1,4,3,6-dianhydrofructose

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• 英文名称: 1,4,3,6-dianhydrofructose
• 英文别名: 1,4,3,6-Dianhydrosorbitol；(3R,3aS,6aR)-3-hydroxy-2,3,3a,6a-tetrahydrofuro[3,2-b]furan-6-one
• 化学式: C₆H₈O₄
• 分子量: 144.127
• InChiKey: DBJHHAAUYAIFCX-PYWDMBMJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,4,3,6-dianhydrofructose 生成 [(3R,3aR,6aR)-6-oxo-2,3,3a,6a-tetrahydrofuro[3,2-b]furan-3-yl] nitrate
  参考文献：
  名称：

  STOSS, PETER;LEITOLD, MATVAS

  摘要：

  DOI：
• 作为产物：
  描述：

  D-isoidite dinitrate 400.0~450.0 ℃ 、6.67 Pa 条件下， 生成 1,4,3,6-dianhydrofructose 、 1,4,3,6-dianhydromannopyranose
  参考文献：
  名称：

  制备型闪蒸真空热解。异甘露糖和硝酸异山梨酯的均相裂解为1,4,3,6-二脱水己糖

  摘要：

  1,4,3,6-dianhydromannopyranose（3）可以通过快速真空热解硝酸异甘露酯（1）来制备，而其差向异构体异山梨醇二硝酸酯（2）则可以得到（3）和1,4,3,6的混合物。-双脱水果糖（5），反映了在顺式-融合的呋喃呋喃自由基中间基团中可能发生的重排数量受限，在一种情况下具有构型反转的情况。

  DOI：

  10.1039/c39870001397

文献信息

• SULFOXIMINE SUBSTITUTED QUINAZOLINES FOR PHARMACEUTICAL COMPOSITIONS
  申请人：BLUM Andreas

  公开号：US20140135309A1

  公开（公告）日：2014-05-15

  This invention relates to novel sulfoximine substituted quinazoline derivatives of formula I wherein Ar, R 1 and R 2 are as defined herein, and their use as MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) kinase inhibitors, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment or amelioration of MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) mediated disorders.

  这项发明涉及公式I的新型磺酰胺取代的喹唑啉衍生物，其中Ar、R1和R2如本文所定义，并且它们作为MNK1（MNK1a或MNK1b）和/或MNK2（MNK2a或MNK2b）激酶抑制剂的用途，含有这些化合物的药物组合物，以及将其用作治疗或改善MNK1（MNK1a或MNK1b）和/或MNK2（MNK2a或MNK2b）介导的疾病的药剂的方法。
• [EN] POLYCYCLIC COMPOUNDS<br/>[FR] COMPOSÉS POLYCYCLIQUES
  申请人：REUTER CHEMISCHE APPBAU E K

  公开号：WO2020079225A1

  公开（公告）日：2020-04-23

  The present invention relates to compounds of the formula (I), which are suitable as monomers for preparing thermoplastic resins having beneficial optical properties and which can be used for producing optical devices. In Formula (I), A1, A2 are selected from mono- or bicyclic aromatic radicals and mono- or bicyclic heteroaromatic radicals; X represents e.g. a single bond, O, NH, CR6R7; Y is e.g. absent or represents a single bond, O, NH, CR8R9; R1, R2 are hydrogen, a radical Ar' or a radical Ra; R3 is Alk, O-Alk'-, O-Alk'-[O-Alk']o, O-CH2-Ar-C(O)-, O-C(O)-Ar-C(O)-or O-Alk-C(O)-,where in the last five moieties the left O is bound to A1 and A2, respectively; m, n are 0, 1 or 2; o is an integer from 1 to 10; R4, R5 are e.g. selected from CN and a radical Ra; R6, R8 are e.g. selected from hydrogen, a radical Ar' and a radical Ra; R7, R9 are e.g. selected from hydrogen, C1-C4-alkyl and a radical Ar'; Ra is selected from the group consisting of C≡C-R11 and Ar-C≡C-R11; R11 is e.g. selected from hydrogen, methyl, mono- or polycyclic aryl having from 6 to 26 carbon atoms and mono- or polycyclic hetaryl having a total of 5 to 26 atoms, which are ring members, where 1, 2, 3 or 4 of the ring atoms of hetaryl are selected from nitrogen, sulphur and oxygen, while the remainder of these atoms are carbon atoms, where mono- or polycyclic aryl are unsubstituted or substituted; and Ar is e.g. phenylene or naphthylene. The invention also relates to thermoplastic resins comprising a polymerized unit of the compound of formula (I) and to optical devices made of such resins.

