N-(3-methoxy-2-hydroxypropyl)isopropylamine | 192652-11-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(3-methoxy-2-hydroxypropyl)isopropylamine
• 英文别名: 2-Propanol, 1-methoxy-3-[(1-methylethyl)amino]-；1-methoxy-3-(propan-2-ylamino)propan-2-ol
• CAS: 192652-11-2
• 化学式: C₇H₁₇NO₂
• 分子量: 147.217
• InChiKey: SNNSWIUABLWXGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(3-methoxy-2-hydroxypropyl)isopropylamine 、 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以32 mg的产率得到4-[1-(adamantane-1-carbonyl)piperidin-4-yl]-N-(2-hydroxy-3-methoxypropyl)-N-propan-2-ylpiperidine-1-carboxamide
  参考文献：
  名称：

  A Wrench-Shaped Synthetic Molecule that Modulates a Transcription Factor−Coactivator Interaction

  摘要：

  Development of synthetic molecules that provide external control over the transcription of a given gene represents a challenge in medicinal and bioorganic chemistry. Here we report design and analysis of wrenchnolol, a wrench-shaped synthetic molecule that impairs the transcription of the Her2 oncogene by disrupting association of transcription factor ESX with its coactivator Sur-2. The "jaw" part of the compound mimics the alpha-helical interface of the activation domain of ESX, and the "handle" region accepts chemical modifications for a range of analysis. A water-soluble handle permitted NMR study in aqueous solution; a biotinylated handle verified the selectivity of the interaction, and a fluorescent handle confirmed the cell permeability of the compound. The case study of wrenchnolol foreshadows the promise and the challenge of targeting protein-protein interactions in the nucleus and may lead to the development of unique synthetic modulators of gene transcription.

  DOI：

  10.1021/ja038855+
• 作为产物：
  描述：

  (2-Methoxy-1-phenylmethoxyethoxy)methylbenzene 在 四氯化碳 、 lithium aluminium tetrahydride 、 二溴二氟甲烷 、 碘化钛(IV) 、 异丙胺 作用下， 生成 cis-1,4-dimethoxy-2-butene 、 反式-1,4-二甲氧基-2-丁烯 、 N-(3-methoxy-2-hydroxypropyl)isopropylamine
  参考文献：
  名称：

  低价钛制得具有肾上腺素β-受体阻滞活性的氨基-2-丙醇结构的新途径

  摘要：

  氨基-2-丙醇结构可通过使用LVT（低价钛）加入原位生成的二卤卡宾的二苄基乙缩醛中获得。该方法可用于获得具有氨基-2-丙醇结构的肾上腺素β-受体阻滞剂。四卤甲烷是最好的二卤卡宾前体。通过添加四氯化碳可以提高使用卤代氟甲烷获得的收率。可以提出可以暗示卤素转移的方法。

  DOI：

  10.1016/s0040-4039(97)00804-6

文献信息

• Small molecule inhibitors of HER2 expression
  申请人：Uesugi Motonari

  公开号：US20050283007A1

  公开（公告）日：2005-12-22

  Peptide mimetic small molecule inhibitors of Sur-2 are provided having the general formula:

  提供了具有一般公式的Sur-2肽类模拟小分子抑制剂：
• Merged ion channel modulating compounds and Uses Thereof
  申请人：Choi Lewis S.L.

  公开号：US20090088464A1

  公开（公告）日：2009-04-02

  Merged compounds of ion channel modulating compounds, including, for example, merged compounds of the ion channel modulating compound of the following formula: (I) are described herein, as well as methods of making and using such merged compounds and pharmaceutical compositions containing such merged compounds.

  本文描述了离子通道调节化合物的合并化合物，包括以下式子的离子通道调节化合物的合并化合物：（I），以及制备和使用这种合并化合物的方法和含有这种合并化合物的药物组合物。
• COMPOSITION PHARMACEUTIQUE COMPRENANT LE BISOPROLOL ET LE PÉRINDOPRIL
  申请人：Les Laboratoires Servier

  公开号：EP3215130B1

  公开（公告）日：2020-07-08
• SILICON CONTAINING POLYMER FLOCCULANTS
  申请人：Cytec Industries Inc.

  公开号：EP3463609B1

  公开（公告）日：2020-11-18
• LIPID COMPOUNDS FOR SUPRESSION OF TUMORIGENESIS
  申请人：Svetlov Stanislav I.

  公开号：US20110177108A1

  公开（公告）日：2011-07-21

  The present invention provides compounds, or pharmaceutically acceptable salts or analogs thereof, which exhibit anti-tumor activity. The present invention also includes methods for inhibiting the growth of cancer cells by contacting an effective amount of a compound of the present invention with the cancer cells in vitro or in vivo.