(3R,3aS.6R,6aS)hexahydrofuro[3,2-b]furan-3,6-diol | 28948-16-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• 英文名称: (3R,3aS.6R,6aS)hexahydrofuro[3,2-b]furan-3,6-diol
• 英文别名: dianhydromannitol；isoidide；isoiodide；1,4;3,6-dianhydro-D-iditol；1,4;3,6-Dianhydro-D-idit；1.4:3.6-Dianhydro-D-iditol；(3R,3aS,6R,6aS)-Hexahydrofuro[3,2-b]furan-3,6-diol；(3R,3aS,6R,6aS)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol
• CAS: 28948-16-5
• 化学式: C₆H₁₀O₄
• 分子量: 146.143
• InChiKey: KLDXJTOLSGUMSJ-ZXXMMSQZSA-N

物化性质

• 熔点：
  63-64 °C(Solv: ethyl acetate (141-78-6))
• 沸点：
  160 °C(Press: 0.08 Torr)
• 密度：
  1.475±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (3R,3aS.6R,6aS)hexahydrofuro[3,2-b]furan-3,6-diol 在 吡啶 、 甲基磺酰氯 作用下， 生成 bis-O-methanesulfonyl-1,4;3,6-dianhydro-D-iditol
  参考文献：
  名称：

  264.多元醇的酸酐。第七部分 1：4-3：6-Dianhydro- d -和-升-iditol

  摘要：

  DOI：

  10.1039/jr9470001403
• 作为产物：
  描述：

  O¹,O²;O⁵,O⁶-diisopropylidene-O³,O⁴-bis-(toluene-4-sulfonyl)-D-mannitol 生成 (3R,3aS.6R,6aS)hexahydrofuro[3,2-b]furan-3,6-diol
  参考文献：
  名称：

  D-甘露糖醇的某些磺酸酯与甲醇的反应；2,3：4,5-二脱水-D-iditol的合成

  摘要：

  摘要合成并结晶了3,4-二-O-（甲基磺酰基）-和3,4-二-O-对甲苯磺酰基-D-甘露糖醇及其1,2,5,6-四乙酸酯。在25°C下2小时内，通过过量甲醇甲醇钡的作用，将这些化合物中的每一种转化为2,3：4,5-二氢-D-ID醇，其结构根据化学和化学式确定。物理性质，包括核磁共振光谱证据。

  DOI：

  10.1016/s0008-6215(00)81197-0

文献信息

• SULFOXIMINE SUBSTITUTED QUINAZOLINES FOR PHARMACEUTICAL COMPOSITIONS
  申请人：BLUM Andreas

  公开号：US20140135309A1

  公开（公告）日：2014-05-15

  This invention relates to novel sulfoximine substituted quinazoline derivatives of formula I wherein Ar, R 1 and R 2 are as defined herein, and their use as MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) kinase inhibitors, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment or amelioration of MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) mediated disorders.

  这项发明涉及公式I的新型磺酰胺取代的喹唑啉衍生物，其中Ar、R1和R2如本文所定义，并且它们作为MNK1（MNK1a或MNK1b）和/或MNK2（MNK2a或MNK2b）激酶抑制剂的用途，含有这些化合物的药物组合物，以及将其用作治疗或改善MNK1（MNK1a或MNK1b）和/或MNK2（MNK2a或MNK2b）介导的疾病的药剂的方法。
• Anhydro Sugar Formation in Acid and Base Hydrolyses of 3,4-Di-<i>O</i>-methylsulfonyl-<scp>D</scp>-mannitol: a Rapid Route to 1,4:3,6-Dianhydro-<scp>D</scp>-iditol(<scp>D</scp>-Isoidide)
  作者：David Roy Hicks、Bert Fraser-Reid

  DOI：10.1139/v74-496

  日期：1974.10.1

  Brief acid hydrolysis of 1,2:5,6-di-O-isopropylidene-3,4-di-O-methylsulfonyl-D-mannitol (1a), removes the isopropylidene groups giving the disulfonated hexitol, 2a. Upon continued acid hydrolysis of 2a, one sulfonate group is lost with formation of a sulfonated monoanhydro hexitol, 5a, then the second ester group is lost to give 1,4:3,6-dianhydro-D-iditol (D-isoidide, 3a). If the disulfonate, 2a, is treated with base, an isomeric dianhydro hexitol, the bisoxirane 4, is formed. Under similar basic conditions, the monoanhydro hexitol, 5a, is stable. On acid hydrolysis, the bisoxirane, 4, gives hexitols and only 20% of D-isoidide, which indicates that 4 cannot be an intermediate in the conversion of 2a to 3a. These results indicate that, in 2a at least, five-membered anhydro rings are formed preferentially in acid hydrolyses and three-membered rings in saponification.The stage and course of hydrolysis of 2a are readily monitored by observing the τ 4–6 region in the n.m.r. spectra of D₂O samples of the hydrolysate.

