N1-乙基己烷-1,6-二胺 | 40043-26-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N1-乙基己烷-1,6-二胺
• 英文名称: N-ethylhexane-1,6-diamine
• 英文别名: N-ethyl-hexanediyldiamine；N-Aethyl-hexandiyldiamin；N'-ethylhexane-1,6-diamine
• CAS: 40043-26-3
• 化学式: C₈H₂₀N₂
• 分子量: 144.26
• InChiKey: GODRGSBJTFNCPC-UHFFFAOYSA-N

物化性质

• 沸点：
  82-84 °C(Press: 5 Torr)
• 密度：
  0.8431 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2921290000

反应信息

• 作为反应物：
  描述：

  9-氯吖啶 、 N1-乙基己烷-1,6-二胺 在 苯酚 作用下， 以60%的产率得到N-Acridin-9-yl-N'-ethyl-hexane-1,6-diamine; hydrochloride
  参考文献：
  名称：

  脂肪族二，三和四胺的9-ac啶基和2-甲氧基-6-氯-9-rid啶基衍生物。化学，细胞抑制活性和血吸虫活性。

  摘要：

  1,6-己二胺，1,8-辛二胺，双（3-氨基丙基）胺，N，N'-双（3-氨基丙基）哌嗪和N-乙基-1,6-己二胺的9-ac啶基衍生物以高收率制备它们的盐酸盐形式的草甘膦，并将其转化成潜在的插入双异核苷的杂双DNA。通过将上述胺与9-氯ac啶一起加热来制备相应的潜在的均双bis DNA插入试剂。检查了idine啶的化学稳定性。已经确定了它们在体外对Cloudman黑色素瘤细胞的细胞抑制活性。对于三胺和四胺的cr啶衍生物观察到最强的细胞抑制活性。发现所选的a啶和二cr啶衍生物在小鼠中对曼氏血吸虫的血吸虫杀伤作用微不足道。S.

  DOI：

  10.1021/jm00364a028
• 作为产物：
  描述：

  1,6-己二胺 、 乙醛 在 水 作用下， 生成 N1-乙基己烷-1,6-二胺
  参考文献：
  名称：

  Wittbecker; Houtz; Watkins, Journal of the American Chemical Society, 1947, vol. 69, p. 580

  摘要：

  DOI：

文献信息

• 12-EPI PLEUROMUTILINS
  申请人：NABRIVA THERAPEUTICS AG

  公开号：US20160332963A1

  公开（公告）日：2016-11-17

  A compound selected from 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-sulfanyl)-acetyl]-12-epi-mutilins, or 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-oxy)-acetyl]-12-epi-mutilins, wherein 12-epi-mutilin is characterized in that the mutilin ring at position 12 is substituted by two substituents, the first substituent at position 12 of the mutilin ring is a methyl group which methyl group has the inverse stereochemistry compared with the stereochemistry of the methyl group at position 12 of the naturally occurring pleuromutilin ring, the second substituent at position 12 of the mutilin ring is a hydrocarbon group comprising at least one nitrogen atom and all other substituents of the mutilin ring having the same stereochemistry compared with the stereochemistry of the substituents at the corresponding positions in the naturally occurring pleuromutilin ring; optionally in the form of a salt and/or solvate, wherein the naturally occurring pleuromutilin is of formula processes for the preparation of such compounds and their use as pharmaceuticals.

  从14-O-[((烷基、环烷基、杂环烷基、杂环芳基或芳基)-硫基)-乙酰基]-12-epi-木替林，或14-O-[((烷基、环烷基、杂环烷基、杂环芳基或芳基)-氧基)-乙酰基]-12-epi-木替林中选择的一种化合物，其中12-epi-木替林的特征在于木替林环在位置12被两个取代基取代，木替林环在位置12的第一个取代基是一个甲基基团，该甲基基团的立体化学与天然存在的普鲁木替林环在位置12的甲基基团的立体化学相反，木替林环在位置12的第二个取代基是一个含有至少一个氮原子的碳氢基团，木替林环的所有其他取代基与天然存在的普鲁木替林环中相应位置的取代基的立体化学相同；可选地以盐和/或溶剂的形式存在，其中天然存在的普鲁木替林的化学式为 制备这类化合物的方法以及它们作为药物的用途。
• NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
  申请人：BERNHART Claude

  公开号：US20100222319A1

  公开（公告）日：2010-09-02

  The disclosure relates to compounds of formula (I): wherein A, Z, Z′, L, R 2 and R 3 are as defined in the disclosure, to compositions comprising said compounds, and to methods for the manufacture and therapeutic use thereof.

