(4-cyclopropylphenyl)hydrazine | 53712-81-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-cyclopropylphenyl)hydrazine
• CAS: 53712-81-5
• 化学式: C₉H₁₂N₂
• 分子量: 148.208
• InChiKey: UCUQWSXSCAJAHO-UHFFFAOYSA-N

物化性质

• 沸点：
  292.8±19.0 °C(Predicted)
• 密度：
  1.194±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4-cyclopropylphenyl)hydrazine 在 sodium hydride 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 6.0h， 生成 5-Chloro-2-(4-cyclopropylphenyl)-4-(4-methoxyphenoxy)-3-pyridazinone
  参考文献：
  名称：

  Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)

  摘要：

  Novel smallmolecule antagonists ofNPBWR1 (GPR7) are herein reported. A high-throughput screening (HTS) of the Molecular Libraries-Small Molecule Repository library identified 5-chloro-4-(4-methoxyphenoxy)-2-(p-tolyl)pyridazin-3(2H)-one as a NPBWR1 hit antagonist with micromolar activity. Design, synthesis and structure-activity relationships study of the HTS-derived hit led to the identification of 5-chloro-2-(3,5-dimethylphenyl)-4-(4-methoxyphenoxy) pyridazin-3(2H)-one lead molecule with sub-micromolar antagonist activity at the target receptor and high selectivity against a panel of therapeutically relevant off-target proteins. This lead molecule may provide a pharmacological tool to clarify the molecular basis of the in vivo physiological function and therapeutic utility of NPBWR1 in diverse disease areas including inflammatory pain and eating disorders. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.09.074

文献信息

• [EN] PYRAZOLE DERIVATIVE COMPOUND AND USE THEREOF<br/>[FR] COMPOSÉ DÉRIVÉ DE PYRAZOLE ET SON UTILISATION
  申请人：HANMI PHARM IND CO LTD

  公开号：WO2019054766A1

  公开（公告）日：2019-03-21

  Provided is a compound represented by Formula 1 having an inhibitory activity on lysine-specific demethylase-1 (LSD1), an optical isomer, a solvate, a tautomer, or a pharmaceutically acceptable salt thereof, which is effective in preventing or treating a disease caused by abnormal activation of LSD1.

  提供的是一种由化学式1表示的化合物，具有对赖氨酸特异性去甲基化酶-1（LSD1）具有抑制活性的光学异构体、溶剂化合物、互变异构体或其药用可接受盐，可有效预防或治疗由LSD1异常活化引起的疾病。
• Pyrazole derivative compound and use thereof
  申请人：HANMI PHARM. CO., LTD.

  公开号：US11254676B2

  公开（公告）日：2022-02-22

  Provided is a compound represented by Formula 1 having an inhibitory activity on lysine-specific demethylase-1 (LSD1), an optical isomer, a solvate, a tautomer, or a pharmaceutically acceptable salt thereof, which is effective in preventing or treating a disease caused by abnormal activation of LSD1.

  本发明提供了对赖氨酸特异性去甲基化酶-1（LSD1）具有抑制活性的式 1 所代表的化合物、其光学异构体、溶剂、同系物或药学上可接受的盐，可有效预防或治疗由 LSD1 异常活化引起的疾病。
• PYRAZOLE DERIVATIVE COMPOUND AND USE THEREOF
  申请人：Hanmi Pharm. Co., Ltd.

  公开号：EP3681877A1

  公开（公告）日：2020-07-22