N-(2-{[7-(N,N-dimethylaminosulfonyl)-2,1,3-benzothiadiazol-4-yl](methyl)amino}ethyl)-N-methylacrylamide | 1402567-57-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-{[7-(N,N-dimethylaminosulfonyl)-2,1,3-benzothiadiazol-4-yl](methyl)amino}ethyl)-N-methylacrylamide
• 英文别名: N-(2-{[7-(N,N-dimethylaminosulfonyl)-2,1,3-benzothiadiazol-4-yl]-(methyl)amino}ethyl)-N-methylacrylamide；N-[2-[[4-(dimethylsulfamoyl)-2,1,3-benzothiadiazol-7-yl]-methylamino]ethyl]-N-methylprop-2-enamide
• CAS: 1402567-57-0
• 化学式: C₁₅H₂₁N₅O₃S₂
• 分子量: 383.495
• InChiKey: LLEOJHUPHKTRKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  123
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-氯-2,1,3-苯并噻二唑 在 氯磺酸 、 三乙胺 作用下， 以 二氯甲烷 、 水 、 乙腈 为溶剂， 反应 6.5h， 生成 N-(2-{[7-(N,N-dimethylaminosulfonyl)-2,1,3-benzothiadiazol-4-yl](methyl)amino}ethyl)-N-methylacrylamide
  参考文献：
  名称：

  环境敏感的荧光团，其具有苯并噻二唑和苯并硒二唑结构作为荧光聚合物温度计的候选组分

  摘要：

  的环境敏感的荧光团可以改变它的最大发射波长（λ EM），荧光量子产率（Φ ˚F），和荧光寿命，响应于周围环境中。我们开发了两种新的分子内电荷转移型环境敏感荧光团DBThD-IA和DBSeD-IA，其中成熟的2,1,3-苯并恶二唑环境敏感荧光团DBD-IA的氧原子分别被硫和硒原子取代。DBThD-IA是在高荧光ñ -己烷（Φ ˚F = 0.81，λ EM = 537纳米）在449纳米激发的，但几乎是无荧光的水（Φ ˚F = 0.037，λ EM = 616纳米），类似地DBD-IA（Φ ˚F = 0.91，λ EM =在520nm处Ñ己烷; Φ ˚F = 0.027，λ EM =在水中的616纳米）。在荧光性质类似的变型也为DBSeD-IA（观察Φ ˚F = 0.24，λ EM = 591纳米Ñ己烷; Φ ˚F = 0.0046，λ EM＝ 672nm在水中）。对溶剂对这些荧光团的荧光特性的

  DOI：

  10.1002/chem.201200597

文献信息

• INTRACELLULAR DELIVERY VEHICLE
  申请人：KIRIN KABUSHIKI KAISHA

  公开号：US20190137503A1

  公开（公告）日：2019-05-09

  An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.

  一个表面覆盖正电荷的细胞内传递载体，一个所需成分或化合物装载在细胞内传递载体中的细胞内传递复合物，包括细胞内传递复合物的温度敏感探针，以及通过温度敏感探针测量细胞内温度的方法被揭示。由于其能够轻松将所需成分或化合物传递到细胞内而不抑制细胞增殖，这种细胞内传递载体非常有用。
• Temperature-sensitive fluorescent probe for introduction into cell
  申请人：KIRIN HOLDINGS KABUSHIKI KAISHA

  公开号：US10191035B2

  公开（公告）日：2019-01-29

  There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.

  提供了一种将温度敏感探针引入细胞的方法，该探针由共聚物组成，共聚物包括热致伸缩单元和荧光单元，该方法使用共聚物进一步包括阳离子单元作为温度敏感探针，该方法包括在溶剂中将共聚物与细胞混合的步骤。由于共聚物具有阳离子基团，因此无需使用特殊方法即可进入细胞，因此共聚物最好用作测量细胞内温度的荧光温度传感器。
• Intracellular delivery vehicle
  申请人：KIRIN KABUSHIKI KAISHA

  公开号：US10712346B2

  公开（公告）日：2020-07-14

  An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.

  本发明公开了一种表面被正电荷覆盖的细胞内递送载体、一种在细胞内递送载体中装载所需成分或化合物的细胞内递送复合物、一种包含细胞内递送复合物的温度敏感探针以及一种通过温度敏感探针测量细胞内温度的方法。细胞内递送载体之所以有用，是因为它能够在不抑制细胞增殖的情况下将所需的成分或化合物轻松地递送到细胞内。
• US20140342390A1
  申请人：——

  公开号：——

  公开（公告）日：——
• TEMPERATURE-SENSITIVE FLUORESCENT PROBE FOR INTRODUCTION INTO CELL
  申请人：KIRIN HOLDINGS KABUSHIKI KAISHA

  公开号：US20190113505A1

  公开（公告）日：2019-04-18

  There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.