  该公开涉及到式(I)的化合物： 其中A、Z、Z'、L、R2和R3如公开所定义，以及包含该化合物的组合物，以及用于其制备和治疗用途的方法。
• CROSSLINKABLE POLYMER MATERIAL, CROSSLINKED POLYMER MATERIAL, AND PRODUCTION METHOD THEREOF
  申请人：SEO Akishige

  公开号：US20120046418A1

  公开（公告）日：2012-02-23

  The present invention provides a production method of a crosslinkable polymer material which includes adding 2-(glycidyloxy)-1-naphthonitrile oxide or 2-[5-(ethoxycarbonyl)pentyloxy]-1-naphthonitrile oxide by an addition reaction to a polymer material having a multiple bond to which a nitrile oxide is added by an addition reaction so as to introduce a glycidyl group or an ethoxycarbonyl group into the polymer material.

  本发明提供了一种交联聚合物材料的生产方法，其中包括将2-（环氧丙基）-1-萘硝基氧化物或2- [5-（乙氧羰基）戊氧基] -1-萘硝基氧化物通过加成反应添加到具有多重键的聚合物材料中，该聚合物材料通过加成反应添加了硝基氧化物，以便将环氧丙基或乙氧羰基引入聚合物材料中。
• Photosensitive composition
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0312624A1

  公开（公告）日：1989-04-26

  The present invention relates to a photosensitive composition containing at least one compound selected from the group consisting of N-acyl amino acid derivatives, hydroxycarboxylic acids and their derivatives, condensates of an aliphatic or aromatic aldehyde with a polyhydric alcohol, acylated polysaccharides and metallic soaps. From the photosensitive composition of the present invention, moldings having excellent shape retentivity and/or compatibility of the components thereof with one another can be produced. Therefore, the production of moldings from a composition which has been heretofore impossible is made possible. Particularly a composition having a good moldability during the molding operation can be employed. The composition is useful for the preparation of printing plate materials having a good developability and printing plates, particularly flexible printing plates and flexographic printing plates, having an improved ink solvent resistance.

  本发明涉及一种光敏组合物，该组合物含有至少一种选自 N-酰基氨基酸衍生物、羟基羧酸及其衍生物、脂肪醛或芳香醛与多元醇的缩合物、酰化多糖和金属皂的化合物。利用本发明的光敏组合物，可以生产出具有极佳形状保持性和/或其各组分之间相容性的模塑件。因此，利用本发明的组合物生产模塑件成为可能，而这在以前是不可能的。特别是可以使用在成型操作过程中具有良好成型性的组合物。该组合物可用于制备显影性良好的印版材料和耐油墨溶剂性更好的印版，特别是柔性印版和柔性版印刷印版。
• Thermoplastic resin composition
  申请人：IDEMITSU PETROCHEMICAL COMPANY LIMITED

  公开号：EP0558048A1

  公开（公告）日：1993-09-01

  There is disclosed a thermoplastic resin composition comprising as principal components a [A] thermoplastic resin having a functional group reactive with an amino group, a [B] olefinic polymer and/or styrenic polymer, the subtotal of the above [A]+[B] being 100 parts by weight, and 0.05 to 20 parts by weight of a [C] copolymer having in a molecule thereof a formamide group and/or an amino group or a salt thereof, said copolymer having the repeating unit I, II, III or IV represented by the general formula (I), (II), (III) or (IV), respectively, wherein Y is a group selected from the general formula         -NH-R¹³   (VII) and other symbols are as defined in the specification. The above composition is excellent in impact characteristics, especially surface impact characteristics and appearance, minimized in coloration and free from delamination and peeling.

  本发明公开了一种热塑性树脂组合物，其主要成分包括具有与氨基反应的官能团的[A]热塑性树脂、[B]烯烃聚合物和/或苯乙烯聚合物，上述[A]+[B]的小计为100份（重量），以及0.05 至 20 重量份的[C]共聚物，其分子中含有甲酰胺基和/或氨基或其盐，所述共聚物具有分别由通式(I)、(II)、(III)或(IV)表示的重复单元 I、II、III 或 IV、 其中 Y 是选自通式的基团 -NH-R¹³（VII） 和其他符号在说明书中定义。上述组合物具有优异的抗冲击特性，尤其是表面抗冲击特性和外观，着色少，无分层和剥落。