N-(3-pyridylmethylidene)-2-(N,N-dimethylamino)ethylamine | 119382-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(3-pyridylmethylidene)-2-(N,N-dimethylamino)ethylamine
• 英文别名: N-nicotinylidene-N',N'-dimethylethylenediamine；N,N-dimethyl-2-(pyridin-3-ylmethylideneamino)ethanamine
• CAS: 119382-72-8
• 化学式: C₁₀H₁₅N₃
• 分子量: 177.249
• InChiKey: MARPVHNYNQXTNR-UHFFFAOYSA-N

物化性质

• 沸点：
  271.6±20.0 °C(Predicted)
• 密度：
  0.96±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(3-pyridylmethylidene)-2-(N,N-dimethylamino)ethylamine 在 sodium tetrahydroborate 、 盐酸 作用下， 以 乙醇 、 1,4-二氧六环 为溶剂， 反应 2.0h， 生成 1-(3-pyridyl)-5-methyl-2,5-diazahexane trihydrochloride
  参考文献：
  名称：

  Heterocyclic Diamines with Leishmanicidal Activity

  摘要：

  DOI：

  10.1021/acsinfecdis.1c00215
• 作为产物：
  描述：

  3-吡啶甲醛 、 N,N-二甲基乙二胺 以 甲苯 为溶剂， 以87%的产率得到N-(3-pyridylmethylidene)-2-(N,N-dimethylamino)ethylamine
  参考文献：
  名称：

  具有杂环配体的环金属化铂配合物

  摘要：

  [Pt组成的反应2我4（μ-SMe的2）2 ]与亚胺配位体从3-糠醛，3-或4-吡啶醛和派生Ñ，Ñ二甲基乙二胺，和3-糠醛和氯苄胺被报告。呋喃配体通过氮供体与铂配位，在苛刻条件下可能被迫原金属化。具有吡啶环的配体仅给出该配体对二甲基硫化物的取代。还报道了原金属化配合物与甲基碘的氧化加成反应以及配合物与三苯基膦的反应。观察到原金属化环的芳香性与络合物的反应性之间的相关性。

  DOI：

  10.1016/j.jorganchem.2004.01.026

文献信息

• Stereoselective synthesis of anti-PAF active thiazolidin-4-ones via cyclo-condensation of alkyl α-mercaptocarboxylates with arylimines
  作者：Yoo Tanabe、Yoshi-no Kubota、Yuzuru Sanemitsu、Nobushige Itaya、Gohfu Suzukamo

  DOI：10.1016/s0040-4039(00)92634-0

  日期：1991.1

  Two distinctive methods for the synthesis of cis- and trans-2, 5-disubstituted-thiazolidin-4-ones via stereoselective cyclo-condensation between α-mercaptocarboxylic esters and arylimines have been developed. With the new reaction used as the key step, two sets of optically active anti-PAF active thiazolidin-4-ones were synthesized.

  已经开发出两种独特的方法，其通过α-巯基羧酸酯和芳胺的立体选择性环缩合合成顺式和反式-2，5-二取代-噻唑烷-4-酮。以新的反应为关键步骤，合成了两套光学活性的抗PAF活性噻唑烷酮-4-酮。
• Cyclometallated platinum complexes with heterocyclic ligands
  作者：Craig Anderson、Margarita Crespo

  DOI：10.1016/j.jorganchem.2004.01.026

  日期：2004.5

  The furane ligands coordinated to platinum through the nitrogen donor and could be forced to orthometallate under severe conditions. The ligands with pyridine rings gave only substitution of the ligand for the dimethylsulphide. The oxidative addition reactions of the orthometallated complexes with methyl iodide as well as the complexes' reactions with triphenylphosphine are also reported. Correlation

  [Pt组成的反应2我4（μ-SMe的2）2 ]与亚胺配位体从3-糠醛，3-或4-吡啶醛和派生Ñ，Ñ二甲基乙二胺，和3-糠醛和氯苄胺被报告。呋喃配体通过氮供体与铂配位，在苛刻条件下可能被迫原金属化。具有吡啶环的配体仅给出该配体对二甲基硫化物的取代。还报道了原金属化配合物与甲基碘的氧化加成反应以及配合物与三苯基膦的反应。观察到原金属化环的芳香性与络合物的反应性之间的相关性。
• Certain pyridyl-thiazolidin-4-one having anti-ulcer activity
  申请人：Sumitomo Pharmaceuticals Company, Limited

  公开号：US05021435A1

  公开（公告）日：1991-06-04

  A 2-pyridyl-thiazolidin-4-one derivative represented by the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each a hydrogen atom, an C.sub.1 -C.sub.20 alkyl group, an C.sub.2 -C.sub.20 alkenyl group, an C.sub.2 -C.sub.20 alkynyl group, an aryl group, a C.sub.3 -C.sub.8 cycloalkyl group or an aralkyl group which may have a substituent, R.sub.3 is a hydrogen atom, an C.sub.1 -C.sub.20 alkyl group, an C.sub.2 -C.sub.20 alkenyl group, an C.sub.2 -C.sub.20 alkynyl group, a C.sub.3 -C.sub.8 cycloalkyl group or an aralkyl group which may have a substituent, P is a pyridyl group or its N-substituted pyridinium salt which may have a substituent, said substituent being selected from the group consisting of halogen atom, cyano group, hydroxy group, amino group, lower alkyl group, lower alkoxy group, lower alkylamino group, halogenated lower alkyl group, acyl group, acyloxy group, acylthio group, acylamino group, carboxyl group, lower alkoxycarbonyl group, carbamoyl group, lower alkyl substituted carbamoyl group, heterocyclic group, and lower cycloalkyl group, and n represents an integer of 0, 1 or 2, or a pharmaceutically acceptable salts thereof and an anti-ulcer agent which contains, as an effective ingredient, said 2-pyridyl-thiazolidine-4-one derivative or a pharmaceutically acceptable salt thereof.

