2,3-dihydro-benzo[f]phthalazine-1,4-dione | 25815-95-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2,3-dihydro-benzo[f]phthalazine-1,4-dione
• 英文别名: 2,3-Dihydro-benzo[f]phthalazin-1,4-dion；2,3-dihydrobenzo[f]phthalazine-1,4-dione
• CAS: 25815-95-6
• 化学式: C₁₂H₈N₂O₂
• 分子量: 212.208
• InChiKey: TVEBBLUMHPXZCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3-dihydro-benzo[f]phthalazine-1,4-dione 在 lead(IV) acetate 、 蒽 作用下， 以 二氯甲烷 为溶剂， 25.0~500.0 ℃ 、1.33 Pa 条件下， 反应 5.5h， 生成 cyclobutanaphthalene-1,2-dione
  参考文献：
  名称：

  Gould, Ken J.; Hacker, Nigel P.; McOmie, John F. W., Journal of the Chemical Society. Perkin transactions I, 1980, p. 1834 - 1840

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2-萘二酸酐 在 一水合肼 作用下， 以 溶剂黄146 为溶剂， 反应 0.5h， 生成 2,3-dihydro-benzo[f]phthalazine-1,4-dione
  参考文献：
  名称：

  Gould, Ken J.; Hacker, Nigel P.; McOmie, John F. W., Journal of the Chemical Society. Perkin transactions I, 1980, p. 1834 - 1840

  摘要：

  DOI：

文献信息

• Naphthofuranone Derivatives as Specific Inhibitors of Thymidylate Synthases
  申请人：Venturelli Alberto

  公开号：US20100048692A1

  公开（公告）日：2010-02-25

  Synthetic compounds of 1,2-naphthalein moelcules (I) having specific inhibitory properties of the enzymatic activity of thymidylate synthases of bacterial species, their preparation, their pharmaceutical composition and use in the treatment and prophylaxis of infectious pathologies are disclosed.

  本发明揭示了具有特定抑制细菌种类嘧啶核苷酸合成酶酶活性的1,2-萘醌分子(I)的合成化合物，其制备方法，药用组合物以及在治疗和预防感染性病理中的应用。
• Kit and method for the labelling of biomolecules
  申请人：Cyanagen Srl

  公开号：EP2314597A1

  公开（公告）日：2011-04-27

  The present invention relates to a kit for the labelling of biomolecules bearing reactive amino or hydroxyl groups. The kit consists of a Reagent A and a Reagent B, individually packaged, comprising: a mixture of a carboxylated labelling compound and a tertiary amine (Reagent A); and a coupling reagent (Reagent B). Upon contacting Reagent A with Reagent B, the carboxylated labelling compound is activated in-situ by the coupling reagent (a guanidinium, or uronium salt) in the presence of the tertiary amine. The active form of the carboxylated labelling compound is reacted with a biomolecules bearing reactive amino or hydroxyl groups, with formation of a stable covalent bond between the carboxylated labelling compound and the biomolecule.

  本发明涉及一种对带有活性氨基或羟基的生物大分子进行标记的试剂盒。该试剂盒包括单独包装的试剂 A 和试剂 B，其中试剂 A 是羧基化标记化合物和叔胺的混合物；试剂 B 是偶联试剂。试剂 A 与试剂 B 接触后，羧化标记化合物在叔胺存在下被偶联试剂（胍盐或脲盐）原位活化。羧化标记化合物的活性形式与带有活性氨基或羟基的生物大分子反应，在羧化标记化合物和生物大分子之间形成稳定的共价键。
• 177. Chemiluminescent organic compounds. Part VII. Substituted phthalaz-1 : 4-diones. Effect of substituents on the luminescent power
  作者：H. D. K. Drew、R. F. Garwood

  DOI：10.1039/jr9390000836

  日期：——
• GOULD K. J.; HACKER N. P.; MCOMIE J. F. W.; PERRY D. H., J. CHEM. SOC. PERKIN TRANS., PART 1, 1980, NO 8, 1834-1840
  作者：GOULD K. J.、 HACKER N. P.、 MCOMIE J. F. W.、 PERRY D. H.

  DOI：——

  日期：——
• KIT AND METHOD FOR THE LABELLING OF BIOMOLECULES
  申请人：DELLA CIANA Leopoldo

  公开号：US20110092676A1

  公开（公告）日：2011-04-21

  The present invention relates to a kit for the labelling of biomolecules bearing reactive amino or hydroxyl groups. The kit consists of a Reagent A and a Reagent B, individually packaged, comprising: a mixture of a carboxylated labelling compound and a tertiary amine (Reagent A); and a coupling reagent (Reagent B). Upon contacting Reagent A with Reagent B, the carboxylated labelling compound is activated in-situ by the coupling reagent (a guanidinium, or uranium salt) in the presence of the tertiary amine. The active form of the carboxylated labelling compound is reacted with a biomolecules bearing reactive amino or hydroxyl groups, with formation of a stable covalent bond between the carboxylated labelling compound and the biomolecule.