4-乙酰氨基-2-氯吡啶 | 13602-82-9

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 4-乙酰氨基-2-氯吡啶
• 中文别名: N-2-氯嘧啶-4-乙酰胺；N-(2-氯吡啶-4-基)乙酰胺
• 英文名称: N-(2-chloro-pyridin-4-yl)-acetamide
• 英文别名: N-(2-chloropyridin-4-yl)-acetamide；N-(2-chloropyridin-4-yl)acetamide
• CAS: 13602-82-9
• 化学式: C₇H₇ClN₂O
• mdl: MFCD00234294
• 分子量: 170.598
• InChiKey: DFUPWNHYRNYOHQ-UHFFFAOYSA-N

物化性质

• 沸点：
  369.9±27.0 °C(Predicted)
• 密度：
  1.336±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 4-Acetamido-2-chloropyridine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 4-Acetamido-2-chloropyridine
CAS number: 13602-82-9

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C7H7ClN2O
Molecular weight: 170.6

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-乙酰氨基-2-氯吡啶 生成 2-氯-4-氨基吡啶
  参考文献：
  名称：

  YAMAUTI, KOSUKEH;NAKAO, KEHNDZI;NISIMURA, SUKEHMIO;TAMAOKI, KEHNTARO

  摘要：

  DOI：
• 作为产物：
  描述：

  (NE)-N-[1-(2-chloropyridin-4-yl)ethylidene]hydroxylamine 生成 4-乙酰氨基-2-氯吡啶
  参考文献：
  名称：

  YAMAUTI, KOSUKEH;NAKAO, KEHNDZI;NISIMURA, SUKEHMIO;TAMAOKI, KEHNTARO

  摘要：

  DOI：

文献信息

• [EN] INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION<br/>[FR] INHIBITEURS DE LA REPLICATION DU VIRUS DE L'IMMUNODEFICIENCE HUMAINE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2010130034A1

  公开（公告）日：2010-11-18

  Compounds of formula I wherein a, R1, R2, R3, R4, R5 and R6 are defined herein, are useful as inhibitors of HIV replication.

  式I中的化合物，其中a、R1、R2、R3、R4、R5和R6如本文所定义，可用作HIV复制抑制剂。
• METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS
  申请人：Duke University

  公开号：US20140371194A1

  公开（公告）日：2014-12-18

  This invention relates generally to the discovery of a method of inhibiting, preventing or treating bacterial infections. The invention also relates to a method of inhibiting bacterial capsule biogenesis.

  这项发明通常涉及发现一种抑制、预防或治疗细菌感染的方法。该发明还涉及一种抑制细菌胶囊生物合成的方法。
• Piperazinyl-pyridine derivatives
  申请人：Nettekoven Heinrich Matthias

  公开号：US20060135528A1

  公开（公告）日：2006-06-22

  The present invention relates to compounds of formula I wherein R 1 , R 2 , X, Y, Z and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical composition comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

  本发明涉及式I的化合物，其中R1、R2、X、Y、Z和m如描述和权利要求中所定义，以及其药学上可接受的盐，以及包含这些化合物的制药组合物以及其制备方法。这些化合物对于与H3受体调节相关的疾病的治疗和/或预防是有用的。
• PIPERAZINYL-PYRIDINE DERIVATIVES
  申请人：Nettekoven Matthias Heinrich

  公开号：US20090042903A1

  公开（公告）日：2009-02-12

  The present invention relates to compounds of formula I wherein R 1 , R 2 , X, Y, Z and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical composition comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

  本发明涉及以下式子的化合物：其中R1、R2、X、Y、Z和m如所述和索要的定义，以及其药学上可接受的盐，以及包含这些化合物的制药组合物和它们的制备方法。这些化合物对于治疗和/或预防与H3受体调节相关的疾病是有用的。
• WO2006/63718
  申请人：——

  公开号：——

  公开（公告）日：——