  该化合物为2-吡啶基噻唑啉-4-酮衍生物，其化学式为：##STR1## 其中，R1和R2分别为氢原子、C1-C20烷基、C2-C20烯基、C2-C20炔基、芳基、C3-C8环烷基或有取代基的芳基烷基；R3为氢原子、C1-C20烷基、C2-C20烯基、C2-C20炔基、C3-C8环烷基或有取代基的芳基烷基；P为吡啶基或其N-取代吡啶盐，其取代基选自卤素原子、氰基、羟基、氨基、低碳基、低烷氧基、低烷基氨基、卤代低碳基、酰基、酰氧基、酰硫基、酰氨基、羧基、低烷氧羰基、氨基甲酰基、杂环基和低环烷基，n为0、1或2的整数。该化合物或其药学上可接受的盐可用作抗溃疡药物的有效成分。
• Thiazolidin-4-one derivatives and acid addition salts thereof useful for
  申请人：Sumitomo Chemical Company, Limited

  公开号：US05106860A1

  公开（公告）日：1992-04-21

  Thiazolidin-4-one derivative represented by the following general formula (I) and acid addition salts thereof ##STR1## wherein; R.sup.1 and R.sup.2 are the same or different and denote each (i) a residue represented by the general formula --A--R.sup.4 wherein, A denotes a single bond, C.sub.1 -C.sub.8 alkylene, C.sub.2 -C.sub.8 alkenylene, or C.sub.2 -C.sub.8 alkynylene and R.sup.4 denotes hydrogen, C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.3 -C.sub.8 cycloalkyl, or C.sub.1 -C.sub.6 haloalkyl,or (ii) a residue represented by the general formula ##STR2## wherein, B denotes a single bond or C.sub.1 -C.sub.6 alkylene, R.sup.5 denotes hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.3 -C.sub.8 cycloalkyl, substituted silyl, or substituted or unsubstituted aryl, n and n' denote each an integer of 2 to 4, m denotes an integer of 1 to 3, and m' denotes an integer of 0 to 2; R.sup.3 denotes hydrogen, C.sub.1 -C.sub.2 alkyl, allyl, 2-propynyl, or (c) the general formula --F--R.sup.9 wherein, F denotes C.sub.2 -C.sub.6 alkylene and R.sup.9 denotes a nitrogen-containing heterocyclic aromatic residue or an amino group represented by the general formula ##STR3## (R.sup.10 denotes hydrogen, C.sub.2 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkanoyl and R.sup.11 denotes hydrogen or C.sub.1 -C.sub.4 alkyl or R.sup.10 in combination with R.sup.11 denotes a 5- to 7-membered cyclic amino group which optionally contains other hetero atoms. Having selective PAF-antagonistic activities, these compounds are very useful as preventive and curative agents for PAF-induced diseases, for example, various kinds of inflammation, allergic diseases, circulatory diseases, and gastro-intestinal diseases.

  以下是由下列一般式（I）表示的噻唑烷-4-酮衍生物及其酸加成盐：##STR1## 其中，R.sup.1和R.sup.2相同或不同，分别表示（i）由一般式--A--R.sup.4表示的残基，其中，A表示单键，C.sub.1-C.sub.8烷基，C.sub.2-C.sub.8烯基或C.sub.2-C.sub.8炔基，而R.sup.4表示氢，C.sub.1-C.sub.12烷基，C.sub.2-C.sub.8烯基，C.sub.3-C.sub.8环烷基或C.sub.1-C.sub.6卤代烷基；或（ii）由下列一般式表示的残基：##STR2## 其中，B表示单键或C.sub.1-C.sub.6烷基，R.sup.5表示氢，C.sub.1-C.sub.6烷基，C.sub.2-C.sub.8烯基，C.sub.3-C.sub.8环烷基，取代硅烷基或取代或未取代芳基，n和n'分别表示2到4的整数，m表示1到3的整数，而m'表示0到2的整数；R.sup.3表示氢，C.sub.1-C.sub.2烷基，烯丙基，2-丙炔基或由下列一般式表示的残基--F--R.sup.9，其中，F表示C.sub.2-C.sub.6烷基，而R.sup.9表示含氮杂环芳基残基或由下列一般式表示的氨基：##STR3## （其中，R.sup.10表示氢，C.sub.2-C.sub.4烷基或C.sub.1-C.sub.4酰基，而R.sup.11表示氢或C.sub.1-C.sub.4烷基，或R.sup.10与R.sup.11组合表示可选地含有其他杂原子的5-至7-成员环氨基。）这些化合物具有选择性的PAF-拮抗活性，非常有用作为预防和治疗PAF引起的疾病，例如各种炎症，过敏性疾病，循环系统疾病和胃肠疾病的药物。
• Tanabe, Yoo; Yamamoto, Hitomi; Murakami, Masanari, Journal of the Chemical Society. Perkin transactions I, 1995, # 7, p. 935 - 948
  作者：Tanabe, Yoo、Yamamoto, Hitomi、Murakami, Masanari、Yanagi, Kazunori、Kubota, Yoshino、et al.

  DOI：——

  日期：——