1H-异吲哚-1,3(2H)-二酮,5-(二甲氨基)-2-羟基- | 105969-87-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 中文名称: 1H-异吲哚-1,3(2H)-二酮,5-(二甲氨基)-2-羟基-
• 英文名称: 5-(dimethylamino)-2-hydroxyisoindoline-1,3-dione
• 英文别名: 4-N,N-dimethylamino-N-hydroxypthalimide；2-hydroxy-6-(N,N-dimethylamino)-1H-isoindole-1,3-dione；Phthalimide,5-(N,N-dimethylamino)-N-hydroxy-；5-(dimethylamino)-2-hydroxyisoindole-1,3-dione
• CAS: 105969-87-7
• 化学式: C₁₀H₁₀N₂O₃
• 分子量: 206.201
• InChiKey: VRJMGPJWXCMAOB-UHFFFAOYSA-N

物化性质

• 沸点：
  439.2±47.0 °C(Predicted)
• 密度：
  1.498±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  60.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1H-异吲哚-1,3(2H)-二酮,5-(二甲氨基)-2-羟基- 、 对硝基苯磺酰氯 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 4.0h， 以63%的产率得到1H-异吲哚-1,3(2H)-二酮,5-(二甲氨基)-2-[[(4-硝基苯基)磺酰]氧代]-
  参考文献：
  名称：

  Synthesis, biological evaluation, and quantitative structure-activity relationship analysis of 2-hydroxy-1H-isoindolediones as new cytostatic agents

  摘要：

  A series of 16 derivatives of 2-hydroxy-1H-isoindole-1,3-diones was designed and synthesized as potential antitumor agents. The cytostatic activity against L1210 cell growth of these compounds was studied, and their IC50 values were found to be in the range of 10(-4) to 10(-8) M. Quantitative structure-activity relationship analysis of these compounds showed that the inhibitory effect was well correlated with the electronic and the lipophilic parameters. Derivatives having a substituent with strongly electron-donating properties at the 6-position showed enhanced inhibitory activity while compounds having an electron-withdrawing group at the same position showed lower activity.

  DOI：

  10.1021/jm00386a012
• 作为产物：
  描述：

  4-(N,N-dimethylamino)phthalic anhydride 在 吡啶 、 盐酸羟胺 作用下， 反应 15.0h， 生成 1H-异吲哚-1,3(2H)-二酮,5-(二甲氨基)-2-羟基-
  参考文献：
  名称：

  A phthalimidation protocol that follows protein defined parameters

  摘要：

  这项工作概述了第一个适用于蛋白质标记的邻苯二甲酰胺化方法，在室温和中性pH条件下在水介质中进行，无需催化剂或辅助试剂。

  DOI：

  10.1039/c4cc08503e

文献信息

• OXYGEN-ABSORBING RESIN COMPOSITION, AND MULTILAYER BODY, CONTAINER, INJECTION-MOLDED BODY, AND MEDICAL CONTAINER USING SAME
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US20150298887A1

  公开（公告）日：2015-10-22

  Provided are a novel oxygen-absorbing resin composition not responsive to a metal detector, producing no odor after absorption of oxygen and having excellent oxygen-absorbing performance, and a multilayer body, container, injection-molded article and medical container using these. Further provided are an oxygen-absorbing resin composition etc. having excellent oxygen-absorbing performance in a wide range of humidity conditions from low humidity to high humidity. The oxygen-absorbing resin composition of the present invention is an oxygen-absorbing resin composition containing a polyamide compound and a transition metal catalyst, wherein the polyamide compound has at least one constituent unit having a tetralin ring. Moreover, the multilayer body, container, injection-molded article, medical container, etc. of the present invention are obtained by using the oxygen-absorbing resin composition of the present invention.

