4-nitrobenzoyl glycine amide | 5410-49-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-nitrobenzoyl glycine amide
• 英文别名: N-(4-nitro-benzoyl)-glycine amide；N-(4-Nitro-benzoyl)-glycin-amid；n-(2-Amino-2-oxoethyl)-4-nitrobenzamide
• CAS: 5410-49-1
• 化学式: C₉H₉N₃O₄
• mdl: MFCD12973344
• 分子量: 223.188
• InChiKey: KAYJNRVUJFLXMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-nitrobenzoyl glycine amide 在 乙醇 、 钯 作用下， 生成 N-(4-amino-benzoyl)-glycine amide
  参考文献：
  名称：

  Plasma atrial natriuretic peptide levels in essential hypertension after treatment with verapamil

  摘要：

  The aim of this study was to evaluate the long term effects of the selective Ca2+ blocker verapamil on atrial natriuretic peptide (ANP) levels in patients with moderate essential hypertension. The drug was given orally in a daily dose of 300 mg for 30 days. At the end of this clinical trial, plasma ANP levels increased by 16.14% despite the drop in blood pressure while left atrial and ventricular diameters remained unchanged. These findings indicate that the increase of ANP plasma levels is not the result of a mechanical load on the left cardiac chambers but the result of a pharmacological action. These observations also indicate that verapamil exerts part of its antihypertensive action by increasing ANP plasma levels.

  DOI：

  10.1007/bf03190404
• 作为产物：
  描述：

  N-(cyanomethyl)-4-nitrobenzamide 生成 4-nitrobenzoyl glycine amide
  参考文献：
  名称：

  Brachwitz,H., Journal fur praktische Chemie (Leipzig 1954), 1972, vol. 314, p. 447 - 454

  摘要：

  DOI：

文献信息

• Substituent Effect on Acidity of Substituted 2-(4-Nitrobenzoylamino)alkanamides in Methanol-Dimethyl Sulfoxide Mixtures
  作者：Petr Mitaš、Miloš Sedlák、Jaromír Kaválek

  DOI：10.1135/cccc19980085

  日期：——

  The dissociation constants of substituted 2-(4-nitrobenzoylamino)alkanamides, N-[2-(4-nitrobenzoylamino)alkanoyl]pyrrolidines, and N-alkyl-4-nitrobenzamides have been measured spectrophotometrically in 60 and 80% v/v DMSO. The pK_A values of these N-acids are discussed from the point of view of substituents at the acetamide α-carbon atom.

  已发送中文翻译结果。如果您有任何其他问题或需要进一步帮助，请随时告诉我。谢谢！
• Stabilizing and Destabilizing Effects of Phenylalanine → F₅-Phenylalanine Mutations on the Folding of a Small Protein
  作者：Matthew G. Woll、Erik B. Hadley、Sandro Mecozzi、Samuel H. Gellman

  DOI：10.1021/ja0634573

  日期：2006.12.1

  --> F5-Phe) mutants for the 35-residue chicken villin headpiece subdomain (c-VHP), the hydrophobic core of which features a cluster of three Phe side chains (residues 6, 10, and 17). Phe --> F5-Phe mutations are interesting because aryl-perfluoroaryl interactions of optimal geometry are intrinsically more favorable than aryl-aryl interactions and because perfluoroaryl units are more hydrophobic than are

  我们报告了苯丙氨酸到五氟苯丙氨酸 (Phe --> F5-Phe) 突变体的 35 个残留鸡绒毛头饰子域 (c-VHP) 的系统评估，其疏水核心具有三个 Phe 侧链的簇（残基 6、10 和 17)。Phe --> F5-Phe 突变很有趣，因为最佳几何形状的芳基-全氟芳基相互作用本质上比芳基-芳基相互作用更有利，并且因为全氟芳基单元比类似的芳基单元更疏水。一种突变体 Phe-10 --> F5-Phe 提供了相对于天然序列增强的三级结构稳定性。分析的其他六个突变体导致稳定性下降。
• p-Arsenosobenzoylurea and Related Compounds¹
  作者：H. G. Steinman、G. O. Doak、Harry Eagle

  DOI：10.1021/ja01230a009

  日期：1944.2
• Nogami et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1951, vol. 71, p. 1494
  作者：Nogami et al.

  DOI：——

  日期：——
• New Charge-Bearing Amino Acid Residues That Promote β-Sheet Secondary Structure
  作者：Stacy J. Maynard、Aaron M. Almeida、Yasuharu Yoshimi、Samuel H. Gellman

  DOI：10.1021/ja510265e

  日期：2014.11.26

  Proteinogenic amino acid residues that promote beta-sheet secondary structure are hydrophobic (e.g., Ile or Val) or only moderately polar (e.g., Thr). The design of peptides intended to display beta-sheet secondary structure in water typically requires one set of residues to ensure conformational stability and an orthogonal set, with charged side chains, to ensure aqueous solubility and discourage self-association. Here we describe new amino acids that manifest substantial beta-sheet propensity, by virtue of beta-branching, and also bear an ionizable group in the side chain.