3-(Aminomethyl)-4,4-dimethylazetidin-2-one | 927908-08-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 3-(Aminomethyl)-4,4-dimethylazetidin-2-one
• CAS: 927908-08-5
• 化学式: C₆H₁₂N₂O
• mdl: MFCD19215546
• 分子量: 128.174
• InChiKey: FBLKGINYVVYGFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二碳酸二叔丁酯 、 3-(Aminomethyl)-4,4-dimethylazetidin-2-one 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以2.9 g的产率得到(+/-)-3-tert-butyloxycarbonylaminomethyl-4,4-dimethyl azetidin-2-one
  参考文献：
  名称：

  Poly-β-peptides from functionalized β-lactam monomers and antibacterial compositions containing same

  摘要：

  揭示了一种制备β-多肽的方法。该方法包括在碱引发剂和不是金属含量分子的共引发剂的存在下，聚合含β-内酰胺的单体，从而产生产物β-多肽。具体揭示的方法包括基础引发剂为钾叔丁醇盐、锂双(三甲基硅基)胺(LiN(TMS)2)、双(三甲基硅基)胺钾和乙醇钠，反应在氯仿、二氯甲烷、二甲基亚砜或四氢呋喃等溶剂中进行。

  公开号：

  US09120892B2
• 作为产物：
  描述：

  N-(3-甲基-2-丁烯基)邻苯二甲酰亚胺 在 肼 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 48.0h， 生成 3-(Aminomethyl)-4,4-dimethylazetidin-2-one
  参考文献：
  名称：

  Poly-β-peptides from functionalized β-lactam monomers and antibacterial compositions containing same

  摘要：

  揭示了一种制备β-多肽的方法。该方法包括在碱引发剂和不是金属含量分子的共引发剂的存在下，聚合含β-内酰胺的单体，从而产生产物β-多肽。具体揭示的方法包括基础引发剂为钾叔丁醇盐、锂双(三甲基硅基)胺(LiN(TMS)2)、双(三甲基硅基)胺钾和乙醇钠，反应在氯仿、二氯甲烷、二甲基亚砜或四氢呋喃等溶剂中进行。

  公开号：

  US09120892B2

文献信息

• NYLON-3 CO-POLYMERS AND SYNTHETIC LUNG SURFACTANT COMPOSITIONS CONTAINING SAME
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20150231171A1

  公开（公告）日：2015-08-20

  Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins B and C (SP-B and SP-C), two helical and amphiphilic proteins that are critical for normal respiration. The generation of non-natural mimics of SP-B and SP-C has previously been restricted to step-by-step, sequence-specific synthesis, which results in discrete oligomers that are intended to manifest specific structural attributes. Presented herein an alternative approach to SP-B mimicry that is based on sequence-random copolymers containing cationic and lipophilic subunits. These materials, members of the nylon-3 family, are prepared by ring-opening polymerization of β-lactams. The best of the nylon-3 polymers display promising in vitro surfactant activities in a mixed lipid film. Pulsating bubble surfactometry data indicate that films containing the most surface-active polymers attain adsorptive and dynamic-cycling properties that surpass those of discrete peptides intended to mimic SP-B. Attachment of an N-terminal octadecanoyl unit to the nylon-3 copolymers affords further improvements by reducing the percent surface area compression to reach low minimum surface tension.
• POLY-BETA-PEPTIDES FROM FUNCTIONALIZED BETA-LACTAM MONOMERS AND ANTIBACTERIAL COMPOSITIONS CONTAINING SAME
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20150322205A1

  公开（公告）日：2015-11-12

  Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS) 2 ), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.
• US8519095B2
  申请人：——

  公开号：US8519095B2

  公开（公告）日：2013-08-27
• US9044392B2
  申请人：——

  公开号：US9044392B2

  公开（公告）日：2015-06-02
• US9120892B2
  申请人：——

  公开号：US9120892B2

  公开（公告）日：2015-09-01