  提供了一种新型的氧吸收树脂组合物，对金属探测器不敏感，在吸收氧气后不产生气味，具有出色的吸氧性能，以及使用这些的多层体、容器、注塑制品和医用容器。此外，还提供了一种氧吸收树脂组合物等，在从低湿度到高湿度的广泛湿度条件下具有出色的吸氧性能。本发明的氧吸收树脂组合物是一种含有聚酰胺化合物和过渡金属催化剂的氧吸收树脂组合物，其中聚酰胺化合物至少具有一个具有四氢萘环的组分单元。此外，本发明的多层体、容器、注塑制品、医用容器等是通过使用本发明的氧吸收树脂组合物获得的。
• Oxygen-Absorbing Composition And Packaging Material
  申请人：Tsuji Yoshihisa

  公开号：US20080061270A1

  公开（公告）日：2008-03-13

  An oxygen-absorbing composition of the present invention contains a gas-barrier resin as well as a salt of an unsaturated carboxylic acid and an oxygen absorption promoter that are dispersed in the gas-barrier resin A cation that composes the salt of the unsaturated carboxylic acid is a cation of at least one element selected from the group consisting of alkali metals, alkaline earth metals, and aluminum. The oxygen absorption promoter is at least one selected from the group consisting of transition metal salts, radical generators, and photocatalyst particles. The unsaturated carboxylic acid has a molecular weight of 3000 or less.

  本发明的氧气吸收组合物包含一种气体屏障树脂以及分散在气体屏障树脂中的不饱和羧酸盐和氧气吸收促进剂。组成不饱和羧酸盐的阳离子是来自于碱金属、碱土金属和铝等元素组成的至少一种元素的阳离子。氧气吸收促进剂至少包括过渡金属盐、自由基发生剂和光催化剂颗粒中的一种或多种。不饱和羧酸的分子量为3000或更低。
• OXYGEN-ABSORBING RESIN COMPOSITION AND OXYGEN-ABSORBING MOLDED ARTICLE USING SAME AND MULTILAYER BODY, CONTAINER, INJECTION-MOLDED ARTICLE AND MEDICAL CONTAINER USING THESE
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US20140308405A1

  公开（公告）日：2014-10-16

  A novel oxygen-absorbing resin composition is not responsive to a metal detector, produces no odor after absorption of oxygen and has excellent oxygen-absorbing performance, and an oxygen-absorbing molded article, and a multilayer body, container, injection-molded article and medical container. Further provided are an oxygen-absorbing resin composition etc. having excellent oxygen-absorbing performance in a wide range of humidity conditions from low to high humidity. The oxygen-absorbing resin composition is an oxygen-absorbing resin composition containing a polyester compound and a transition metal catalyst, in which the polyester compound has at least one constituent unit having a tetralin ring. Furthermore, the oxygen-absorbing molded article of the present invention is formed by molding the oxygen-absorbing resin composition into a film form or a sheet form. Moreover, the multilayer body, container, injection-molded article, medical container, etc. of the present invention are obtained by using the oxygen-absorbing resin composition of the present invention.

  一种新型的吸氧树脂组合物，不会对金属探测器产生反应，在吸收氧气后不产生异味，具有优异的吸氧性能，以及一种吸氧成型物品，多层体，容器，注塑成型物品和医疗容器。此外，还提供了一种在从低湿度到高湿度的广泛湿度条件下具有优异吸氧性能的吸氧树脂组合物等。该吸氧树脂组合物是含有聚酯化合物和过渡金属催化剂的吸氧树脂组合物，其中聚酯化合物至少具有一个四氢萘环的组分单元。此外，本发明的吸氧成型物品是通过将吸氧树脂组合物成型为膜状或片状形成的。此外，本发明的多层体，容器，注塑成型物品，医疗容器等是使用本发明的吸氧树脂组合物获得的。
• OXYGEN ABSORBING AGENT COMPOSITION
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US20150090932A1

  公开（公告）日：2015-04-02

  An oxygen absorbing agent composition including at least one type of a compound having an indane skeleton represented by the following general formula (1) and a transition metal catalyst:

  一种含有至少一种具有以下通用式（1）所表示的茚烷骨架的化合物和过渡金属催化剂的吸氧剂组合物：
• OXYGEN ABSORBENT COMPOSITION
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US20160031628A1

  公开（公告）日：2016-02-04

  The oxygen absorbent composition of the present invention at least contains a polyester oligomer containing a constitutional unit having a predetermined tetralin ring and a transition metal catalyst. It is preferable that the oxygen absorbent composition of the present invention further contains a thermoplastic resin.

  本发明的氧气吸收剂组合物至少包含一种聚酯寡聚体，其中包含具有预定四氢萘环的结构单元和过渡金属催化剂。本发明的氧气吸收剂组合物最好还包含热塑性树脂。