β.2-Dimethyl-phenaethylamin | 5266-88-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: β.2-Dimethyl-phenaethylamin
• 英文别名: 2-o-tolyl-propylamine；2-(2-Methylphenyl)propan-1-amine
• CAS: 5266-88-6
• 化学式: C₁₀H₁₅N
• 分子量: 149.236
• InChiKey: QVOBWGRFQSLGEN-UHFFFAOYSA-N

物化性质

• 沸点：
  117-120 °C(Press: 15 Torr)
• 密度：
  0.935±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  甲酸 、 β.2-Dimethyl-phenaethylamin 生成 4,5-dimethyl-isoquinoline
  参考文献：
  名称：

  Hormonal control of a gene encoding a putative PDR5-like ABC transporter in periwinkle

  摘要：

  ATP binding cassette (ABC) transporters retain increasing attention since their implication in multidrug resistance has been demonstrated in several prokaryotic and eukaryotic cells. Many ARC proteins are known in various organisms but only few in higher plants. We report here on the characterization of a partial 955 bp clone (Cr-ABC1) isolated from a Catharanthus roseus cDNA library, which shows high homology (65% identity) with the TUR2 cDNA previously isolated from the water lens Spirodela polyrrhiza. Accumulation of Cr-ABC1 transcripts in cultured C. roseus cells was enhanced by cytokinin or methyl jasmonate addition to, or auxin suppression from the culture medium. In whole plants, the gene was mainly expressed in flowers.

  DOI：

  10.1080/12538078.2000.10515842
• 作为产物：
  描述：

  2-(邻甲苯基)丙腈 在 镍 作用下， 生成 β.2-Dimethyl-phenaethylamin
  参考文献：
  名称：

  Hormonal control of a gene encoding a putative PDR5-like ABC transporter in periwinkle

  摘要：

  ATP binding cassette (ABC) transporters retain increasing attention since their implication in multidrug resistance has been demonstrated in several prokaryotic and eukaryotic cells. Many ARC proteins are known in various organisms but only few in higher plants. We report here on the characterization of a partial 955 bp clone (Cr-ABC1) isolated from a Catharanthus roseus cDNA library, which shows high homology (65% identity) with the TUR2 cDNA previously isolated from the water lens Spirodela polyrrhiza. Accumulation of Cr-ABC1 transcripts in cultured C. roseus cells was enhanced by cytokinin or methyl jasmonate addition to, or auxin suppression from the culture medium. In whole plants, the gene was mainly expressed in flowers.

  DOI：

  10.1080/12538078.2000.10515842

文献信息

• Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors
  申请人：High Point Pharmaceuticals, LLC

  公开号：US20140371250A1

  公开（公告）日：2014-12-18

  The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.

  本发明涉及式（I）所定义的化合物、制药组合物及其在治疗由TNF-α或PDE4介导的疾病或疾病中的应用方法，包括但不限于类风湿性关节炎。
• Biocatalytic Cascade Conversion of Racemic Epoxides to ( <i>S</i> )‐2‐Arylpropionic Acids, ( <i>R</i> )‐ and ( <i>S</i> )‐2‐Arylpropyl Amines
  作者：Willy W. L. See、Xirui Li、Zhi Li

  DOI：10.1002/adsc.202201061

  日期：2023.1.10

  New types of one-pot multi-step enzymatic cascade transformation involving dynamic kinetic resolution to convert racemic substrates to chiral products in high ee and yield were developed. Unique cascade reactions of easily accessible racemic trans-β-methyl or α-methyl epoxides to produce (S)-2-arylpropionic acids, (R)- and (S)-2-arylpropyl amines were demonstrated via styrene oxide isomerase (SOI)-catalyzed

  开发了新型一锅多步酶促级联转化，涉及动态动力学拆分，以将外消旋底物转化为高ee和收率的手性产物。通过氧化苯乙烯异构酶 (SOI) 证明了容易获得的外消旋反式-β-甲基或 α-甲基环氧化物产生 ( S )-2-芳基丙酸、( R )- 和 ( S )-2-芳基丙基胺的独特级联反应-催化 Meinwald 环氧化物重排原位生成 2-芳基丙醛，随后自发消旋化，以及乙醇脱氢酶 (ADH)-催化的 ( S )-对映选择性氧化或转氨酶 (TA)-催化的 ( R )- 或 (S）-对映选择性胺化，分别。用分离的酶或全细胞生物催化剂进行的级联反应产生具有高对映选择性和产量的药学相关 ( S )-2-芳基丙酸、( R )- 和 ( S )-2-芳基丙基胺。从环氧化物原位生成醛开始的级联有效地减少了与醛不稳定性相关的副反应，并显示出广泛的底物范围。
• BORON-CONTAINING SMALL MOLECULES
  申请人：Anacor Pharmaceuticals, Inc.

  公开号：EP2164331B1

  公开（公告）日：2017-11-29
• TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS
  申请人：vTv Therapeutics LLC

  公开号：US20160296526A1

  公开（公告）日：2016-10-13

  The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to psoriasis.
• US4886785A
  申请人：——

  公开号：US4886785A

  公开（公告）日：1989-12-12