5-methyl-2-(3-phenylpropanamido)benzamide | 1448462-34-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-methyl-2-(3-phenylpropanamido)benzamide
• 英文别名: 5-Methyl-2-(3-phenylpropanoylamino)benzamide；5-methyl-2-(3-phenylpropanoylamino)benzamide
• CAS: 1448462-34-7
• 化学式: C₁₇H₁₈N₂O₂
• 分子量: 282.342
• InChiKey: RHBJSXACCJTPRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-甲基-2-硝基苯甲酰胺 在 吡啶 、 盐酸 、 tin(ll) chloride 作用下， 反应 49.5h， 生成 5-methyl-2-(3-phenylpropanamido)benzamide
  参考文献：
  名称：

  2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: Synthesis, antiproliferative activity, and mechanism of action

  摘要：

  Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells). (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.04.068

文献信息

• 2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: Synthesis, antiproliferative activity, and mechanism of action
  作者：Demetrio Raffa、Benedetta Maggio、Maria Valeria Raimondi、Maria Grazia Cusimano、Giandomenico Amico、Anna Carollo、Pier Giulio Conaldi、Ruoli Bai、Ernest Hamel、Giuseppe Daidone

  DOI：10.1016/j.ejmech.2013.04.068

  日期：2013.7

  Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells). (C) 2013 Elsevier Masson SAS. All rights reserved.