2-(benzylthio)-N-hydroxyacetamide | 15909-39-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(benzylthio)-N-hydroxyacetamide
• 英文别名: N--hydroxylamin；S-benzylthioglycoloylhydroxamic acid；2-benzylsulfanyl-N-hydroxyacetamide
• CAS: 15909-39-4
• 化学式: C₉H₁₁NO₂S
• 分子量: 197.258
• InChiKey: VQLHZZHJWHPSAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  S-苄基巯基乙酸 生成 2-(benzylthio)-N-hydroxyacetamide
  参考文献：
  名称：

  关于（芳基巯基）乙酰羟肟酸的性质

  摘要：

  描述了一些取代的巯基乙酰异羟肟酸和（苯基巯基）丁酸和（苯基巯基）戊酰异羟肟酸，它们对植物病原真菌有效，讨论了一些（苯基巯基）乙酰基和（苯基磺酰基）乙酰羟肟酸的红外光谱。

  DOI：

  10.1002/ardp.19673000608

文献信息

• An Environmentally Sustainable Mechanochemical Route to Hydroxamic Acid Derivatives
  作者：Rita Mocci、Lidia De Luca、Francesco Delogu、Andrea Porcheddu

  DOI：10.1002/adsc.201600350

  日期：2016.10.6

  An operationally simple, and cost efficient conversion of carboxylic acids into hydroxamic acid derivatives via a high‐energy mechanochemical activation is presented. This ball milling methodology was applied to a wide variety of carboxylic acids dramatically improving purification issues associated with this class of molecules, which still remain one of the main bottlenecks of classical methodologies

  提出了通过高能机械化学活化将羧酸简单，经济地转化为异羟肟酸衍生物的方法。该球磨方法论已应用于多种羧酸，大大改善了与此类分子相关的纯化问题，而这些问题仍然是经典方法学的主要瓶颈之一。
• Histone deacetylase inhibitors
  申请人：CircaGen Pharmaceutical, a Delaware corporation

  公开号：US20020143037A1

  公开（公告）日：2002-10-03

  Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy.

  组蛋白去乙酰化酶是一种在活性位点含锌的金属酶。具有锌结合基团的化合物，例如，羧酸基团，可以抑制组蛋白去乙酰化酶。组蛋白去乙酰化酶的抑制可以抑制基因表达，包括与肿瘤抑制相关的基因的表达。因此，抑制组蛋白去乙酰化酶可以提供治疗癌症、血液学疾病（例如血红蛋白病）以及遗传相关代谢性疾病（例如囊性纤维化和肾上腺白质脑病）的另一途径。
• [EN] ALKYL THIOETHER ETHYL HYDROXIMIC ACID BENEFICIATION AGENT, PREPARATION METHOD THEREFOR AND USE THEREOF<br/>[FR] AGENT DE VALORISATION D'ACIDE ALKYLETHIOÉTHER ÉTHYLE HYDROXIMIQUE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION<br/>[ZH] 一种烷基硫醚基乙基羟肟酸选矿药剂及其制备方法与应用
  申请人：UNIV CENTRAL SOUTH

  公开号：WO2021042814A1

  公开（公告）日：2021-03-11

  一种烷基硫醚基乙基羟肟酸选矿药剂及其制备方法与应用，烷基硫醚基乙基羟肟酸分子同时具有硫醚基和羟肟基两种功能基，其采用烷基硫醚基乙酸与甲醇进行酯化，再采用羟胺和碱进行羟肟化得到。烷基硫醚基乙基羟肟酸选矿药剂可以用作矿物浮选的捕收剂，制备方法简单，收率高，其分子中的硫醚基和羟肟酸基团具有协同作用，可有效提高其捕收性能。
• WO2006/52916
  申请人：——

  公开号：——

  公开（公告）日：——
• ALKYL THIOETHER ETHYL HYDROXAMIC ACID BENEFICIATION REAGENT AND PREPARATION METHOD AND APPLICATION THEREOF
  申请人：CENTRAL SOUTH UNIVERSITY

  公开号：US20210276023A1

  公开（公告）日：2021-09-09

  An alkyl thioether ethyl hydroxamic acid beneficiation reagent and a preparation method and application thereof are provided. The alkyl thioether ethyl hydroxamic acid molecules have two functional groups, a thioether group and a hydroxamate group. The beneficiation reagent is obtained by esterification of alkyl thioether acetic acid and methanol and then by hydroxamation of hydroxylamine and an alkali. The alkyl thioether ethyl hydroxamic acid beneficiation reagent can be used as a collector for mineral flotation. The preparation method is simple and has a high yield. The thioether and hydroxamate group in the molecules have a synergistic effect and can effectively improve the collection performance.