  1,2:5,6-二-O-异丙基亚甲基-3,4-二-O-甲基磺酰-D-甘露醇（1a）的简短酸水解去除了异丙基亚甲基基团，得到了二磺酸基六元醇2a。继续对2a进行酸水解，一个磺酸基被失去，形成了磺化的单缺水六元醇5a，然后第二个酯基被失去，得到1,4:3,6-二缺水-D-异赛奥糖醇（D-异赛糖，3a）。如果将二磺酸盐2a用碱处理，将形成异构的二缺水六元醇，双环氧丙烷4。在类似的碱性条件下，单缺水六元醇5a是稳定的。在酸水解中，双环氧丙烷4会产生己糖醇，只有20%的D-异赛糖，这表明4不能是将2a转化为3a的中间体。这些结果表明，至少在2a中，酸水解中首选形成五元缺水环，皂化中形成三元环。通过观察水解产物的D₂O样品的n.m.r.光谱中的τ 4–6区域，可以方便地监测2a的水解阶段和过程。
• DIISOCYANATE COMPOUND HAVING ANHYDROSUGAR ALCOHOL CORE AND PREPARATION METHOD THEREFOR
  申请人：SAMYANG CORPORATION

  公开号：US20210309670A1

  公开（公告）日：2021-10-07

  The present invention relates to a diisocynate compound having anhydrosugar alcohol core and a preparation method therefor and, more specifically, to a diisocynate compound having anhydrosugar alcohol core and a preparation method therefor, wherein the diisocynate compound is prepared through a reaction with a nitrile compound, a hydrogenation reaction, and an end-group substitution reaction while a recyclable, plant-based anhydrosugar alcohol or anhydrosugar alcohol-alkylene glycol is used as a raw material, and the diisocynate compound can be utilized in various fields, such as soft or hard polyurethane expanded foams, molded foams, coating, adhesives or glues, fibers, and polymer synthesis.

  本发明涉及具有无水糖醇核的二异氰酸酯化合物及其制备方法，更具体地说，涉及一种具有无水糖醇核的二异氰酸酯化合物及其制备方法，其中该二异氰酸酯化合物是通过与腈化合物的反应、氢化反应和末端基团置换反应制备的，同时使用可回收的植物基无水糖醇或无水糖醇-烷基二醇作为原料，该二异氰酸酯化合物可用于各种领域，如软质或硬质聚氨酯发泡体、模塑泡沫、涂料、粘合剂或胶水、纤维和聚合物合成。
• [EN] DIALLYL ETHERS OF ANHYDROHEXITOLS AND PROCESSES FOR MAKING THE SAME<br/>[FR] DIALLYLÉTHERS D'ANHYDROHEXITOLS ET LEURS PROCÉDÉS DE PRÉPARATION
  申请人：ARCHER DANIELS MIDLAND CO

  公开号：WO2013188004A1

  公开（公告）日：2013-12-19

  The invention concerns diallylisoidide in a first aspect, and in a related aspect concerns an improved method for making the diallyl ether derivatives of anhydrohexitols generally, whether isosorbide, isomannide, isoidide or a mixture of two or all three of these, whereby these derivatives may be produced efficiently up to quantitative yields.

  该发明涉及二烯丙基异噻唑啉的第一方面，以及相关方面涉及改进的方法，用于制备各种无水己糖醇的二烯丙基醚衍生物，无论是异山梨醇，异甘醇，异噻唑醇还是这些的两种或全部混合物，从而可以高效地生产这些衍生物，产率高达定量收率。
• CYCLIC METHYLENE ACETAL STABILITIES IN DIANHYDROHEXITOLS
  作者：Samuel B. Baker

  DOI：10.1139/v53-111

  日期：1953.9.1

  Ring closure at the 1,4-3,6-positions in monomethylenated mannitol and iditol imparts considerable lability to the cyclic methylene acetal group. The two derivatives, 1,4-3,6-dianhydro-2,5-methylen...

  单亚甲基甘露醇和艾杜醇中 1,4-3,6-位的环闭合赋予环状亚甲基缩醛基团相当大的不稳定性。这两种衍生物，1,4-3,6-二脱水-2,5-亚甲基...