2,6-二氯-4-巯基苯酚 | 42468-33-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,6-二氯-4-巯基苯酚
• 英文名称: 2,6-dichloro-4-mercapto-phenol
• 英文别名: 3,5-dichloro-4-hydroxythiophenol；3.5-Dichlor-4-oxy-1-sulfhydryl-benzol；3.5-Dichlor-4-oxy-phenylmercaptan；3.5-Dichlor-1-thio-hydrochinon；2,6-Dichlor-4-mercapto-phenol；2,6-dichloro-4-mercaptophenol；2,6-dichloro-4-sulfanylphenol
• CAS: 42468-33-7
• 化学式: C₆H₄Cl₂OS
• 分子量: 195.069
• InChiKey: LQBDPIUSHVJVQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  21.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  2,6-二氯-4-巯基苯酚 在 硫酸 作用下， 生成 1,3,6,8-tetrachloro-thianthrene-2,7-diol
  参考文献：
  名称：

  Fries; Volk, Chemische Berichte, 1909, vol. 42, p. 1175

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-二氯-4-氨基苯酚 生成 2,6-二氯-4-巯基苯酚
  参考文献：
  名称：

  Schaefer, Ted; Baleja, James D.; Penner, Glenn H., Canadian Journal of Chemistry, 1985, vol. 63, p. 2471 - 2475

  摘要：

  DOI：

文献信息

• Methods and compositions for inhibiting lipoxygenase
  申请人：G. D. Searle & Co.

  公开号：US04857558A1

  公开（公告）日：1989-08-15

  This invention encompasses a pharmaceutical composition comprising a pharmaceutical carrier and an effective lipoxygenase inhibiting amount of a compound of the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are same or different members of the group consisting of 1,1-dimethyl ethyl, halo, phenyl and substituted phenyl; Alk is straight or branched chain lower alkylene; R.sub.4 is hydrogen or lower alkyl; R.sub.3 is hydrogen or lower alkyl; or a cycloalkyl group of from 3 to 8 carbon atoms. The formulation of this invention are useful as anti-inflammatory and anti-allergy agents.

  这项发明涵盖了一种药物组合物，包括药用载体和一定量有效的抑制脂氧合酶的化合物，其化学式为：##STR1## 其中：R.sub.1和R.sub.2是1,1-二甲基乙基、卤素、苯基和取代苯基组成的同类或不同类成员；Alk是直链或支链低碳烷基；R.sub.4是氢或低碳烷基；R.sub.3是氢或低碳烷基；或者是由3至8个碳原子组成的环烷基团。这项发明的配方可用作抗炎和抗过敏药剂。
• Novel disubstituted 4-hydroxyphenylthio anilides
  申请人：G. D. Searle & Co.

  公开号：US05071876A1

  公开（公告）日：1991-12-10

  The compounds of this invention are anilides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided that n+m+p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is hydrogen or lower alkyl; and R.sub.4 is phenyl or substituted phenyl. The compounds of the present invention are useful in the treatment of inflammation, allergy and hypersensitivity reactions and other disorders of the immune system.

  本发明的化合物是酰替苯胺，其由下式表示：##STR1## 其中：R.sub.1和R.sub.2是相同或不同的卤素、苯基、取代苯基以及一个##STR2##基团，其中n、m和p是独立地从1到8的整数，只要n+m+p等于或小于10；X是硫代、亚磺酰基或磺酰基；Alk是直链或支链的低级烷基；R.sub.3是氢或低级烷基；R.sub.4是苯基或取代苯基。本发明的化合物可用于治疗炎症、过敏和超敏反应以及免疫系统等其他疾病。
• Acylaminoalkylpyridineamides as inhibitors of metastasis
  申请人：G. D. Searle & Co.

  公开号：US05030642A1

  公开（公告）日：1991-07-09

  The present invention relates to a method of inhibiting tumor metastasis in an aminal by administering to an animal in need of such treatment an acrylaminoalkylpryridineamides represented by the formula ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided n+m+p is equal to or less than 10; x is thio or sulfinyl; Alk.sub.1 is straight or branched chain lower alkylene of 1 to 6 carbon atoms, R.sub.3 is hydrogen or lower alkyl, Alk.sub.2 is straight or branched chain alkylene of 1 to 4 carbon atoms; R.sub.4 is selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl and lower alkoxy; or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit tumor metastasis.

  本发明涉及一种通过向需要此类治疗的动物投与下列式所代表的丙烯基吡啶酰胺类物质来抑制动物体内肿瘤转移的方法： 其中：R.sub.1和R.sub.2是卤素、苯基、取代苯基和一个##STR2##基团中相同或不同的成员，其中n、m和p分别是1到8的整数，但要求n+m+p小于等于10；x为硫代基或亚硫代基；Alk.sub.1为1到6个碳原子的直链或支链较低烷基，R.sub.3为氢或较低烷基，Alk.sub.2为1到4个碳原子的直链或支链烷基；R.sub.4选自氢、卤素、羟基、较低烷基和较低烷氧基的群；或其药学上可接受的盐，在有效量下，用于抑制肿瘤转移。
• Acylaminoalkylpyridines ad use in treatment of inflammation and allergy
  申请人：G. D. Searle & Co.

  公开号：US04663333A1

  公开（公告）日：1987-05-05

  The compounds of this invention are acylaminoalkylpyridines representd by the formula ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided n+m+p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk.sub.1 is straight or branched chain lower alkylene of 1 to 6 carbon atoms, R.sub.3 is lower alkyl, Alk.sub.2 is straight or branched chain alkylene of 1 to 4 carbon atoms; R.sub.4 is selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl and lower alkoxy; and the pharmaceutically acceptable salts thereof. The compounds of the present invention are useful in the treatment of inflammation, allergy and hypersensitivity reactions and other disorders of the immune system.

  本发明的化合物是由以下式表示的酰胺基烷基吡啶：其中：R.sub.1和R.sub.2是卤素、苯基、取代苯基和##STR2##基的相同或不同成员，其中n、m和p分别是1到8的整数，且n+m+p等于或小于10；X是硫、亚砜基或砜基；Alk.sub.1是1到6个碳原子的直链或支链低碳烷基，R.sub.3是低碳基，Alk.sub.2是1到4个碳原子的直链或支链烷基；R.sub.4选自氢、卤素、羟基、低烷基和低烷氧基的组成成员；以及其药用盐。本发明的化合物在治疗炎症、过敏和过敏反应以及其他免疫系统疾病方面具有用途。
• Carbamoylimidazole derivatives and fungicidal use thereof
  申请人：Nihon Tokushu Noyaku Seizo K.K.

  公开号：US04609669A1

  公开（公告）日：1986-09-02

  Novel carbamoylimidazole derivatives of the formula (I) ##STR1## in which R.sup.1 represents lower alkyl, lower alkoxy-lower alkyl or cycloalkyl having 3 to 8 carbon atoms, R.sup.2 represents fluoro-substituted lower alkyl, X represents oxygen or sulfur, Y represents halogen or lower alkyl, m represents the numbers 0, 1 or 2, and n represents the numbers 2, 3, 4, 5 or 6, and the use of the new compounds as agricultural and horticultural fungicides.

  新型的卡巴莫基咪唑衍生物的化学式（I）为：##STR1## 其中R.sup.1代表低碳基，低碳氧基-低碳基或环烷基，碳数为3到8，R.sup.2代表氟代低碳基，X代表氧或硫，Y代表卤素或低碳基，m代表数字0、1或2，n代表数字2、3、4、5或6，以及新化合物作为农业和园艺杀菌剂的用途。