1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine hydrochloride | 1125474-24-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine hydrochloride
• 英文别名: [4-(Oxan-4-yloxy)phenyl]-(4-propan-2-ylpiperazin-1-yl)methanone;hydrochloride
• CAS: 1125474-24-9
• 化学式: C₁₉H₂₈N₂O₃*ClH
• 分子量: 368.904
• InChiKey: QHIGDHXXUBGZEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.83
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (4-isopropylpiperazin-1-yl)(4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)methanone 在 盐酸 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 生成 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine hydrochloride
  参考文献：
  名称：

  [EN] PIPERAZINE DERIVATIVE HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR
  [FR] DÉRIVÉ DE PIPÉRAZINE PRÉSENTANT UNE AFFINITÉ POUR LE RÉCEPTEUR H3 DE L'HISTAMINE

  摘要：

  本发明涉及1-(1-甲基乙基)-4-{[4-(四氢-2H-吡喃-4-氧基)苯基]羰基}哌嗪（分子式）或其药学上可接受的盐，特别是其盐酸盐及其盐酸盐的结晶形式；制备该化合物或其盐的方法；含有它的组合物；以及其在治疗或预防神经系统或精神疾病，如认知障碍、疲劳或睡眠障碍等方面的用途，例如在哺乳动物中，如人类。该化合物或其盐对组织胺H3受体具有亲和力，并且是组织胺H3受体的拮抗剂和/或逆向激动剂。

  公开号：

  WO2009030716A1

文献信息

• Piperazine Derivative Having Affinity for the Histamine H3 Receptor
  申请人：Best Desmond John

  公开号：US20100204242A1

  公开（公告）日：2010-08-12

  The present invention relates to 1-(1-methylethyl)-4-[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine or a pharmaceutically acceptable salt thereof, in particular the hydrochloride salt thereof and crystalline forms of the hydrochloride salt; to processes for the preparation of the compound or its salt; to compositions containing it; and to its use in the treatment or prophylaxis of neurological or psychiatric diseases, such as cognitive impairment, fatigue or a sleep disorder, for example in a mammal such as a human. The compound or a salt thereof has affinity for and is an antagonist and/or inverse agonist of the histamine H3 receptor.

  本发明涉及1-(1-甲基乙基)-4-[4-(四氢-2H-吡喃-4-氧基)苯基]甲酰基}哌嗪或其药学上可接受的盐，特别是其盐酸盐及其盐酸盐的晶体形式；制备该化合物或其盐的过程；含有该化合物的组合物；以及在哺乳动物，例如人类中治疗或预防神经系统或精神疾病，如认知障碍、疲劳或睡眠障碍等方面的用途。该化合物或其盐具有亲和力并且是组胺H3受体的拮抗剂和/或反向激动剂。
• PIPERAZINE DERIVATIVE HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR
  申请人：BEST Desmond John

  公开号：US20090170869A1

  公开（公告）日：2009-07-02

  The present invention relates to 1-(1-methylethyl)-4-[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine or a pharmaceutically acceptable salt thereof, in particular the hydrochloride salt thereof and crystalline forms of the hydrochloride salt; to processes for the preparation of the compound or its salt; to compositions containing it; and to its use in the treatment or prophylaxis of neurological or psychiatric diseases, such as cognitive impairment, fatigue or a sleep disorder, for example in a mammal such as a human. The compound or a salt thereof has affinity for and is an antagonist and/or inverse agonist of the histamine H3 receptor.

  本发明涉及1-(1-甲基乙基)-4-[4-(四氢-2H-吡喃-4-氧基)苯基]羰基}哌嗪或其药学上可接受的盐，特别是其盐酸盐和盐酸盐的结晶形式；制备该化合物或其盐的方法；含有该化合物的组合物；以及其在治疗或预防神经系统或精神系统疾病中的应用，例如认知障碍、疲劳或睡眠障碍，例如在哺乳动物如人类中。该化合物或其盐具有亲和力，并且是组胺H3受体的拮抗剂和/或反向激动剂。
• US8288389B2
  申请人：——

  公开号：US8288389B2

  公开（公告）日：2012-10-16
• [EN] PIPERAZINE DERIVATIVE HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR<br/>[FR] DÉRIVÉ DE PIPÉRAZINE PRÉSENTANT UNE AFFINITÉ POUR LE RÉCEPTEUR H3 DE L'HISTAMINE
  申请人：GLAXO GROUP LTD

  公开号：WO2009030716A1

  公开（公告）日：2009-03-12

  The present invention relates to 1-(1-methylethyl)-4-[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine (Formula) or a pharmaceutically acceptable salt thereof, in particular the hydrochloride salt thereof and crystalline forms of the hydrochloride salt; to processes for the preparation of the compound or its salt; to compositions containing it; and to its use in the treatment or prophylaxis of neurological or psychiatric diseases, such as cognitive impairment, fatigue or a sleep disorder, for example in a mammal such as a human. The compound or a salt thereof has affinity for and is an antagonist and/or inverse agonist of the histamine H3 receptor.

  本发明涉及1-(1-甲基乙基)-4-[4-(四氢-2H-吡喃-4-氧基)苯基]羰基}哌嗪（分子式）或其药学上可接受的盐，特别是其盐酸盐及其盐酸盐的结晶形式；制备该化合物或其盐的方法；含有它的组合物；以及其在治疗或预防神经系统或精神疾病，如认知障碍、疲劳或睡眠障碍等方面的用途，例如在哺乳动物中，如人类。该化合物或其盐对组织胺H3受体具有亲和力，并且是组织胺H3受体的拮抗剂和/或逆向激动剂。