[(8S,13S,14S,17S)-3-acetyloxy-13-methyl-1,2,6,7,8,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] acetate | 24277-48-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: [(8S,13S,14S,17S)-3-acetyloxy-13-methyl-1,2,6,7,8,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] acetate
• CAS: 24277-48-3
• 化学式: C₂₂H₂₈O₄
• 分子量: 356.462
• InChiKey: CEKKLGKZIFLIDV-MLNNCEHLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.61
• 重原子数：
  26.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  [(8S,13S,14S,17S)-3-acetyloxy-13-methyl-1,2,6,7,8,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] acetate 在 碳酸氢钠 作用下， 以 甲醇 为溶剂， 生成 Acetic acid (8S,13S,14S,17S)-13-methyl-3-oxo-2,3,4,6,7,8,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester
  参考文献：
  名称：

  New compounds and improved procedures

  摘要：

  DOI：

  10.1016/0039-128x(69)90035-x
• 作为产物：
  描述：

  17β-羟基雌甾-4,9-二烯-3-酮 、 乙酰氯 在 吡啶 、 乙酸酐 作用下， 生成 [(8S,13S,14S,17S)-3-acetyloxy-13-methyl-1,2,6,7,8,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] acetate
  参考文献：
  名称：

  New compounds and improved procedures

  摘要：

  DOI：

  10.1016/0039-128x(69)90035-x

文献信息

• PROCESS FOR THE PREPARATION OF TRENBOLONE ACETATE HAVING A DEFINITE PARTICLE SIZE DISTRIBUTION AND A IRREGULAR HEXAGON PLATES CRYSTAL HABIT
  申请人：F.I.S.- Fabbrica Italiana Sintetici S.p.A.

  公开号：EP4001288A1

  公开（公告）日：2022-05-25

  Object of the present invention is an improved process for the preparation of Trenbolone Acetate of formula (I): having irregular hexagon plates crystal habit, by means of crystallization of Trenbolone Acetate of formula (I) with a C2-C5 alkyl alcohol or mixture thereof.

  本发明的目的是改进制备式（I）醋酸群勃龙的工艺： 本发明的目的是通过将式(I)的醋酸群勃龙酯与 C2-C5 烷醇或其混合物结晶，制备具有不规则六角板晶型的醋酸群勃龙酯的改进工艺。
• PROCESS FOR THE PREPARATION OF TRENBOLONE ACETATE HAVING A DEFINITE PARTICLE SIZE DISTRIBUTION
  申请人：F.I.S.- Fabbrica Italiana Sintetici S.p.A.

  公开号：EP4000688A1

  公开（公告）日：2022-05-25

  Object of the present invention is related to a process for the preparation of Trenbolone Acetate of formula (I): having a median value (D50) of the particle size distribution comprised in the range from 50 µm to 80 µm, or from 60 µm to 90 µm, or from 90 µm to 250 µm, by means of addition of a seed having a median value (D50) of the particle size distribution comprised respectively in the range from 8 µm to 15 µm, or from 15 µm to 20 µm, or from 20 µm to 90 µm, to a solution of Trenbolone Acetate in a solvent.

  本发明的目的是关于制备式 (I) 的醋酸群勃龙的工艺： 将粒度分布中值（D50）分别为 8 微米至 15 微米，或 15 微米至 20 微米，或 20 微米至 90 微米的种子加入到醋酸群勃龙在溶剂中的溶液中，该种子的粒度分布中值（D50）范围为 50 微米至 80 微米，或 60 微米至 90 微米，或 90 微米至 250 微米。
• IMPROVED PROCESS FOR THE PREPARATION OF TRENBOLONE AND/OR TRENBOLONE ACETATE
  申请人：F.I.S.- Fabbrica Italiana Sintetici S.p.A.

  公开号：EP4001289A1

  公开（公告）日：2022-05-25

  Object of the present invention is an improved process for the preparation of Trenbolone (I-b) and/or Trenbolone Acetate (I-a) comprising the reaction of the compound of formula (II): wherein R is H or Ac; with an oxidant agent in presence of an acid.

  本发明的目的是改进制备群勃龙（I-b）和/或醋酸群勃龙（I-a）的工艺，包括式（II）化合物的反应： 其中 R 为 H 或 Ac；在酸存在下与氧化剂反应。
• [EN] PROCESS FOR THE PREPARATION OF TRENBOLONE ACETATE HAVING A DEFINITE PARTICLE SIZE DISTRIBUTION AND A IRREGULAR HEXAGON PLATES CRYSTAL HABIT<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION D'ACÉTATE DE TRENBOLONE AYANT UNE DISTRIBUTION DE TAILLE DE PARTICULE DÉFINIE ET UN HABITUS CRISTALLIN EN PLAQUE HEXAGONALE IRRÉGULIÈRE
  申请人：[en]F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.

  公开号：WO2022106566A1

  公开（公告）日：2022-05-27

  Object of the present invention is an improved process for the preparation of Trenbolone Acetate of formula (I) having irregular hexagon plates crystal habit and/or a median value (D50) of the particle size distribution comprised in the range from 50 μm to 80 μm, or from 60 μm to 90 μm, or from 90 μm to 250 μm, by means of a crystallization wherein an addition of a seed having a median value (D50) of the particle size distribution comprised respectively in the range from 8 μm to 15 μm, or from 15 μm to 20 μm, or from 20 μm to 90 μm, to a solution of Trenbolone Acetate in a solvent, wherein the solvent is a C2-C5 alkyl alcohol or mixture thereof.
• [EN] IMPROVED PROCESS FOR THE PREPARATION OF TRENBOLONE AND/OR TRENBOLONE ACETATE<br/>[FR] PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION D'ACÉTATE DE TRENBOLONE ET/OU DE TRENBOLONE
  申请人：[en]F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.

  公开号：WO2022106574A1

  公开（公告）日：2022-05-27

  Object of the present invention is an improved process for the preparation of Trenbolone (I-b) and/or Trenbolone Acetate (I-a) comprising the reaction of the compound of formula (II): wherein R is H or Ac; with an oxidant agent in presence of an acid.