2-环己基-N-(2-环己基乙基)乙胺 | 7598-20-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-环己基-N-(2-环己基乙基)乙胺
• 英文名称: bis-(2-cyclohexyl-ethyl)-amine
• 英文别名: Bis-(2-cyclohexyl-aethyl)-amin；bis(2-cyclohexylethyl)amine；Bis-<2-cyclohexyl-aethyl>-amin；2-Cyclohexyl-N-(2-cyclohexylethyl)ethan-1-amine；2-cyclohexyl-N-(2-cyclohexylethyl)ethanamine
• CAS: 7598-20-1
• 化学式: C₁₆H₃₁N
• 分子量: 237.429
• InChiKey: FMMYWCDTBMIIPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-环己基溴乙烷 、 2-环己基-N-(2-环己基乙基)乙胺 在 sodium carbonate 作用下， 生成 tris-(2-cyclohexyl-ethyl)-amine
  参考文献：
  名称：

  Antispasmodics. II

  摘要：

  DOI：

  10.1021/ja01870a030
• 作为产物：
  描述：

  在 巯基乙酸 、 三乙胺 作用下， 以 乙酸乙酯 为溶剂， 反应 3.0h， 生成 2-环己基-N-(2-环己基乙基)乙胺
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of 1,1,3-substituted urea derivatives as potent TNF-α production inhibitors

  摘要：

  A three substituted urea derivative, SA13353 (compound 1a), exhibited potent inhibitory activity against lipopolysaccharide (LPS)-induced TNF-alpha production. We focused on the 1,1-substituted moiety (R(1) and R(2)) of SA13353 and investigated substituent effects of this moiety on LPS-induced TNF-alpha production by oral administration in rats. The synthesis of the urea derivatives was performed rapidly in a one-pot manner using a manual synthesizer. Several compounds containing hydrophobic substituents at this moiety showed more potent inhibitory activities than SA13353. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.037

文献信息

• Naphthysulfonylalkanoic acid compounds and pharmaceutical compositions
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：US05177069A1

  公开（公告）日：1993-01-05

  The present invention provides a novel class of naphthylsulfonylalkanoic acid compounds such as a structure corrresponding to the formula: ##STR1## or a pharmaceutically acceptable salt thereof. A present invention naphthylsulfonylalkanoic acid compound is useful for prevention or treatment of irritable bowel syndrome, biliary dyskinesia and acute pancreatitis.

  本发明提供了一种新型的萘磺基烷酸类化合物，例如与式子相对应的结构：##STR1## 或其药学上可接受的盐。本发明中的萘磺基烷酸类化合物可用于预防或治疗肠易激综合征、胆道运动功能障碍和急性胰腺炎。
• Naphthylsulfonylalkanoic acid compounds
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：EP0433064A1

  公开（公告）日：1991-06-19

  The present invention provides a novel class of naphthylsulfonylalkanoic acid compounds, for example a structure corresponding to the formula: or a pharmaceutically acceptable salt thereof. Naphthylsulfonylalkanoic acid compounds of the present invention are useful for prevention or treatment of irritable bowel syndrome, biliary dyskinesia and acute pancreatitis.

  本发明提供了一种新型的萘磺酰基烷基酸类化合物，例如对应于以下式子的结构：或其药学上可接受的盐。本发明的萘磺酰基烷基酸类化合物可用于预防或治疗肠易激综合征、胆道运动障碍和急性胰腺炎。
• Processes For the Preparation of Azoxystrobin Using Dabco as a Catalyst and Novel Intermediates Used in the Processes
  申请人：Whitton Alan John

  公开号：US20080214587A1

  公开（公告）日：2008-09-04

  The present invention relates, inter alia, to a process for preparing a compound of formula (I): which comprises either (a) reacting a compound of formula (II): with 2-cyanophenyl, or a salt thereof, in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane, or (b) reacting a compound of the formula (III): with a compound of the formula (IV): in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane; where W is the methyl (E)-2-(3-methoxy)acrylate group C(CO 2 CH 3 )═CHOCH 3 or the methyl 2-(3,3-dimethoxy)propanoate group C(CO 2 CH 3 )CH(OCH 3 ) 2 , or a mixture of the two groups. In addition, the present invention relates to a novel precursors of the compound of formula (I) and methods for making them.

  本发明涉及制备公式（I）化合物的方法，其中包括：（a）在1,4-二氮杂双环[2.2.2]辛存在下，将公式（II）化合物与2-氰基苯或其盐反应；或（b）在1,4-二氮杂双环[2.2.2]辛存在下，将公式（III）化合物与公式（IV）化合物反应，其中W是甲基（E）-2-（3-甲氧基）丙烯酸酯基团C（CO2CH3）═CHOCH3或甲基2-（3,3-二甲氧基）丙酸酯基团C（CO2CH3）CH（OCH3）2或两种基团的混合物。此外，本发明还涉及公式（I）化合物的新前体物及其制备方法。
• PREPARATION OF AZOXYSTROBIN
  申请人：Syngenta Limited

  公开号：EP2076498B1

  公开（公告）日：2015-02-25
• US5177069A
  申请人：——

  公开号：US5177069A

  公开（公告）日：1993-01-05