N-(2,5-二甲氧基苯基)甲酰胺 | 71862-01-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(2,5-二甲氧基苯基)甲酰胺
• 英文名称: N-(2,5-dimethoxyphenyl)formamide
• CAS: 71862-01-6
• 化学式: C₉H₁₁NO₃
• 分子量: 181.191
• InChiKey: OLFRLRWLZRENSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2,5-二甲氧基苯基)甲酰胺 在 三乙胺 作用下， 生成 2-异氰基-1,4-二甲氧基苯
  参考文献：
  名称：

  FR1384209

  摘要：

  公开号：
• 作为产物：
  描述：

  2,5-二甲氧基苯胺 在 三氯氧磷 作用下， 以 苯 为溶剂， 反应 2.0h， 生成 N-(2,5-二甲氧基苯基)甲酰胺
  参考文献：
  名称：

  New findings on the Vilsmeier-Haack approach to quinoline derivatives

  摘要：

  The presence of electron-releasing substituents on the aromatic ring of anilides. although necessary for the Vilsmeier-Haack cyclization to quinolines to proceed efficiently, can cause failure of the expected cyclization. leading to (Z) N,N-dimethylformamidines through an alternative course. A similar behaviour is observed when pi-donor groups are introduced on the alpha position of the anilide, although in this case some cyclization to quinoline derivatives generally occurs.

  DOI：

  10.1016/s0040-4020(01)80253-2

文献信息

• Hydronopol derivatives as agonists on human ORL1 receptors
  申请人：Mentzel Matthias

  公开号：US20050131004A1

  公开（公告）日：2005-06-16

  The invention relates to a group of hydronopol derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these novel hydronopol derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1) wherein the symbols have the meanings as given in the description.

  本发明涉及一组氢诺普尔衍生物，它们是人ORL1（痛敏素）受体的激动剂。本发明还涉及这些化合物的制备方法，以及含有至少一种这些新型氢诺普尔衍生物作为活性成分的药理活性量的药物组合物，以及这些药物组合物用于治疗涉及ORL1受体的疾病的使用。本发明涉及通式（1）的化合物，其中符号的含义如说明书中所述。
• [EN] ACTIVATORS OF SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNELS AND USE THEREOF<br/>[FR] ACTIVATEURS DE CANAUX DE POTASSIUM ACTIVES PAR CALCIUM DE CONDUCTANCE FAIBLE ET UTILISATION ASSOCIEE
  申请人：GLAXO GROUP LTD

  公开号：WO2004014425A1

  公开（公告）日：2004-02-19

  The invention relates to activators of small conductance calcium potassium channels of formula (I) and their use in the treatment of disorders responsive to enhanced calcium activated potassium channel activity.

  该发明涉及公式（I）的小电导钙钾通道激动剂及其在对增强钙激活钾通道活性敏感的疾病治疗中的应用。
• Effective Synthesis of<i>N</i>-Arylformamide from α-Halo-<i>N</i>-arylacetamides
  作者：Kun-Heng Chiang、Shi-Han Lu、Wan-Ping Yen、Naoto Uramaru、Wei-Siou Tseng、Te-Wei Chang、Fung Fuh Wong

  DOI：10.1002/hc.21321

  日期：2016.7

  A convenient synthetic method for N-arylformamide derivatives was successfully developed by reacting α-iodo-N-arylacetamides with formamide. This method was applicable to α-iodo-N-arylacetamide substrates bearing electron-donating or electron-withdrawing groups, N-(benzo[d][1,3]dioxol-5-yl)-2-iodoacetamide, 2-iodo-N-(pyridin-2-yl)acetamide, and 2-iodo-N-(naphthalen-4-yl)acetamide to give the corresponding

  通过α-碘代-N-芳基乙酰胺与甲酰胺反应，成功开发了一种简便的N-芳基甲酰胺衍生物合成方法。该方法适用于带有给电子或吸电子基团的α-碘-N-芳基乙酰胺底物，N-(benzo[d][1,3]dioxol-5-yl)-2-iodoacetamide，2-iodo- N-(吡啶-2-基)乙酰胺和2-碘-N-(萘-4-基)乙酰胺以中等至极好的产率(65-94%)得到相应的N-芳基甲酰胺。提出了一种合理的机制来解释新的转变。
• Novel succinate compounds, compositions and methods of use and preparation
  申请人：——

  公开号：US20020115863A1

  公开（公告）日：2002-08-22

  Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

  揭示了一种新型羟羧酸化合物。这些羟羧酸酯抑制肽变形酶（PDF），这是一种存在于原核生物中的酶。这些羟羧酸酯可用作抗微生物和抗生素。该发明的化合物表现出对肽变形酶的选择性抑制，而不影响其他金属蛋白酶如基质金属蛋白酶（MMPs）。该文还揭示了这些化合物的合成方法和使用方法。
• Heteroarylpiperidine And-Piperazine Derivatives
  申请人：Cristau Pierre

  公开号：US20110306620A1

  公开（公告）日：2011-12-15

  Heteroarylpiperidine and -piperazine derivatives of the formula (I), in which the symbols have the meanings given in the description and agrochemically active salts thereof and their use for controlling phytopathogenic harmful fungi and also processes for preparing compounds of the formula (I).

  杂芳基哌啶和-哌嗪衍生物的化学式(I)，其中符号的含义如描述中所示，以及其农药活性盐和用于控制植物病原真菌的使用，以及制备化合物的方法的过程(I)。