amino(cyclopentylamino)dihydroxyplatinum(VI) | 1610014-98-6

• 分子结构分类: 有机化合物 - 碳氢化合物 - 多环烃
• 英文名称: amino(cyclopentylamino)dihydroxyplatinum(VI)
• CAS: 1610014-98-6
• 化学式: C₅H₁₈N₂O₂Pt
• 分子量: 333.29
• InChiKey: FAHZLUZDNURAAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  3-(nitrooxy)cyclobutane-1,1-dicarboxylic acid 、 amino(cyclopentylamino)dihydroxyplatinum(VI) 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 24.0h， 以0.31 g的产率得到cis-[Pt(cyclopentylamine)(NH3)(3-(nitroxy)cyclobutane-1,1-dicarboxylate)2]
  参考文献：
  名称：

  Synthesis and biological evaluation of mixed ammine/amine platinum(II) complexes with dicarboxylate containing organic nitrate as ligand

  摘要：

  Two novel platinum(II) complexes cis-[Pt(L')(NH3)X] (where L' = cyclopentylamine or cyclohexylamine, X = 3-(nitrooxy)cyclobutane-1,1-dicarboxylate) were synthesized and spectrally characterized in this study. The purity of complexes 1 and 2 were studied by HPLC-MS spectra, and the contents of complexes 1 and 2 were more than 98%. It was demonstrated that the newly synthesized compounds with dicarboxylate containing organic nitrate as ligand possessed DNA unwinding capability similar to cisplatin by the means of agarose gel electrophoresis. In addition, the antiproliferative study by WST-8 assay revealed that these platinum(II) complexes exhibited considerable cytotoxicity against tested cancer cell lines in vitro compared with positive agents (cisplatin, oxaliplatin and carboplatin), especially complex 1, showing higher in vitro antitumoractivity than oxaliplatin and carboplatin in SGC7901 and A549 cell lines. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.09.034
• 作为产物：
  描述：

  水 、 (ammonia)(cyclopentylamine)diiodoplatinum(II) 在 silver nitrate 作用下， 反应 24.0h， 生成 amino(cyclopentylamino)dihydroxyplatinum(VI)
  参考文献：
  名称：

  Synthesis and biological evaluation of mixed ammine/amine platinum(II) complexes with dicarboxylate containing organic nitrate as ligand

  摘要：

  Two novel platinum(II) complexes cis-[Pt(L')(NH3)X] (where L' = cyclopentylamine or cyclohexylamine, X = 3-(nitrooxy)cyclobutane-1,1-dicarboxylate) were synthesized and spectrally characterized in this study. The purity of complexes 1 and 2 were studied by HPLC-MS spectra, and the contents of complexes 1 and 2 were more than 98%. It was demonstrated that the newly synthesized compounds with dicarboxylate containing organic nitrate as ligand possessed DNA unwinding capability similar to cisplatin by the means of agarose gel electrophoresis. In addition, the antiproliferative study by WST-8 assay revealed that these platinum(II) complexes exhibited considerable cytotoxicity against tested cancer cell lines in vitro compared with positive agents (cisplatin, oxaliplatin and carboplatin), especially complex 1, showing higher in vitro antitumoractivity than oxaliplatin and carboplatin in SGC7901 and A549 cell lines. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.09.034