dimethyl 3-acetoxyphthalate | 2073-27-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dimethyl 3-acetoxyphthalate
• 英文别名: Dimethyl-3-acetoxy-phthalat；3-acetoxy-phthalic acid dimethyl ester；3-Acetoxy-phthalsaeure-dimethylester；Dimethyl 3-acetyloxybenzene-1,2-dicarboxylate
• CAS: 2073-27-0
• 化学式: C₁₂H₁₂O₆
• 分子量: 252.224
• InChiKey: NRXMPLQBORKHRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-hydroxy-phthalic acid-1-methyl ester 在 sodium hydroxide 、 乙醚 作用下， 生成 dimethyl 3-acetoxyphthalate
  参考文献：
  名称：

  The Methyl Esters of 3-Hydroxyphthalic Acid. Selective Reduction of Monomethyl Phthalates with Lithium Aluminum Hydride

  摘要：

  DOI：

  10.1021/ja01624a042

文献信息

• [EN] DIELS- ALDER RING-OPENING PROCESS<br/>[FR] PROCÉDÉ D'OUVERTURE DE CYCLE DE DIELS-ALDER
  申请人：TNO

  公开号：WO2019212338A1

  公开（公告）日：2019-11-07

  The invention is directed to a process for the ring-opening of a cycloadduct of formula I obtainable from a reaction of a furanic compound and a diene, said process comprising contacting the cycloadduct with an acidic mixture comprising sulfuric acid and an activating agent to obtain a ring-opened product. The present invention is particularly directed a continuous process.

  该发明涉及一种用于打开式环化合物的环开放过程，所述环化合物的结构式为I，可从呋喃类化合物和二烯烃的反应中获得，所述过程包括将环化合物与含有硫酸和活化剂的酸性混合物接触，以获得一个环开放产物。本发明特别涉及一种连续过程。
• 5,12-dihydroxy-1,2,3,4,6,11-hexahydro-2,6,11-trioxonaphthacenes and their synthesis
  申请人：THE UNIVERSITY OF KANSAS

  公开号：EP0007403A1

  公开（公告）日：1980-02-06

  A process for synthesizing the 7-substituted or unsubstituted 5,12-dihydroxy- 1,2,3,4,6,11-hexahydro- 2,6,11- trioxonaphthacene precursors for doxorubicin and related compounds from butadiene and p-benzoquinone and intermediates useful in the synthesis.

  一种用丁二烯和对苯醌合成多柔比星及相关化合物的 7-取代或未取代的 5,12-二羟基-1,2,3,4,6,11-六氢-2,6,11-三氧杂萘前体的工艺，以及合成中有用的中间体。
• Intermediate products occurring in anthracycline synthesis
  申请人：THE UNIVERSITY OF KANSAS

  公开号：EP0043435A1

  公开（公告）日：1982-01-13

  Various valuable intermediate products occurring in the synthesis and being useful in synthesizing doxorubicin and related compounds.

  合成过程中出现的各种有价值的中间产物，可用于合成多柔比星和相关化合物。
• DIELS- ALDER RING-OPENING PROCESS
  申请人：NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK TNO

  公开号：EP3788030A1

  公开（公告）日：2021-03-10
• DIELS-ALDER RING-OPENING PROCESS
  申请人：Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO

  公开号：US20210115005A1

  公开（公告）日：2021-04-22

  The invention is directed to a process for the ring-opening of a cycloadduct obtainable from a reaction of a furanic compound and a diene, said process comprising contacting the cycloadduct with an acidic mixture comprising sulfuric acid and an activating agent to obtain a ring-opened product. The present invention is particularly directed a continuous process.