4-(Dimethylamino)fluorene | 92013-89-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 4-(Dimethylamino)fluorene
• 英文别名: N.N-Dimethyl-fluoren-amin-(4)；N.N-Dimethyl-fluoren-amin-(1)；N,N-dimethyl-9H-fluoren-4-amine
• CAS: 92013-89-3
• 化学式: C₁₅H₁₅N
• 分子量: 209.291
• InChiKey: AUXNVAUAYSEDCH-UHFFFAOYSA-N

物化性质

• 熔点：
  37 °C(Solv: ligroine (8032-32-4))
• 沸点：
  369.0±21.0 °C(Predicted)
• 密度：
  1.123±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  磷酸三甲酯 、 4-乙酰氨基芴 生成 4-(Dimethylamino)fluorene
  参考文献：
  名称：

  Ionization Constants of Derivatives of Fluorene and Other Polycyclic Compounds²

  摘要：

  DOI：

  10.1021/jo01063a006

文献信息

• Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease
  申请人：Jin Lee-Way

  公开号：US20070254889A1

  公开（公告）日：2007-11-01

  The present invention is directed to pharmaceutical compositions comprising one or more compounds of Formulae I, II, III, IV, V, VI, VII, VIII, IX and X, or pharmaceutically acceptable salts thereof and excipients. The present invention provides a method of inhibiting β-amyloid plaque aggregation, the method comprising introducing into a mammal an aggregation-inhibiting amount of a compound of Formula I, II, III, IV, V, VI, VII, VIII, IX or X or a pharmaceutically acceptable salt, ester, amide or prodrug thereof. By inhibiting amyloid aggregation, this method is capable of rescuing cells that otherwise would be susceptible or further damaged by amyloidosis.

  本发明涉及一种制药组合物，包括式I、II、III、IV、V、VI、VII、VIII、IX和X中的一个或多个化合物，或其药学上可接受的盐和辅料。本发明提供了一种抑制β-淀粉样斑块聚集的方法，该方法包括向哺乳动物中引入式I、II、III、IV、V、VI、VII、VIII、IX或X中的一种化合物或其药学上可接受的盐、酯、酰胺或前药的抑制聚集量。通过抑制淀粉样聚集，该方法能够挽救那些本来易受淀粉样蛋白病损伤的细胞。
• Biphenyls and fluorenes as imaging agents in alzheimer's disease
  申请人：Kung F. Hank

  公开号：US20050271584A1

  公开（公告）日：2005-12-08

  This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.

  本发明涉及成像淀粉样沉积物的方法、标记化合物及制备标记化合物的方法。本发明还涉及抑制淀粉样蛋白聚集形成淀粉样沉积物的化合物及制备化合物的方法，以及向淀粉样沉积物传递治疗剂的方法。
• Metal Complexes and Electroluminescent Devices Comprising These Metal Complexes
  申请人：MERCK PATENT GMBH

  公开号：US20180066000A1

  公开（公告）日：2018-03-08

  The present invention relates to metal complexes having a metal atom of groups 13 to 15 and at least one ligand, where the ligand comprises at least one anionic coordination group having at least one oxygen and/or nitrogen atom via which the metal atom is coordinated, and the ligand comprises at least one triarylamine group, to processes for preparation thereof and to the use thereof in electronic devices, especially in organic electroluminescent devices, called OLEDs (OLED=organic light emitting diode). The present invention also further relates to organic electroluminescent devices comprising these metal complexes.

  本发明涉及具有13至15组金属原子和至少一个配体的金属配合物，其中配体包括至少一个带有至少一个氧和/或氮原子的阴离子配位基，通过该基金属原子被配位，并且配体包括至少一个三芳胺基团，以及其制备方法和在电子器件中的使用，特别是在有机电致发光器件中，称为OLED（OLED = 有机发光二极管）。本发明还涉及包含这些金属配合物的有机电致发光器件。
• Olefin polymerisation catalysts and processes for producing olefin polymers
  申请人：TOSOH CORPORATION

  公开号：EP0849292A1

  公开（公告）日：1998-06-24

  Catalysts for olefin polymerization which consist essentially of a transition metal compound, a modified clay compound and an organic aluminum compound, wherein the modified clay compound comprises a reaction product of a clay mineral and a proton acid salt of a specific amine compound, as well as a method of polymerizing olefins using such catalysts. It is possible thereby to obtain olefin polymers with high productivity and low ash content.

  烯烃聚合催化剂，主要由过渡金属化合物、改性粘土化合物和有机铝化合物组成，其中改性粘土化合物包括粘土矿物和特定胺化合物的质子酸盐的反应产物，以及使用这种催化剂聚合烯烃的方法。由此可以获得生产率高、灰分含量低的烯烃聚合物。
• Catalyst for olefin polymer production and process for olefin polymer production employing the catalyst
  申请人：TOSOH CORPORATION

  公开号：EP0942006A2

  公开（公告）日：1999-09-15

  A novel catalyst for olefin polymerization is provided which comprises [A] a metallocene compound containing a transition metal selected from Groups 3, 4, 5, and 6 of Periodic Table, [B] a reaction product of topotactic reduction by electron transfer, and [C] an organoaluminum compound. The catalyst may contain additionally [D] an organoalkaline earth metal compound or an organozinc compound. This catalyst has high catalytic activity for olefin polymerization without employing an expensive catalyst component.

  提供了一种用于烯烃聚合的新型催化剂，它包括[A]一种含有选自元素周期表第 3、4、5 和 6 族的过渡金属的茂金属化合物，[B]一种通过电子转移进行拓扑还原的反应产物，以及[C]一种有机铝化合物。催化剂中还可添加 [D] 有机碱土金属化合物或有机锌化合物。这种催化剂对烯烃聚合具有很高的催化活性，而无需使用昂贵的催化剂组分。