3-phenyl-5-hydroxyisoxazole | 23253-51-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-phenyl-5-hydroxyisoxazole
• 英文别名: 5-Hydroxy-3-phenyl-isoxazol；3-phenyl-2H-isoxazol-5-one；3-phenyl-5-hydroxy-2-isoxazole
• CAS: 23253-51-2
• 化学式: C₉H₇NO₂
• mdl: MFCD02380080
• 分子量: 161.16
• InChiKey: LTZXORXEHPKYKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.16
• 重原子数：
  12.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.26
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  重氮苯磺酸 、 3-phenyl-5-hydroxyisoxazole 在 氢氧化钾 作用下， 以 水 为溶剂， 反应 0.17h， 以72%的产率得到1-(5-hydroxy-3-phenyl-4-isoxazolylazo)-4-benzenesulphonic acid
  参考文献：
  名称：

  Rao, Ch. Nagarjun; Rajanna, K. C.; Devi, Y. Uma, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1988, vol. 27, # 10, p. 893 - 897

  摘要：

  DOI：

文献信息

• OPTICAL RECORDING MEDIUM AND AZO METAL CHELATE COMPOUND
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1997856A1

  公开（公告）日：2008-12-03

  The present invention is to provide an optical recording medium which is capable of performing good recording and reproducing by using a laser having a wavelength of 300 to 900 nm, a novel azo metal chelate compound, and a novel azo compound. Furthermore, the present invention is to provide an optical recording medium having an azo metal chelate compound in a recording layer.

  本发明提供了一种光记录介质，通过使用波长为300至900纳米的激光、一种新型偶氮金属螯合物和一种新型偶氮化合物，能够进行良好的记录和再现。此外，本发明提供了一种在记录层中含有偶氮金属螯合物的光记录介质。
• Transition-Metal Charge Transport Materials, Methods Of Fabrication Thereof, And Methods Of Use Thereof
  申请人：Seth Marder

  公开号：US20080121870A1

  公开（公告）日：2008-05-29

  Briefly described, embodiments of this disclosure include transition-metal charge-transport materials, methods of forming transition-metal charge-transport materials, and methods of using the transition-metal charge-transport materials.

  简要描述，本公开的实施例包括过渡金属电荷传输材料，形成过渡金属电荷传输材料的方法以及使用过渡金属电荷传输材料的方法。
• Quinazoline derivative and application thereof
  申请人：Lu Canzhong

  公开号：US09193718B2

  公开（公告）日：2015-11-24

  This invention provides a class of quinazoline compounds, as represented by formula (I), and their pharmaceutically acceptable salts, wherein: each of R1 and R2 independently, is selected from H, C1-C6 alkoxy, halo-C1-C6 alkoxy, C1-C6-alkoxy-C1-C6 alkoxy, C3-C8 cycloalkoxy, C3-C8 heterocycloalkoxy containing at least one of heteroatoms selected from N, O, S; Z is —NR4—, C(R5)2, S or —O—, wherein R4 is H or C1-C3 alkyl, R5 is the same or different, selected from H or C1-C3 alkyl; R3 is selected from H, halogen, C1-C6 alkyl, C1-C6 alkoxy or halo-C1-C6 alkyl; n is an integer from 0 to 5. This invention also provides methods of preparation and medical uses of the compounds of formula (I) and their pharmaceutically acceptable salts. These compounds have the activity of inhibiting EGFR-TK, and can be used as drugs for the treatment of protein tyrosine kinase related diseases such as tumors, cancers, etc.

  本发明提供了一类喹唑啉化合物，如式（I）所示，以及它们的药学上可接受的盐，其中：R1和R2中的每一个独立地选择自H、C1-C6烷氧基、卤代C1-C6烷氧基、C1-C6-烷氧基-C1-C6烷氧基、C3-C8环烷氧基、含有至少一个从N、O、S中选择的杂原子的C3-C8杂环烷氧基；Z是—NR4—、C（R5）2、S或—O—，其中R4是H或C1-C3烷基，R5相同或不同，选择自H或C1-C3烷基；R3选择自H、卤素、C1-C6烷基、C1-C6烷氧基或卤代C1-C6烷基；n是0到5的整数。本发明还提供了制备方法和化合物的医药用途。这些化合物具有抑制EGFR-TK的活性，可用作治疗蛋白酪氨酸激酶相关疾病如肿瘤、癌症等的药物。
• Alpha-heteroaryloxymethyl ketones as interleukin-1beta converting enzyme inhibitors
  申请人：STERLING WINTHROP INC.

  公开号：EP0644198A1

  公开（公告）日：1995-03-22

  Disclosed are compounds, compositions and methods for inhibiting interleukin - 1β protease activity, the compounds having the formula (I) defined herein.

  公开了用于抑制白细胞介素-1β蛋白酶活性的化合物、组合物和方法，这些化合物具有本文定义的式 (I)。
• Squarylium compounds as filters for electronic display device
  申请人：Kyowa Yuka Co., Ltd.

  公开号：EP1335215A1

  公开（公告）日：2003-08-13

  The present invention provides filters for an electronic display device comprising a squarylium compound represented by the general formula (I): wherein X represents a nitrogen atom or an oxygen atom; Q represents a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom; and R1, R2, R3, R4, R5, R6 and m are as defined in the specification. The filters for an electronic display device of the present invention can selectively shield the light having such a wavelength that reduces the color purity, and thereby can provide clear images.

  本发明提供了用于电子显示设备的滤光片，该滤光片由通式(I)代表的鳞片状化合物组成： 其中 X 代表氮原子或氧原子；Q 代表碳原子、氮原子、氧原子或硫原子；以及 R1、R2、R3、R4、R5、R6 和 m 如说明书中所定义。本发明用于电子显示设备的滤光片可以选择性地屏蔽具有降低色纯度的波长的光，从而提供清晰的图像。