4-(Acetoxy(phenyl)methyl)phenyl acetate | 233584-35-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(Acetoxy(phenyl)methyl)phenyl acetate
• 英文别名: [4-[acetyloxy(phenyl)methyl]phenyl] acetate
• CAS: 233584-35-5
• 化学式: C₁₇H₁₆O₄
• 分子量: 284.312
• InChiKey: ARXAVYIETWNXOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-hydroxy-benzhydrol 、 乙酸酐 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以97%的产率得到4-(Acetoxy(phenyl)methyl)phenyl acetate
  参考文献：
  名称：

  Acetoxybenzhydrols as highly active and stable analogues of 1′S-1′-acetoxychavicol, a potent antiallergic principal from Alpinia galanga

  摘要：

  Through SAR studies on 1'S-1'-acetoxychavicol acetate (1) against Type I antiallergic activity by indexing release of beta-hexosaminidase, a marker of antigen-IgE-mediated degranulation in RBL-2H3 cells, more stable and potent analogue, 4-(methoxycarbonyloxyphenylmethyl) phenyl acetate (16), has been developed. The compound 16 also strongly inhibited the antigen-IgE-mediated TNF-alpha and IL-4 production. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.065

文献信息

• Acetoxybenzhydrols as highly active and stable analogues of 1′S-1′-acetoxychavicol, a potent antiallergic principal from Alpinia galanga
  作者：Tomohisa Yasuhara、Yoshiaki Manse、Takayuki Morimoto、Wang Qilong、Hisashi Matsuda、Masayuki Yoshikawa、Osamu Muraoka

  DOI：10.1016/j.bmcl.2009.04.065

  日期：2009.6

  Through SAR studies on 1'S-1'-acetoxychavicol acetate (1) against Type I antiallergic activity by indexing release of beta-hexosaminidase, a marker of antigen-IgE-mediated degranulation in RBL-2H3 cells, more stable and potent analogue, 4-(methoxycarbonyloxyphenylmethyl) phenyl acetate (16), has been developed. The compound 16 also strongly inhibited the antigen-IgE-mediated TNF-alpha and IL-4 production. (C) 2009 Elsevier Ltd. All rights reserved.