-methylformamide
  参考文献：
  名称：

  CH604500

  摘要：

  公开号：
• 作为产物：
  描述：

  盐酸甲胺 、 2,4-二氯苯胺 、 原甲酸三乙酯 以 乙醇 为溶剂， 反应 0.33h， 以90%的产率得到Desmethyl-chlordimeform
  参考文献：
  名称：

  Arylformamidines with antinociceptive properties

  摘要：

  A series of formamidines structurally related to clonidine were synthesized and investigated as potential nonopiate analgesics. Several of these compounds showed potent analgesic activity (ED50 on HCl writhing less than 1.0 mg/kg) with low potential for hypotensive effects. A qualitative description of the structure-activity relationship of this series reveals that the 2,4- and 2,6-dimethylphenyl compounds are more potent analgesics than are the corresponding dichlorophenyl compounds.

  DOI：

  10.1021/jm00117a023

文献信息

• FR2262030
  申请人：——

  公开号：——

  公开（公告）日：——
• GALL, M.;MCCALL, J. M.;TENBRINK, R. E.;VON, VOIGTLANDER P. F.;MOHRLAND, J+, J. MED. CHEM., 31,(1988) N 9, C. 1816-1820
  作者：GALL, M.、MCCALL, J. M.、TENBRINK, R. E.、VON, VOIGTLANDER P. F.、MOHRLAND, J+

  DOI：——

  日期：——
• US4413013A
  申请人：——

  公开号：US4413013A

  公开（公告）日：1983-11-01
• Arylformamidines with antinociceptive properties
  作者：M. Gall、J. M. McCall、R. E. TenBrink、P. F. VonVoigtlander、J. S. Mohrland

  DOI：10.1021/jm00117a023

  日期：1988.9

  A series of formamidines structurally related to clonidine were synthesized and investigated as potential nonopiate analgesics. Several of these compounds showed potent analgesic activity (ED50 on HCl writhing less than 1.0 mg/kg) with low potential for hypotensive effects. A qualitative description of the structure-activity relationship of this series reveals that the 2,4- and 2,6-dimethylphenyl compounds are more potent analgesics than are the corresponding dichlorophenyl compounds.
• CH604500
  申请人：——

  公开号：——

  公开（公告）日：——