Androst-9(11)-en-17-one, 3-(acetyloxy)-, (3a,5a)- | 52510-48-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Androst-9(11)-en-17-one, 3-(acetyloxy)-, (3a,5a)-
• 英文别名: 3α-acetoxy-5α-androst-9(11)-en-17-one；3α-Acetoxy-5α-androst-9(11)-en-17-on；3α-Acetoxy-5α-androsten-(9(11))-on-(17)
• CAS: 52510-48-2
• 化学式: C₂₁H₃₀O₃
• 分子量: 330.467
• InChiKey: IGTOGZGFKIJBBR-FMZZOXHWSA-N

物化性质

• 沸点：
  436.0±45.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.45
• 重原子数：
  24.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  43.37
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  Androst-9(11)-en-17-one, 3-(acetyloxy)-, (3a,5a)- 在 sodium hydroxide 作用下， 生成 3α-hydroxy-5α-androst-9(11)-en-17-one
  参考文献：
  名称：

  Reconnaissance mapping and management of salt-affected soils using satellite images

  摘要：

  The Indo-Gangetic alluvial plain is subjected to large scale soil alkalization. In order to map and characterize salt-affected soils, with the aim of applying management techniques, Etah district in Uttar Pradesh, located between 26 degrees 45' to 28 degrees 02' N and 78 degrees 15' to 79 degrees 20' E was selected. Multidate, high resolution, IRS-LISS II, geocoded FCC images on 1:50 000 scale were used. Integrating visual image interpretation, physiographic analysis, ground data and laboratory analysis of soil samples, a legend for mapping salt-affected soils ( SAS) was formulated. Based on variations in physicochemical properties: nature, intensity and depth wise distribution of salts, five categories of SAS requiring specific reclamation measures were identified. Soil categories S2, S3 and S4 have a gypsum requirement ( GR) of 20, 12 and 4 t/ha(-1) respectively. Reclamation of medium to heavy textured highly alkali soils requires the addition of amendments and a rice-wheat rotation for the initial 3-4 years. Under resource constraints, pit planting of Prosopis juliflora can bring about slow but effective reclamation. The soil category S5 is slightly alkali in the substratum, needing only biological reclamation by growing salt tolerant varieties of rice and wheat crops. Soils of category S1 are saline and need management by hydrological treatments. Incorporation of village boundaries on a map showing SAS would facilitate decision taking in planning reclamation projects and accelarate management operations directly at village level.

  DOI：

  10.1080/014311600750019831
• 作为产物：
  描述：

  11β-羟基雄甾酮 在 盐酸 、 溶剂黄146 作用下， 生成 3α-hydroxy-5α-androst-9(11)-en-17-one 、 Androst-9(11)-en-17-one, 3-(acetyloxy)-, (3a,5a)-
  参考文献：
  名称：

  Reconnaissance mapping and management of salt-affected soils using satellite images

  摘要：

  The Indo-Gangetic alluvial plain is subjected to large scale soil alkalization. In order to map and characterize salt-affected soils, with the aim of applying management techniques, Etah district in Uttar Pradesh, located between 26 degrees 45' to 28 degrees 02' N and 78 degrees 15' to 79 degrees 20' E was selected. Multidate, high resolution, IRS-LISS II, geocoded FCC images on 1:50 000 scale were used. Integrating visual image interpretation, physiographic analysis, ground data and laboratory analysis of soil samples, a legend for mapping salt-affected soils ( SAS) was formulated. Based on variations in physicochemical properties: nature, intensity and depth wise distribution of salts, five categories of SAS requiring specific reclamation measures were identified. Soil categories S2, S3 and S4 have a gypsum requirement ( GR) of 20, 12 and 4 t/ha(-1) respectively. Reclamation of medium to heavy textured highly alkali soils requires the addition of amendments and a rice-wheat rotation for the initial 3-4 years. Under resource constraints, pit planting of Prosopis juliflora can bring about slow but effective reclamation. The soil category S5 is slightly alkali in the substratum, needing only biological reclamation by growing salt tolerant varieties of rice and wheat crops. Soils of category S1 are saline and need management by hydrological treatments. Incorporation of village boundaries on a map showing SAS would facilitate decision taking in planning reclamation projects and accelarate management operations directly at village level.

  DOI：

  10.1080/014311600750019831

文献信息

• 252. The structure of adreno-cortical metabolites: Δ^{9 : 11}-androstene-3 : 17-dione
  作者：C. W. Shoppee

  DOI：10.1039/jr9460001134

  日期：——
• Synthesis of a precursor for the preparation of 9α, 11α-tritiated 5α-androstane-3α,17β-diol 17-glucuronide
  作者：P.Narasimha Rao、K.M. Damodaran

  DOI：10.1016/0039-128x(84)90052-7

  日期：1984.3

  Starting from 11 beta-hydroxytestosterone, we achieved the synthesis of a strategic precursor, C-9 (11) unsaturated 5 alpha-androstane-3 alpha, 17 beta-diol 17-glucuronide (9a), for the preparation of 9 alpha,11 alpha-tritiated 5 alpha-androstane-3 alpha, 17 beta-diol 17-glucuronide. We optimized the reaction conditions for catalytic reduction employing hydrogen and subsequent base hydrolysis followed by purification on Amberlite XAD-2 resin to obtain the saturated 5 alpha-androstane-3 alpha, 17 beta-diol 17-glucuronide.