1-硝基-2-苯基胍 | 5461-83-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1-硝基-2-苯基胍
• 英文名称: 3-Nitro-1-phenyl-guanidin
• 英文别名: N-nitro-N'-phenyl-guanidine；N-Nitro-N'-phenyl-guanidin；2-Nitro-1-phenylguanidine；2-nitro-1-phenylguanidine
• CAS: 5461-83-6
• 化学式: C₇H₈N₄O₂
• 分子量: 180.166
• InChiKey: HUDUGAFSLWBJOZ-UHFFFAOYSA-N

物化性质

• 熔点：
  152-153 °C
• 沸点：
  294.6±23.0 °C(Predicted)
• 密度：
  1.40±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  96.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-硝基-2-苯基胍 在 硝酸 、 sodium nitrite 作用下， 生成 2-nitrophenylcyanamide
  参考文献：
  名称：

  潜在的抗癌药。XXXI。化学结构与1-甲基-3-硝基-1-亚硝基胍（NSC-9369）类似物对抗白血病活性的关系。

  摘要：

  DOI：

  10.1021/jm50010a005
• 作为产物：
  描述：

  1-甲基-3-硝基-1-亚硝基胍 生成 1-硝基-2-苯基胍
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Pyrimidine Derivatives
  申请人：Klebl Bert

  公开号：US20080187575A1

  公开（公告）日：2008-08-07

  The present invention relates to pyrimidine derivatives, methods for their synthesis, and the use of said pyrimidine derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of cell proliferation disorders, cancer, leukemia, erectile dysfunction, cardiovascular diseases and disorders, inflammatory diseases, transplant rejection, immunological diseases, neuroimmunological diseases, autoimmune diseases, infective diseases including opportunistic infections, prion diseases and/or neuro-degeneration. Furthermore, the present invention relates to pharmaceutical compositions containing at least one pyrimidine derivative and/or pharmaceutically acceptable salts thereof as an active ingredient together with at least one pharmaceutically acceptable carrier, excipient or diluents as well as to methods for prophylaxis and/or treatment of the above-mentioned diseases and disorders.

  本发明涉及嘧啶衍生物，其合成方法，以及所述嘧啶衍生物作为药用活性剂的用途，特别是用于预防和/或治疗细胞增殖紊乱、癌症、白血病、勃起功能障碍、心血管疾病和紊乱、炎症性疾病、移植排斥、免疫性疾病、神经免疫性疾病、自身免疫性疾病、感染性疾病包括机会性感染、朊病和/或神经退行性疾病。此外，本发明涉及含有至少一种嘧啶衍生物和/或其药用可接受盐作为活性成分的药物组合物，以及用于预防和/或治疗上述疾病和紊乱的方法。
• Compositions and methods for inhibiting arginase activity
  申请人：The Trustees of the University of Pennsylvania

  公开号：US20030036529A1

  公开（公告）日：2003-02-20

  Compositions and methods for inhibiting arginase activity, including arginase activity in a mammal, are provided. Methods of making the compositions of the invention are also provided as are methods of using the compositions therapeutically. The compositions described herein are useful for alleviating or inhibiting a variety of arinase- and NO synthase-related disorders, including heart diseae, gastrointestinal motility disorders, and penile erectile dysfunction in humans.

  本发明提供了抑制精氨酸酶活性的组合物和方法，包括哺乳动物中的精氨酸酶活性。本发明还提供了制备所述组合物的方法，以及使用所述组合物进行治疗的方法。所述组合物可用于缓解或抑制多种与精氨酸酶和NO合酶相关的疾病，包括心脏病、胃肠动力障碍和人类勃起功能障碍。
• The use of substituted nitro and cyanoguanidines for increasing crop yield
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0113070A1

  公开（公告）日：1984-07-11

  Novel substituted phenyl and benzyl nitro-guanidine and phenyl and benzyl cyanoguanidine compounds. Methods for increasing crop yield, inhibiting lodging of graminaceous crops, and inducing cytokinin-like responses in crop plants with said novel guanidine compounds and derivatives thereof, as well as methods for inhibiting deterioration and/or extending the shelf life of harvested fruit, vegetables, and ornamentals are disclosed.

  新型取代苯基和苄基硝基胍以及苯基和苄基氰基胍化合物。本发明公开了使用上述新型胍类化合物及其衍生物提高作物产量、抑制禾本科作物抽条和诱导作物植物细胞分裂素样反应的方法，以及抑制已收获水果、蔬菜和观赏植物变质和/或延长其货架期的方法。
• Substituted nitro and cyanoguanidines and their use for increasing crop yield
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0189579A1

  公开（公告）日：1986-08-06

  Novel substituted phenyl and benzyl nitroguanidine and phenyl and benzyl cyanoguanidine compounds. Methods for increasing crop yield, inhibiting lodging of graminaceous crops, and inducing cytokinin-like responses in crop plants with said novel guanidine compounds and derivatives thereof, as well as methods for inhibiting deterioration and/or extending the shelf life of harvested fruit, vegetables, and ornamentals are disclosed.

  新型取代苯基和苄基硝基胍以及苯基和苄基氰基胍化合物。本研究公开了利用上述新型胍类化合物及其衍生物提高作物产量、抑制禾本科作物抽条和诱导作物植物细胞分裂素样反应的方法，以及抑制已收获水果、蔬菜和观赏植物变质和/或延长其货架期的方法。
• Nitro- and cyanoguanidines as selective preemergence herbicides and plant defoliants
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0210446A2

  公开（公告）日：1987-02-04

  There are provided novel nitroguanidine and cyanoguanidine compounds. A method of dessicating and defoliating plants by applying to the foliage thereof certain nitroguanidine or cyanoguanidine compounds and a method for the selective preemergence control of undesirable broadleaf weeds and grasses in the presence of graminaceous crops are disclosed.

  本发明提供了新型硝基胍和氰基胍化合物。本发明公开了一种通过向植物叶片施用某些硝基胍或氰基胍化合物来使植物脱水和落叶的方法，以及一种在禾本科作物存在的情况下选择性芽前控制不受欢迎的阔叶杂草和禾本科杂草的方法。