(8-Bromo-7-methylnaphthalen-2-yl)methanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (8-Bromo-7-methylnaphthalen-2-yl)methanol
• 英文别名: (8-bromo-7-methylnaphthalen-2-yl)methanol
• 化学式: C₁₂H₁₁BrO
• 分子量: 251.123
• InChiKey: JACVKBVPTKXSQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (8-Bromo-7-methylnaphthalen-2-yl)methanol 在 氯化亚砜 、 zinc(II) chloride 作用下， 以 1,4-二氧六环 、 水 、 乙腈 为溶剂， 反应 19.67h， 生成
  参考文献：
  名称：

  Antihyperglycemic activity of novel naphthalenylmethyl-3H-1,2,3,5-oxathiadiazole 2-oxides

  摘要：

  A series of naphthalenyl 3H-1,2,3,5-oxathiadiazole 2-oxides was prepared and tested for antihyperglycemic activity in the db/db mouse, a model for type 2 (non-insulin dependent) diabetes mellitus. Substitution at the 1-, 5-, or 8-positions of the naphthalene ring with a halogen was found to be beneficial to antihyperglycemic activity. 4-[(5-Chloronaphthalen-2-yl)methyl]-3H-1,2,3,5-oxathiadiazole 2-oxide (45), one of the most potent compounds in this series, was selected for further pharmacological evaluation.

  DOI：

  10.1021/jm00069a006
• 作为产物：
  描述：

  2-carbocy-7-methylnaphthalene 在 溴 、 二异丁基氢化铝 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 21.0h， 生成 (8-Bromo-7-methylnaphthalen-2-yl)methanol
  参考文献：
  名称：

  Antihyperglycemic activity of novel naphthalenylmethyl-3H-1,2,3,5-oxathiadiazole 2-oxides

  摘要：

  A series of naphthalenyl 3H-1,2,3,5-oxathiadiazole 2-oxides was prepared and tested for antihyperglycemic activity in the db/db mouse, a model for type 2 (non-insulin dependent) diabetes mellitus. Substitution at the 1-, 5-, or 8-positions of the naphthalene ring with a halogen was found to be beneficial to antihyperglycemic activity. 4-[(5-Chloronaphthalen-2-yl)methyl]-3H-1,2,3,5-oxathiadiazole 2-oxide (45), one of the most potent compounds in this series, was selected for further pharmacological evaluation.

  DOI：

  10.1021/jm00069a006

文献信息

• BHQ-CONJUGATES, AND RELATED COMPOUNDS, METHODS OF MAKING THE SAME, AND METHODS OF USE THEREOF
  申请人：Dore Timothy M.

  公开号：US20140155362A1

  公开（公告）日：2014-06-05

  Embodiments of the present disclosure provide for BHQ-conjugates and protected BHQ-conjugate precursor compounds, methods of making BHQ-conjugates and protected BHQ-conjugate precursor compounds, methods of using BHQ-conjugates and protected BHQ-conjugate precursor compounds, and the like.

  本公开的实施例提供了BHQ共轭物和受保护的BHQ共轭物前体化合物，制备BHQ共轭物和受保护的BHQ共轭物前体化合物的方法，使用BHQ共轭物和受保护的BHQ共轭物前体化合物的方法等。
• Antihyperglycemic activity of novel naphthalenylmethyl-3H-1,2,3,5-oxathiadiazole 2-oxides
  作者：John W. Ellingboe、Louis J. Lombardo、Thomas R. Alessi、Thomas T. Nguyen、Frieda Guzzo、Charles J. Guinosso、James Bullington、Eric N. C. Browne、Jehan F. Bagli

  DOI：10.1021/jm00069a006

  日期：1993.8

  A series of naphthalenyl 3H-1,2,3,5-oxathiadiazole 2-oxides was prepared and tested for antihyperglycemic activity in the db/db mouse, a model for type 2 (non-insulin dependent) diabetes mellitus. Substitution at the 1-, 5-, or 8-positions of the naphthalene ring with a halogen was found to be beneficial to antihyperglycemic activity. 4-[(5-Chloronaphthalen-2-yl)methyl]-3H-1,2,3,5-oxathiadiazole 2-oxide (45), one of the most potent compounds in this series, was selected for further pharmacological evaluation.