  本发明涉及公式（I）的化合物，这些化合物适用作为单体制备具有有益光学性能的热塑性树脂，并可用于制造光学器件。在公式（I）中，A1、A2选自单环或双环芳香基团和单环或双环杂芳基团；X代表例如单键，O，NH，CR6R7；Y例如缺失或代表单键，O，NH，CR8R9；R1、R2为氢，基团Ar'或基团Ra；R3为Alk，O-Alk'-，O-Alk'-[O-Alk']o，O-CH2-Ar-C(O)-，O-C(O)-Ar-C(O)-或O-Alk-C(O)-，在最后五个基团中，左侧的O分别与A1和A2结合；m、n为0、1或2；o为1到10的整数；R4、R5例如选自CN和基团Ra；R6、R8例如选自氢，基团Ar'和基团Ra；R7、R9例如选自氢，C1-C4-烷基和基团Ar'；Ra选自C≡C-R11和Ar-C≡C-R11的组，R11例如选自氢，甲基，含有6到26个碳原子的单环或多环芳基和含有总共5到26个原子的单环或多环杂芳基，其中环原子中的1、2、3或4个来自氮、硫和氧，其余原子为碳原子，其中单环或多环芳基是未取代或取代的；Ar例如苯基或萘基。该发明还涉及包含公式（I）化合物聚合单元的热塑性树脂以及由这种树脂制成的光学器件。
• METHOD FOR THE SYNTHESIS OF PRIMARY ISOHEXIDE AMINES
  申请人：RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHLULE (RWTH) AACHEN

  公开号：US20170174698A1

  公开（公告）日：2017-06-22

  A method for synthesizing a primary amine, having the steps of: a) providing at least one dianhydrohexitol, and b) aminating the dianhydrohexitol by reacting same with ammonia, the amination being performed by heterogeneous catalysis using a hydrogenation catalyst in the presence of hydrogen.

  一种合成初级胺的方法，包括以下步骤：a）提供至少一种二酸脱水己糖，并且b）通过使用氢化催化剂在氢气存在下进行异相催化反应，将氨与二酸脱水己糖进行胺化反应。
• Aminopropanol derivatives of 1,4:3,6-dianhydro-hexitol nitrates, processes for their preparation and their use as medicaments
  申请人：Heinrich Mack Nachf.

  公开号：EP0319030A1

  公开（公告）日：1989-06-07

  Novel aminopropanol derivatives of 1,4:3,6-dianhydro-hexitol nitrates of the general formula I in which X has the meaning given in the specification, processes for their preparation and their use in preventing and treating cardiovascular diseases, angina pectoris and pulmonary hypertension in mammals.

  该专利描述了一种通式I的1,4:3,6-二脱水己糖硝酸盐的新型氨基丙醇衍生物，其中X的含义在说明书中给出，以及制备它们的过程以及在哺乳动物中预防和治疗心血管疾病、心绞痛和肺动脉高压方面的用途。
• METHOD FOR PRODUCING DIANHYDROHEXITOL WITH A STEP OF DISTILLATION ON A THIN-FILM EVAPORATOR
  申请人：ROQUETTE FRERES

  公开号：US20190092782A1

  公开（公告）日：2019-03-28

  A method for producing 1,4:3,6-dianhydrohexitols, including the steps of: a) supplying at least one hexitol, b) dehydrating the hexitol, and c) distillating the dehydration product produced in step b), wherein: the hexitol is supplied in the form of an aqueous solution in step a); and the distillation is carried out by means of a thin-film evaporator in step c).

  一种生产1,4：3,6-二脱水己醇的方法，包括以下步骤：a）提供至少一种己醇，b）脱水己醇，c）蒸馏步骤b）产生的脱水产物，其中：在步骤a）中以水溶液的形式提供己醇；在步骤c）中通过薄膜蒸馏器进行蒸馏。