2-((5-((naphthalen-1-yloxy)methyl)-1,3,4-oxadiazol-2-yl)thio)-N'-((2S,3R,4S,5R)-2,3,4,5,6-pentahydroxyhexylidene)acetohydrazide | 1248497-92-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-((5-((naphthalen-1-yloxy)methyl)-1,3,4-oxadiazol-2-yl)thio)-N'-((2S,3R,4S,5R)-2,3,4,5,6-pentahydroxyhexylidene)acetohydrazide
• CAS: 1248497-92-8
• 化学式: C₂₁H₂₄N₄O₈S
• 分子量: 492.51
• InChiKey: LBKLIADGUOJREB-BWMZKYQQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.57
• 重原子数：
  34.0
• 可旋转键数：
  12.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  190.76
• 氢给体数：
  6.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  2-((5-((naphthalen-1-yloxy)methyl)-1,3,4-oxadiazol-2-yl)thio)-N'-((2S,3R,4S,5R)-2,3,4,5,6-pentahydroxyhexylidene)acetohydrazide 、 乙酸酐 反应 1.5h， 以68%的产率得到1-[5-[[5-[(naphthalen-1-yloxy)methyl]-1,3,4-oxadiazol-2-ylthio]methyl]-2-(1,2,3,4,5-penta-O-acetyl-D-galactopentitol-1-yl)-1,3,4-oxadiazol-3(2H)-yl]ethanone
  参考文献：
  名称：

  Synthesis and antiviral evaluation of new 2,5-disubstituted 1,3,4-oxadiazole derivatives and their acyclic nucleoside analogues

  摘要：

  A number of new 5-[(naphthalen-1-yloxy)-methyl]-1,3,4-oxadiazole derivatives were synthesized. Sugar 2-[5-[(naphthalen-1-yloxy)methyl]-1,3,4-oxadiazol-2-ylthio]acetohydrazones were prepared by condensation of the hydrazide with the corresponding monosaccharides. Cyclization of the sugar hydrazones with acetic anhydride afforded the substituted oxadiazoline derivatives. The synthesized compounds displayed different degrees of antiviral activities or inhibitory actions against HCV and HIV viruses.

  DOI：

  10.1007/s00706-010-0360-y
• 作为产物：
  描述：

  ethyl 2-[5-[(naphthalen-1-yloxy)methyl]-1,3,4-oxadiazol-2-ylthio]acetate 在 一水合肼 、 溶剂黄146 作用下， 以 乙醇 、 水 为溶剂， 反应 9.0h， 生成 2-((5-((naphthalen-1-yloxy)methyl)-1,3,4-oxadiazol-2-yl)thio)-N'-((2S,3R,4S,5R)-2,3,4,5,6-pentahydroxyhexylidene)acetohydrazide
  参考文献：
  名称：

  Synthesis and antiviral evaluation of new 2,5-disubstituted 1,3,4-oxadiazole derivatives and their acyclic nucleoside analogues

  摘要：

  A number of new 5-[(naphthalen-1-yloxy)-methyl]-1,3,4-oxadiazole derivatives were synthesized. Sugar 2-[5-[(naphthalen-1-yloxy)methyl]-1,3,4-oxadiazol-2-ylthio]acetohydrazones were prepared by condensation of the hydrazide with the corresponding monosaccharides. Cyclization of the sugar hydrazones with acetic anhydride afforded the substituted oxadiazoline derivatives. The synthesized compounds displayed different degrees of antiviral activities or inhibitory actions against HCV and HIV viruses.

  DOI：

  10.1007/s00706-010-0360-y