N-[(E)-thiophen-2-ylmethylideneamino]-1H-benzimidazol-2-amine | 1236278-40-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-[(E)-thiophen-2-ylmethylideneamino]-1H-benzimidazol-2-amine
• CAS: 1236278-40-2
• 化学式: C₁₂H₁₀N₄S
• 分子量: 242.304
• InChiKey: OWKAHRHEDRVZBK-MDWZMJQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  81.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-噻吩甲醛 、 2-肼基-1H-1,3-苯并咪唑 以 异丙醇 为溶剂， 反应 0.08h， 以89.45%的产率得到N-[(E)-thiophen-2-ylmethylideneamino]-1H-benzimidazol-2-amine
  参考文献：
  名称：

  Synthesis, structure, and photochemical properties of hetarylaldehydes benzimidazolyl-2-hydrazones

  摘要：

  New benzimidazolyl-2-hydrazones of 2-furaldehyde, thiophene-2-carbaldehyde and pyridine-2-carbaldehyde were synthesized and their structure was studied by H-1 NMR and X-ray analysis. Photochemical properties of these compounds and of benzothiazolyl-2-hydrazones of 2-furaldehyde, thiophene-2-carbaldehyde and pyridine-2-carbaldehyde in solutions were investigated. The process of phototransformation is determined by the nature of the aldehyde fragment of hydrazones.

  DOI：

  10.1134/s1070363210050221

文献信息

• Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity
  申请人：Lindquist Susan L.

  公开号：US20080261953A1

  公开（公告）日：2008-10-23

  Compounds and compositions are provided for treatment or amelioration of one or more symptoms of α-synuclein toxicity, α-synuclein mediated diseases or diseases in which α-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihy-dropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.

  提供了化合物和组合物，用于治疗或缓解α-突触核蛋白毒性、α-突触核蛋白介导的疾病或α-突触核蛋白纤维是疾病症状或病因的疾病中的一个或多个症状。在一种实施例中，用于组合物和方法的化合物是杂环基酰基胍、杂环基腙、二氢吡啶酮、杂环基和芳基苯乙酮以及杂环基吡唑。
• Compounds, compositions and methods of inhibiting a-synuclein toxicity
  申请人：The Whitehead Institute for Biomedical Research

  公开号：EP2433634A2

  公开（公告）日：2012-03-28

  Compounds and compositions are provided for treatment or amelioration of one or more symptoms of a-synuclein toxicity, a-synuclein mediated diseases or diseases in which a-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihydropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.

  提供的化合物和组合物用于治疗或改善a-突触核蛋白毒性、a-突触核蛋白介导的疾病或a-突触核蛋白纤维是症状或病因的疾病的一种或多种症状。在一个实施方案中，用于组合物和方法的化合物是杂芳基酰基胍、杂芳基肼、二氢吡啶酮、杂芳基和芳基苯乙烯基酮以及杂芳基吡唑。
• COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY
  申请人：WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH

  公开号：EP1802303B1

  公开（公告）日：2011-11-02
• US8440705B2
  申请人：——

  公开号：US8440705B2

  公开（公告）日：2013-05-14
• Synthesis, structure, and photochemical properties of hetarylaldehydes benzimidazolyl-2-hydrazones
  作者：I. G. Pervova、S. A. Melkozerov、P. A. Slepukhin、G. N. Lipunova、V. A. Barachevskii、I. N. Lipunov

  DOI：10.1134/s1070363210050221

  日期：2010.5

  New benzimidazolyl-2-hydrazones of 2-furaldehyde, thiophene-2-carbaldehyde and pyridine-2-carbaldehyde were synthesized and their structure was studied by H-1 NMR and X-ray analysis. Photochemical properties of these compounds and of benzothiazolyl-2-hydrazones of 2-furaldehyde, thiophene-2-carbaldehyde and pyridine-2-carbaldehyde in solutions were investigated. The process of phototransformation is determined by the nature of the aldehyde fragment of hydrazones.